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Protein Overview: UBI4

General Information:
Name(s) found: UBI4 / YLL039C [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 381 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: protein deubiquitination [TASLink to PubMed article]
    ascospore formation [TASLink to PubMed article]
    protein polyubiquitination [TASLink to PubMed article]
    protein monoubiquitination [TASLink to PubMed article]
    response to stress [TASLink to PubMed article]
    protein ubiquitination [IMPLink to PubMed article]
    Molecular Function: protein tag [ISSLink to PubMed article]
    ATP-dependent protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQIFVKTLTG KTITLEVESS DTIDNVKSKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN  60
   61 IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVESSDTID NVKSKIQDKE GIPPDQQRLI 120
  121 FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE SSDTIDNVKS 180
  181 KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT 240
  241 ITLEVESSDT IDNVKSKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR 300
  301 LRGGMQIFVK TLTGKTITLE VESSDTIDNV KSKIQDKEGI PPDQQRLIFA GKQLEDGRTL 360
  361 SDYNIQKEST LHLVLRLRGG N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADH2 ADR1 AHP1 ARF1 ARP2 ARP7 ATP3 BBC1 BEM2 BFR2 BIR1 BNA5 CAR2 CDC16 CDC33 CDC39 CDC53 CDC7 COF1 COP1 CPR1 CRM1 DIG1 DIG2 DMA1 DMA2 DSK2 DUF1 DUN1 DUR1,2 ECM10 ECM29 ECM33 EDE1 ELC1 ERB1 ERG1 FAA4 FAR1 FET4 FOL2 FPR3 GAL3 GAL83 GCN1 GFA1 GIS4 GPD1 GPD2 GRR1 GUF1 GUS1 GYP5 HAS1 HHF1, HHF2 HMF1 HOM6 HRT1 HRT3 HTB2 HXT6 HYP2 IDH1 JIP3 KRE33 KRI1 KSS1 LHS1 LOC1 LSP1 MCM4 MDM30 MDN1 MES1 MET30 MET4 MKT1 MMS1 MMS4 MSE1 MUS81 MYO2 NAP1 NHP2 NIP1 NOP12 NOP2 NPL4 NUT1 PDC5 PDC6 PFK1 PHO84 PIB1 PIL1 PIM1 PMA1 PMA2 POR1 PRB1 PST2 PWP1 PYC1 RAD1 RAD23 RAD53 RAD7 RGC1 RNR2 RPA135 RPA190 RPC10 RPC19 RPF2 RPG1 RPN1 RPN10 RPT2 RPT4 RVB1 RVS167 SAH1 SAN1 SAR1 SAW1 SEC23 SEC27 SEC6 SEN1 SES1 SHP1 SKP1 SNF1 SNF4 SRP1 SRV2 STE12 STE20 STE7 STI1 SWD1 TAF14 TEC1 THI3 TIF34 TIF35 TPS1 TSL1 UBC7 UBI4 UBP7 UFD2 UTP22 VAC14 VPS13 YAR009C YDR049W YDR239C YGP1 YHB1 YHR033W YLR035C-A YNL311C YPL113C YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run RIX7 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #09 Alpha Factor Prep4-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD23 UBI4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UBI4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] PSI-BLAST 181.68867 Nedd8
    2 View Details [77..150] ORFEUS 14.91 Nedd8
    3 View Details [151..215] PSI-BLAST 193.37734 Ubiquitin
    4 View Details [216..304] PSI-BLAST 337.07631 Ubiquitin
    5 View Details [305..381] ORFEUS 13.19 Ubiquitin-like N-terminal domain of PLIC-2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  7.96815122865454 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  7.5865326390755 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.96506647680367 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.87890364671564 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  5.80275625219016 bayes_pls_golite062009
  • structural molecule activity
    		•  5.37716040292459 bayes_pls_golite062009
  • ligase activity
    		•  2.98370000660434 bayes_pls_golite062009
  • protein binding
    		•  2.9188688008729 bayes_pls_golite062009
  • binding
    		•  2.786655943372 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21955949922709 bayes_pls_golite062009
  • tubulin binding
    		•  2.21127283188349 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20811136250556 bayes_pls_golite062009
  • protein tag
    		•  2.15059229834935 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9984951714209 bayes_pls_golite062009
  • microtubule binding
    		•  1.92602521631666 bayes_pls_golite062009
  • DNA binding
    		•  1.86539227646379 bayes_pls_golite062009
  • receptor binding
    		•  1.09091623056284 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.06193722939839 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.80391127659342 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.62324312069889 bayes_pls_golite062009
  • hydrolase activity
    		•  0.614233748923048 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.536856055841234 bayes_pls_golite062009
  • kinase activity
    		•  0.506057697290914 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.410719674374641 bayes_pls_golite062009
  • RNA binding
    		•  0.359926300264681 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  0.27796076785312 bayes_pls_golite062009
  • enzyme binding
    		•  0.240262781026149 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  0.189489510504993 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0788219117963673 bayes_pls_golite062009
    2
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  7.77976521481104 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  7.45825282569124 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.82424077726436 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.78164148882937 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  5.77326793355348 bayes_pls_golite062009
  • structural molecule activity
    		•  5.36311620867914 bayes_pls_golite062009
  • ligase activity
    		•  2.93949076291021 bayes_pls_golite062009
  • protein binding
    		•  2.78014377544701 bayes_pls_golite062009
  • binding
    		•  2.70872150536621 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23822335492051 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.11984570584255 bayes_pls_golite062009
  • tubulin binding
    		•  2.03607606145909 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.02209816078273 bayes_pls_golite062009
  • DNA binding
    		•  1.8833926783115 bayes_pls_golite062009
  • microtubule binding
    		•  1.75926256048235 bayes_pls_golite062009
  • protein tag
    		•  1.64936739586738 bayes_pls_golite062009
  • receptor binding
    		•  1.07983643886476 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.04462787665591 bayes_pls_golite062009
  • hydrolase activity
    		•  0.633589926944629 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.624731467637361 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.549761413791307 bayes_pls_golite062009
  • kinase activity
    		•  0.520011006272513 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.469920108401949 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.426082194130922 bayes_pls_golite062009
  • RNA binding
    		•  0.3655923364304 bayes_pls_golite062009
  • protein kinase activity
    		•  0.336252604607827 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  0.270602640718893 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  0.181054590240182 bayes_pls_golite062009
  • enzyme binding
    		•  0.147520546067615 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0623044995795676 bayes_pls_golite062009
    3
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  7.96815122865454 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  7.5865326390755 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.96506647680367 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.87890364671564 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  5.80275625219016 bayes_pls_golite062009
  • structural molecule activity
    		•  5.37716040292459 bayes_pls_golite062009
  • ligase activity
    		•  2.98370000660434 bayes_pls_golite062009
  • protein binding
    		•  2.9188688008729 bayes_pls_golite062009
  • binding
    		•  2.786655943372 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21955949922709 bayes_pls_golite062009
  • tubulin binding
    		•  2.21127283188349 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20811136250556 bayes_pls_golite062009
  • protein tag
    		•  2.15059229834935 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9984951714209 bayes_pls_golite062009
  • microtubule binding
    		•  1.92602521631666 bayes_pls_golite062009
  • DNA binding
    		•  1.86539227646379 bayes_pls_golite062009
  • receptor binding
    		•  1.09091623056284 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.06193722939839 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.80391127659342 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.62324312069889 bayes_pls_golite062009
  • hydrolase activity
    		•  0.614233748923048 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.536856055841234 bayes_pls_golite062009
  • kinase activity
    		•  0.506057697290914 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.410719674374641 bayes_pls_golite062009
  • RNA binding
    		•  0.359926300264681 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  0.27796076785312 bayes_pls_golite062009
  • enzyme binding
    		•  0.240262781026149 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  0.189489510504993 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0788219117963673 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  7.96815122865454 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  7.5865326390755 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.96506647680367 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.87890364671564 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  5.80275625219016 bayes_pls_golite062009
  • structural molecule activity
    		•  5.37716040292459 bayes_pls_golite062009
  • ligase activity
    		•  2.98370000660434 bayes_pls_golite062009
  • protein binding
    		•  2.9188688008729 bayes_pls_golite062009
  • binding
    		•  2.786655943372 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21955949922709 bayes_pls_golite062009
  • tubulin binding
    		•  2.21127283188349 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20811136250556 bayes_pls_golite062009
  • protein tag
    		•  2.15059229834935 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9984951714209 bayes_pls_golite062009
  • microtubule binding
    		•  1.92602521631666 bayes_pls_golite062009
  • DNA binding
    		•  1.86539227646379 bayes_pls_golite062009
  • receptor binding
    		•  1.09091623056284 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.06193722939839 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.80391127659342 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.62324312069889 bayes_pls_golite062009
  • hydrolase activity
    		•  0.614233748923048 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.536856055841234 bayes_pls_golite062009
  • kinase activity
    		•  0.506057697290914 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.410719674374641 bayes_pls_golite062009
  • RNA binding
    		•  0.359926300264681 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  0.27796076785312 bayes_pls_golite062009
  • enzyme binding
    		•  0.240262781026149 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  0.189489510504993 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0788219117963673 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle