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View Structure Prediction Details

Protein: NOP2
Organism: Saccharomyces cerevisiae
Length: 618 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOP2.

Description E-value Query
Range
Subject
Range
gi|207341676 - gi|207341676|gb|EDZ69664.1| YNL061Wp-like protein [Saccharomyces cerevisiae AWRI1631]
NOP2 - Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and la...
gi|190409050 - gi|190409050|gb|EDV12315.1| nucleolar protein NOP2 [Saccharomyces cerevisiae RM11-1a]
NOP2_YEAST - 25S rRNA (cytosine(2870)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
0.0 [1..618] [1..618]
gi|189422 - gi|189422|gb|AAA36398.1| proliferating cell nuclear protein P120
0.0 [6..580] [60..634]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [6..580] [8..567]
NOP2_MOUSE - Probable 28S rRNA (cytosine-C(5))-methyltransferase OS=Mus musculus GN=Nop2 PE=1 SV=1
0.0 [6..580] [47..606]
SPBP8B7.20c - RNA methyltransferase Nop2
NOP2_SCHPO - 25S rRNA (cytosine-C(5))-methyltransferase nop2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2484...
0.0 [4..613] [3..607]
gi|17979390, gi|... - gi|22328952|ref|NP_194390.2| nucleolar protein, putative [Arabidopsis thaliana], gi|22136852|gb|AAM9...
0.0 [3..599] [7..586]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSRRHKNKQ AAPPTLEEFQ ARKEKKANRK LEKGKRPSTT QGDEVSDRKK KKSKPFKKSR  60
   61 KEEEEVVEED KDLPEVDLEE LSKARKSLFD DEEDDDEAGL VDEELKDEFD LEQEYDYDED 120
  121 EDNDAHPIFS DDDDEADLEE LNAQNMEALS KKLDEEEAEE AEEAEMELVE AENMQPRADI 180
  181 LPTEEQEEMM AQETPNLTST RTRMIEIVKV LENFK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [216-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLGAEGRSRG EYVDRLLKDI CEYFGYTPFL AEKLFNLFSP AEAMEFFEAN EIARPITIRT  60
   61 NTLKTRRRDL AQTLVNRGVN LQPIGSWTKV GLQIFD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.692 0.438 RNA methyltransferase activity c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.757 0.058 RNA methyltransferase activity c.23.1 CheY-like
View Download 0.731 0.032 RNA methyltransferase activity c.30.1 PreATP-grasp domain
View Download 0.664 0.026 RNA methyltransferase activity c.95.1 Thiolase-like
View Download 0.746 0.011 RNA methyltransferase activity a.60.2 RuvA domain 2-like
View Download 0.524 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.484 N/A N/A d.95.2 Homing endonucleases
View Download 0.441 N/A N/A a.77.1 DEATH domain
View Download 0.417 N/A N/A d.68.5 C-terminal domain of ProRS
View Download 0.403 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.402 N/A N/A d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.392 N/A N/A d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.376 N/A N/A a.60.12 DNA polymerase beta-like, second domain
View Download 0.376 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.350 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.342 N/A N/A d.68.3 SirA-like
View Download 0.336 N/A N/A d.58.5 GlnB-like
View Download 0.313 N/A N/A a.83.1 Guanido kinase N-terminal domain
View Download 0.307 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.305 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.305 N/A N/A c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.279 N/A N/A d.58.17 Metal-binding domain
View Download 0.275 N/A N/A d.120.1 Cytochrome b5
View Download 0.272 N/A N/A d.93.1 SH2 domain
View Download 0.270 N/A N/A d.68.7 R3H domain
View Download 0.268 N/A N/A a.138.1 Multiheme cytochromes
View Download 0.266 N/A N/A a.68.1 Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
View Download 0.264 N/A N/A c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.264 N/A N/A d.58.17 Metal-binding domain
View Download 0.262 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.260 N/A N/A a.59.1 PAH2 domain
View Download 0.259 N/A N/A d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.247 N/A N/A a.77.1 DEATH domain
View Download 0.244 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.243 N/A N/A d.68.3 SirA-like
View Download 0.233 N/A N/A d.95.2 Homing endonucleases
View Download 0.232 N/A N/A d.58.2 Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
View Download 0.231 N/A N/A d.79.3 L30e-like
View Download 0.227 N/A N/A d.58.1 4Fe-4S ferredoxins
View Download 0.225 N/A N/A c.55.5 MTH1175-like
View Download 0.223 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.218 N/A N/A a.2.3 Chaperone J-domain
View Download 0.215 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.211 N/A N/A c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.211 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.211 N/A N/A c.33.1 Cysteine hydrolase
View Download 0.204 N/A N/A a.60.9 lambda integrase-like, N-terminal domain

Predicted Domain #3
Region A:
Residues: [312-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQVPIGATPE YLAGHYILQA ASSFLPVIAL DPHENERILD MAAAPGGKTT YISAMMKNTG  60
   61 CVFANDANKS RTKSLIANIH RLGCTNTIVC NYDAREFPKV IGGFDRILLD APCSGTGVIG 120
  121 KDQSVKVSRT EKDFIQIPHL QKQLLLSAID SVDCNSKHGG VIVYSTCSVA VEEDEAVIDY 180
  181 ALRKRPNVKL VDTGLAIGKE AFTSYRGKKF HPSVKLARRY YPHTYNVDGF FVAKFQKIGP 240
  241 SSFDDNQASA KEKETAARKE ALEEGIIHSD FATFEDEEDD KYIEKSVKNN LLKKGVNPKA 300
  301 KRPSNEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 270.917458
Match: 1j4fA_
Description: No description for 1j4fA_ was found.

Predicted functions:

Term Confidence Notes
rRNA (guanine) methyltransferase activity 3.42580501977103 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.15840198589582 bayes_pls_golite062009
methyltransferase activity 3.08059259177729 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.99781997782052 bayes_pls_golite062009
rRNA methyltransferase activity 2.89157295612945 bayes_pls_golite062009
RNA methyltransferase activity 2.57273894921779 bayes_pls_golite062009
N-methyltransferase activity 2.26670816231281 bayes_pls_golite062009
RNA binding 1.99752836873461 bayes_pls_golite062009
tRNA methyltransferase activity 1.55242772787972 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
transferase activity 1.07321114919891 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 1.03293084629981 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.954020631547781 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
rRNA (uridine) methyltransferase activity 0.742142092552002 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
rRNA (uridine-2'-O-)-methyltransferase activity 0.15443733645953 bayes_pls_golite062009
mRNA binding 0.0540207721800283 bayes_pls_golite062009
snoRNA binding 0.00848192089639488 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle