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Protein Overview: NOP2

General Information:
Name(s) found: NOP2 / YNL061W [SGD]
Description(s) found:
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  • gi|730166|sp|P40991.1|NOP2_YEAST RecName: Full=Putative ribosomal RNA methyltransferase Nop2; AltName: Full=Nucleolar protein 2 [NCBI NR]
  • gi|6324268|ref|NP_014338.1| Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; Nop2p [Saccharomyces [NCBI NR]
  • gi|576442|emb|CAA57979.1| Nop2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1301934|emb|CAA95934.1| NOP2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1098483|gb|AAA99650.1| Ynl2428p [NCBI NR]
  • gi|1093321|prf||2103264A nuclear protein [NCBI NR]
  • pir||A55188 nucleolar protein NOP2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Putative ribosomal RNA methyltransferase Nop2 OS=Saccharomyces cerevisiae GN=NOP2 PE=1 SV=1 [Swiss-Prot]
  • NOP2 Nucleolar protein [mips]
  • Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles [SGD]
  • NOP2, Chr XIV from 510536-512392 [yeast_orfs2]
  • Chr XIV from 510536-512392 [yeastorf3.fasta]
  • (P40991) Nucleolar protein NOP2 [4932.FASTACCERV.txt]
  • NOP2 SGDID:S0005005, Chr XIV from 510538-512394, Verified ORF [yeastflysequest.fasta]
  • NOP2 SGDID:S0005005, Chr XIV from 510539-512395, Verified ORF [10112005cervSGD.fasta]
  • Nop2p [Saccharomyces cerevisiae]gi|1301934|emb|CAA95934.1| NOP2 [Saccharomyces cerevisiae]gi|576442|emb|CAA57979.1| Nop2p [Saccharomyces cerevisiae]gi|730166|sp|P40991|NOP2_YEAST Nucleolar protein NOP2gi|1078161|pir||A55188 nucleolar protein NOP2 - ye [nrdb_11152004_Chlamydomonas]
  • NOP2 SGDID:S000005005, Chr XIV from 510541-512397, Verified ORF, "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribo [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • NOP2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ynl2428p [nr-271106-contam.fasta]
  • Nop2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Nucleolar protein 2 [nr-271106-contam.fasta]
  • nuclear protein [nr-271106-contam.fasta]
  • Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; Nop2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NOP2 SGDID:S000005005, Chr XIV from 510542-512398, Verified ORF, "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribo [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • NOP2 SGDID:S000005005, Chr XIV from 510541-512397, Verified ORF, "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • NOP2 SGDID:S000005005, Chr XIV from 510542-512398, Verified ORF, "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles" [SGDyeast.20101221.fasta]
  • Putative ribosomal RNA methyltransferase Nop2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NOP2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NOP2 SGDID:S000005005, Chr XIV from 510540-512396, Genome Release 64-1-1, Verified ORF, "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles" [yeast-030211-contam.fasta]
  • NOP2 SGDID:S000005005, Chr XIV from 510540-512396, Genome Release 64-2-1, Verified ORF, "rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA while Rcm1p methylates cytosine at position 2278; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; homolog of p120/NSUN1, a human gene upregulated in cancer" [20141208_orf_trans.fasta]
  • YNL061W SGDID:S000005005, Chr XIV from 510540-512396, Genome Release 64-1-1, Verified ORF, "Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • 25S rRNA (cytosine(2870)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NOP2 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Saccharomyces cerevisiae
    Length: 618 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [TASLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [TASLink to PubMed article]
    Molecular Function: RNA methyltransferase activity [TASLink to PubMed article]
    S-adenosylmethionine-dependent methyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSRRHKNKQ AAPPTLEEFQ ARKEKKANRK LEKGKRPSTT QGDEVSDRKK KKSKPFKKSR  60
   61 KEEEEVVEED KDLPEVDLEE LSKARKSLFD DEEDDDEAGL VDEELKDEFD LEQEYDYDED 120
  121 EDNDAHPIFS DDDDEADLEE LNAQNMEALS KKLDEEEAEE AEEAEMELVE AENMQPRADI 180
  181 LPTEEQEEMM AQETPNLTST RTRMIEIVKV LENFKTLGAE GRSRGEYVDR LLKDICEYFG 240
  241 YTPFLAEKLF NLFSPAEAME FFEANEIARP ITIRTNTLKT RRRDLAQTLV NRGVNLQPIG 300
  301 SWTKVGLQIF DSQVPIGATP EYLAGHYILQ AASSFLPVIA LDPHENERIL DMAAAPGGKT 360
  361 TYISAMMKNT GCVFANDANK SRTKSLIANI HRLGCTNTIV CNYDAREFPK VIGGFDRILL 420
  421 DAPCSGTGVI GKDQSVKVSR TEKDFIQIPH LQKQLLLSAI DSVDCNSKHG GVIVYSTCSV 480
  481 AVEEDEAVID YALRKRPNVK LVDTGLAIGK EAFTSYRGKK FHPSVKLARR YYPHTYNVDG 540
  541 FFVAKFQKIG PSSFDDNQAS AKEKETAARK EALEEGIIHS DFATFEDEED DKYIEKSVKN 600
  601 NLLKKGVNPK AKRPSNEK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CIC1 DBP10 DBP9 DRS1 EBP2 ERB1 FPR4 HAS1 KRI1 LOC1 MAK21 MAK5 MRT4 NIP7 NOC2 NOC3 NOG1 NOP12 NOP15 NOP2 NOP4 NOP53 NOP7 NSA1 NUG1 PUF6 PWP1 RIX1 RIX7 RLP7 RPF1 RPF2 RPL25 RPL5 RPL6A RRP12 RRP5 SPB1 SPB4 TIF6 URB1 YTM1
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2006) ARX1 FPR4 MRT4 NIP7 NOG1 NOG2 NOP2 NSA2 NUG1 RPF2 SDA1 TIF6
    View Details Gavin AC, et al. (2002) AAR2 ARX1 BEM2 BMS1 BRX1 BUD20 CBF5 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 FUN12 GAR1 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRR1 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRP7 MRT4 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NSA1 NSA2 NUG1 POL2 PRP4 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SNU114 SNU13 SNU66 SPB1 SPB4 SRO9 SSF1 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP20 UTP21 UTP22 YGL036W YMR310C YTM1
    View Details Ho Y, et al. (2002) ACO1 ADH2 ATG7 BRX1 CBF5 CBP2 CDC16 CDC33 CIC1 CKA1 CKA2 CKB1 CKB2 COX6 DBP10 DBP2 DBP7 DNL4 DRS1 EBP2 EGD1 ENP2 ERB1 EXG1 FET4 FPR3 FPR4 GAR1 GDE1 HAS1 HHF1, HHF2 HHT1, HHT2 HOT1 HTA1 HTB1 HTB2 HUL5 KAP95 KGD1 KRE33 KRI1 KRR1 LOC1 MAK11 MAK16 MAK5 MES1 MGM101 MKT1 MMS4 MNP1 MRPL1 MRT4 MSS116 MUS81 NHP2 NIP7 NMD3 NOC2 NOC3 NOG1 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PDI1 PHO84 PIB2 POB3 POL2 PUF6 PWP1 RAD53 RLP7 RPC10 RPF2 RRP1 RRP14 RRP17 RRP5 RRT6 SCS2 SEC23 SFP1 SPT16 SSF1 TAF14 THI21 TIF1, TIF2 TIF4631 TIF6 TRL1 TSR1 UBI4 ULS1 UTP22 VMR1 VPS73 WTM2 YER084W YHB1 YPL009C YRA1 YTM1
    View Details Qiu et al. (2008) AIR1 BRX1 FPR4 GAR1 HCA4 KRR1 MRT4 NOP1 NOP2 NOP7 NSR1 NUG1 PXR1 RRP8 TGS1 UTP15 UTP4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOP2 Huh WK, et al. (2003)
    View Data NOP2 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] MSA 28.071997 View MSA. No confident structure predictions are available.
    2 View Details [216..311] MSA 3.163984 View MSA. No confident structure predictions are available.
    3 View Details [312..618] PSI-BLAST 270.917458 No description for 1j4fA_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • rRNA (guanine) methyltransferase activity
    		•  3.42580501977103 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.15840198589582 bayes_pls_golite062009
  • methyltransferase activity
    		•  3.08059259177729 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.99781997782052 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.89157295612945 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  2.57273894921779 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  2.26670816231281 bayes_pls_golite062009
  • RNA binding
    		•  1.99752836873461 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.55242772787972 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • transferase activity
    		•  1.07321114919891 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.03293084629981 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.954020631547781 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.742142092552002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • rRNA (uridine-2'-O-)-methyltransferase activity
    		•  0.15443733645953 bayes_pls_golite062009
  • mRNA binding
    		•  0.0540207721800283 bayes_pls_golite062009
  • snoRNA binding
    		•  0.00848192089639488 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle