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View Structure Prediction Details

Protein: NOP2
Organism: Saccharomyces cerevisiae
Length: 618 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOP2.

Description E-value Query
Range
Subject
Range
gi|207341676 - gi|207341676|gb|EDZ69664.1| YNL061Wp-like protein [Saccharomyces cerevisiae AWRI1631]
NOP2 - Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and la...
gi|190409050 - gi|190409050|gb|EDV12315.1| nucleolar protein NOP2 [Saccharomyces cerevisiae RM11-1a]
NOP2_YEAST - 25S rRNA (cytosine(2870)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
0.0 [1..618] [1..618]
gi|189422 - gi|189422|gb|AAA36398.1| proliferating cell nuclear protein P120
0.0 [6..580] [60..634]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [6..580] [8..567]
NOP2_MOUSE - Probable 28S rRNA (cytosine-C(5))-methyltransferase OS=Mus musculus GN=Nop2 PE=1 SV=1
0.0 [6..580] [47..606]
SPBP8B7.20c - RNA methyltransferase Nop2
NOP2_SCHPO - 25S rRNA (cytosine-C(5))-methyltransferase nop2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2484...
0.0 [4..613] [3..607]
gi|17979390, gi|... - gi|22328952|ref|NP_194390.2| nucleolar protein, putative [Arabidopsis thaliana], gi|22136852|gb|AAM9...
0.0 [3..599] [7..586]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSRRHKNKQ AAPPTLEEFQ ARKEKKANRK LEKGKRPSTT QGDEVSDRKK KKSKPFKKSR  60
   61 KEEEEVVEED KDLPEVDLEE LSKARKSLFD DEEDDDEAGL VDEELKDEFD LEQEYDYDED 120
  121 EDNDAHPIFS DDDDEADLEE LNAQNMEALS KKLDEEEAEE AEEAEMELVE AENMQPRADI 180
  181 LPTEEQEEMM AQETPNLTST RTRMIEIVKV LENFK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [216-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLGAEGRSRG EYVDRLLKDI CEYFGYTPFL AEKLFNLFSP AEAMEFFEAN EIARPITIRT  60
   61 NTLKTRRRDL AQTLVNRGVN LQPIGSWTKV GLQIFD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [312-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQVPIGATPE YLAGHYILQA ASSFLPVIAL DPHENERILD MAAAPGGKTT YISAMMKNTG  60
   61 CVFANDANKS RTKSLIANIH RLGCTNTIVC NYDAREFPKV IGGFDRILLD APCSGTGVIG 120
  121 KDQSVKVSRT EKDFIQIPHL QKQLLLSAID SVDCNSKHGG VIVYSTCSVA VEEDEAVIDY 180
  181 ALRKRPNVKL VDTGLAIGKE AFTSYRGKKF HPSVKLARRY YPHTYNVDGF FVAKFQKIGP 240
  241 SSFDDNQASA KEKETAARKE ALEEGIIHSD FATFEDEEDD KYIEKSVKNN LLKKGVNPKA 300
  301 KRPSNEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 270.917458
Match: 1j4fA_
Description: No description for 1j4fA_ was found.

Predicted functions:

Term Confidence Notes
rRNA (guanine) methyltransferase activity 3.42580501977103 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.15840198589582 bayes_pls_golite062009
methyltransferase activity 3.08059259177729 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.99781997782052 bayes_pls_golite062009
rRNA methyltransferase activity 2.89157295612945 bayes_pls_golite062009
RNA methyltransferase activity 2.57273894921779 bayes_pls_golite062009
N-methyltransferase activity 2.26670816231281 bayes_pls_golite062009
RNA binding 1.99752836873461 bayes_pls_golite062009
tRNA methyltransferase activity 1.55242772787972 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
transferase activity 1.07321114919891 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 1.03293084629981 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.954020631547781 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
rRNA (uridine) methyltransferase activity 0.742142092552002 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
rRNA (uridine-2'-O-)-methyltransferase activity 0.15443733645953 bayes_pls_golite062009
mRNA binding 0.0540207721800283 bayes_pls_golite062009
snoRNA binding 0.00848192089639488 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle