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Protein Overview: MRE11

General Information:
Name(s) found: MRE11 / YMR224C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 692 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Mre11 complex [IPILink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    meiotic DNA double-strand break processing [TASLink to PubMed article]
    double-strand break repair via break-induced replication [IGILink to PubMed article][IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IMPLink to PubMed article]
    meiotic DNA double-strand break formation [TASLink to PubMed article]
    Molecular Function: adenylate kinase activity [IDALink to PubMed article]
    3'-5' exonuclease activity [IDALink to PubMed article]
    protein binding [IPILink to PubMed article]
    telomeric DNA binding [IDALink to PubMed articleLink to PubMed article]
    endonuclease activity [IDALink to PubMed article]
    endodeoxyribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYPDPDTIR ILITTDNHVG YNENDPITGD DSWKTFHEVM MLAKNNNVDM VVQSGDLFHV  60
   61 NKPSKKSLYQ VLKTLRLCCM GDKPCELELL SDPSQVFHYD EFTNVNYEDP NFNISIPVFG 120
  121 ISGNHDDASG DSLLCPMDIL HATGLINHFG KVIESDKIKV VPLLFQKGST KLALYGLAAV 180
  181 RDERLFRTFK DGGVTFEVPT MREGEWFNLM CVHQNHTGHT NTAFLPEQFL PDFLDMVIWG 240
  241 HEHECIPNLV HNPIKNFDVL QPGSSVATSL CEAEAQPKYV FILDIKYGEA PKMTPIPLET 300
  301 IRTFKMKSIS LQDVPHLRPH DKDATSKYLI EQVEEMIRDA NEETKQKLAD DGEGDMVAEL 360
  361 PKPLIRLRVD YSAPSNTQSP IDYQVENPRR FSNRFVGRVA NGNNVVQFYK KRSPVTRSKK 420
  421 SGINGTSISD RDVEKLFSES GGELEVQTLV NDLLNKMQLS LLPEVGLNEA VKKFVDKDEK 480
  481 TALKEFISHE ISNEVGILST NEEFLRTDDA EEMKALIKQV KRANSVRPTP PKENDETNFA 540
  541 FNGNGLDSFR SSNREVRTGS PDITQSHVDN ESRITHISQA ESSKPTSKPK RVRTATKKKI 600
  601 PAFSDSTVIS DAENELGDNN DAQDDVDIDE NDIIMVSTDE EDASYGLLNG RKTKTKTRPA 660
  661 ASTKTASRRG KGRASRTPKT DILGSLLAKK RK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MRE11 XRS2
    View Details (MIPS) Mewes HW, et al. (2004) MRE11 RAD50 XRS2
    View Details Krogan NJ, et al. (2006) DMC1 MRE11 RAD50 XRS2 YBL044W
    View Details Ho Y, et al. (2002) AHP1 CDC16 DUN1 ERG20 GPH1 MAM33 MKT1 MRE11 RAD50 REX2 RPT3 SEC27 TFP1 VMA8 XRS2
    View Details Qiu et al. (2008) MRE11 XRS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MRE11 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..271]
    [292..314]    		 PSI-BLAST 100.10721 Mre11
    2 View Details [272..291]
    [315..422]    		 PSI-BLAST 100.10721 Mre11
    3 View Details [423..692] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.78838275355792 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.72108778738758 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.23036240099336 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.00383731238803 bayes_pls_golite062009
  • phosphatase activity
    		•  0.887417749186372 bayes_pls_golite062009
  • protein binding
    		•  0.283905381578004 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle