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Protein Overview: GPH1

General Information:
Name(s) found: GPH1 / YPR160W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 902 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: glycogen catabolic process [IMPLink to PubMed article]
    Molecular Function: glycogen phosphorylase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPASTSTTN DMITEEPTSP HQIPRLTRRL TGFLPQEIKS IDTMIPLKSR ALWNKHQVKK  60
   61 FNKAEDFQDR FIDHVETTLA RSLYNCDDMA AYEAASMSIR DNLVIDWNKT QQKFTTRDPK 120
  121 RVYYLSLEFL MGRALDNALI NMKIEDPEDP AASKGKPREM IKGALDDLGF KLEDVLDQEP 180
  181 DAGLGNGGLG RLAACFVDSM ATEGIPAWGY GLRYEYGIFA QKIIDGYQVE TPDYWLNSGN 240
  241 PWEIERNEVQ IPVTFYGYVD RPEGGKTTLS ASQWIGGERV LAVAYDFPVP GFKTSNVNNL 300
  301 RLWQARPTTE FDFAKFNNGD YKNSVAQQQR AESITAVLYP NDNFAQGKEL RLKQQYFWCA 360
  361 ASLHDILRRF KKSKRPWTEF PDQVAIQLND THPTLAIVEL QRVLVDLEKL DWHEAWDIVT 420
  421 KTFAYTNHTV MQEALEKWPV GLFGHLLPRH LEIIYDINWF FLQDVAKKFP KDVDLLSRIS 480
  481 IIEENSPERQ IRMAFLAIVG SHKVNGVAEL HSELIKTTIF KDFVKFYGPS KFVNVTNGIT 540
  541 PRRWLKQANP SLAKLISETL NDPTEEYLLD MAKLTQLGKY VEDKEFLKKW NQVKLNNKIR 600
  601 LVDLIKKEND GVDIINREYL DDTLFDMQVK RIHEYKRQQL NVFGIIYRYL AMKNMLKNGA 660
  661 SIEEVAKKYP RKVSIFGGKS APGYYMAKLI IKLINCVADI VNNDESIEHL LKVVFVADYN 720
  721 VSKAEIIIPA SDLSEHISTA GTEASGTSNM KFVMNGGLII GTVDGANVEI TREIGEDNVF 780
  781 LFGNLSENVE ELRYNHQYHP QDLPSSLDSV LSYIESGQFS PENPNEFKPL VDSIKYHGDY 840
  841 YLVSDDFESY LATHELVDQE FHNQRSEWLK KSVLSVANVG FFSSDRCIEE YSDTIWNVEP 900
  901 VT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAC3 ABP1 ACO1 ACS2 ADE3 ADE5,7 ADE6 ADK1 ADO1 AIM41 ALA1 APE2 ARA1 ATP3 ATP4 AVO1 AXL1 BAT1 BCY1 BUD14 CAR2 CCT5 CDC10 CFT1 CIC1 CLU1 COP1 COR1 CPR6 CRZ1 CYR1 CYS3 CYS4 DBF2 DBF20 DCP1 DCP2 DED81 DHH1 DNM1 DPB2 DPS1 DUN1 EDC3 EDE1 EGD2 ENP1 ERB1 ERG10 ERG20 FAA1 FIN1 FIP1 FPR3 FPR4 FUN12 GAL7 GAS1 GCN3 GCY1 GDB1 GIP2 GLC7 GLC8 GND1 GPH1 GRS1 GSY2 HER1 HHF1, HHF2 HOM2 HOR2 HRK1 HRR25 HSP104 HXT7 HYP2 IDH1 IDH2 ILS1 ILV2 IMD3 IPP1 JJJ1 KEL1 KGD1 KRS1 LOC1 LSP1 LTV1 MAM33 MDH1 MDH3 MDS3 MET16 MGE1 MHP1 MKK2 MKT1 MOB1 MRE11 NAN1 NAT1 NOG2 NPA3 NSA1 NUG1 OLA1 OYE2 PAB1 PDX1 PEX19 PFK1 PFK2 PGM2 PHO85 PIL1 PIN4 PMI40 PRP11 PRP6 PSK1 PSK2 PST2 PTC4 PUF3 RAD30 RAD50 REG1 REX2 RIO2 RNQ1 ROD1 RPB10 RPC19 RPM2 RPN12 RPN5 RPT3 RPT5 RRP17 RVB1 SAC6 SAP185 SAP190 SAS10 SCD5 SCP160 SCS2 SDS22 SEC2 SEC23 SEC27 SEN1 SES1 SFB3 SGM1 SHM2 SIP1 SIS1 SIT4 SLX1 SML1 SNF4 SOD1 SPB1 SRP54 SSK2 SSZ1 STI1 SUI2 SUI3 TEM1 TFC7 TFP1 THI22 THR4 TIF4631 TMA19 TPK1 TPK3 TPS1 TPS2 TRR1 TSR1 UBA1 UBP15 UTP10 UTP13 UTP9 VMA4 VMA8 XRS2 YBR225W YDL124W YER077C YER138C YGR250C YGR266W YHR033W YHR214W-A YKR051W YKU80 YLR271W YPR003C YPT7 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD51 GPH1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GPH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219]
    [232..547]
    [882..902]    		 PSI-BLAST 11000.0 Glycogen phosphorylase
    2 View Details [220..231]
    [548..881]    		 PSI-BLAST 11000.0 Glycogen phosphorylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glycogen phosphorylase activity
    		•  5.43556332287206 bayes_pls_golite062009
  • phosphorylase activity
    		•  4.4363209226962 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  3.70184884300914 bayes_pls_golite062009
  • catalytic activity
    		•  2.65148466065976 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.62403914335522 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.13085705769565 bayes_pls_golite062009
  • glucosyltransferase activity
    		•  2.11024512158394 bayes_pls_golite062009
  • UDP-glucosyltransferase activity
    		•  1.84595685206241 bayes_pls_golite062009
  • transferase activity
    		•  1.47703555225615 bayes_pls_golite062009
  • binding
    		•  1.22341386111754 bayes_pls_golite062009
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
    		•  0.849686864309466 bayes_pls_golite062009
  • UDP-N-acetylglucosamine 2-epimerase activity
    		•  0.690032302126686 bayes_pls_golite062009
  • sugar binding
    		•  0.68155433315706 bayes_pls_golite062009
  • hydrolase activity
    		•  0.507333921449805 bayes_pls_golite062009
  • acetylglucosaminyltransferase activity
    		•  0.354187614795831 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.253888301381021 bayes_pls_golite062009
  • drug binding
    		•  0.102804615007901 bayes_pls_golite062009
  • protein binding
    		•  0.0755094482594821 bayes_pls_golite062009
  • carboxylic acid binding
    		•  0.00262987576299967 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  4.32270241054966E-4 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle