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View Structure Prediction Details

Protein: MRE11
Organism: Saccharomyces cerevisiae
Length: 692 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRE11.

Description E-value Query
Range		 Subject
Range
MRE11_YEAST - Double-strand break repair protein MRE11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
MRE11 - Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-stra...
 0.0 [1..692] [1..692]
MRE11_MOUSE - Double-strand break repair protein MRE11A OS=Mus musculus GN=Mre11a PE=1 SV=1
 0.0 [5..661] [9..680]
MRE11_RAT - Double-strand break repair protein MRE11A OS=Rattus norvegicus GN=Mre11a PE=1 SV=1
 0.0 [5..661] [9..680]
MRE11A - MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
 0.0 [5..661] [9..682]
MRE11_CHICK - Double-strand break repair protein MRE11 OS=Gallus gallus GN=MRE11 PE=2 SV=1
 0.0 [5..676] [9..678]
MRE11_XENLA - Double-strand break repair protein MRE11 OS=Xenopus laevis GN=mre11 PE=2 SV=1
 0.0 [5..627] [10..604]
MRE11_ARATH - Double-strand break repair protein MRE11 OS=Arabidopsis thaliana GN=MRE11 PE=1 SV=1
 0.0 [7..679] [8..671]
gi|18496098 - gi|18496098|emb|CAD20051.1| Mre11 protein [Trypanosoma brucei]
 0.0 [8..678] [37..713]

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Predicted Domain #1
Region A:
Residues: [1-271] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYPDPDTIR ILITTDNHVG YNENDPITGD DSWKTFHEVM MLAKNNNVDM VVQSGDLFHV  60
   61 NKPSKKSLYQ VLKTLRLCCM GDKPCELELL SDPSQVFHYD EFTNVNYEDP NFNISIPVFG 120
  121 ISGNHDDASG DSLLCPMDIL HATGLINHFG KVIESDKIKV VPLLFQKGST KLALYGLAAV 180
  181 RDERLFRTFK DGGVTFEVPT MREGEWFNLM CVHQNHTGHT NTAFLPEQFL PDFLDMVIWG 240
  241 HEHECIPNLV HNPIKNFDVL QPGSSVATSL C

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [292-314] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMTPIPLETI RTFKMKSISL QDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 100.10721
Match: 1ii7A_
Description: Mre11
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 3.13006743434485 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.78838275355792 bayes_pls_golite062009
protein serine/threonine phosphatase activity 1.72108778738758 bayes_pls_golite062009
binding 1.44538582463569 bayes_pls_golite062009
catalytic activity 1.39852585255405 bayes_pls_golite062009
phosphoprotein phosphatase activity 1.23036240099336 bayes_pls_golite062009
phosphoric ester hydrolase activity 1.00383731238803 bayes_pls_golite062009
phosphatase activity 0.887417749186372 bayes_pls_golite062009
protein binding 0.283905381578004 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [272-291] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAEAQPKYVF ILDIKYGEAP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [315-422] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHLRPHDKDA TSKYLIEQVE EMIRDANEET KQKLADDGEG DMVAELPKPL IRLRVDYSAP  60
   61 SNTQSPIDYQ VENPRRFSNR FVGRVANGNN VVQFYKKRSP VTRSKKSG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 100.10721
Match: 1ii7A_
Description: Mre11
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [423-692] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INGTSISDRD VEKLFSESGG ELEVQTLVND LLNKMQLSLL PEVGLNEAVK KFVDKDEKTA  60
   61 LKEFISHEIS NEVGILSTNE EFLRTDDAEE MKALIKQVKR ANSVRPTPPK ENDETNFAFN 120
  121 GNGLDSFRSS NREVRTGSPD ITQSHVDNES RITHISQAES SKPTSKPKRV RTATKKKIPA 180
  181 FSDSTVISDA ENELGDNNDA QDDVDIDEND IIMVSTDEED ASYGLLNGRK TKTKTRPAAS 240
  241 TKTASRRGKG RASRTPKTDI LGSLLAKKRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle