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Protein Overview: SWD1

General Information:
Name(s) found: SWD1 / YAR003W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 426 amino acids

    Gene Ontology:
    Cellular Component: Set1C/COMPASS complex [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: histone methylation [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: histone methyltransferase activity (H3-K4 specific) [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL VIYDMDTFRP  60
   61 ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD LSKPSKPLKE IRFDSPIWGC 120
  121 QWLDAKRRLC VATIFEESDA YVIDFSNDPV ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH 180
  181 PNIIIVGTSK GWLDFYKFHS LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ 240
  241 YEISIDDENS AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT 300
  301 SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA LAPDFEEVEE 360
  361 NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD VRGNNLLVER FTIPTDYTRI 420
  421 IKMQSS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRE2 SDC1 SET1 SHG1 SPP1 SWD1 SWD2 SWD3
    View Details Krogan NJ, et al. (2006) BRE2 ERF2 SDC1 SET1 SHG1 SPP1 SWD1 SWD3 YHI9 YLL023C
    View Details Gavin AC, et al. (2006) BRE2 SDC1 SET1 SPP1 SWD1 SWD3
    View Details Gavin AC, et al. (2002) BRE2 DOA4 RSM7 SDC1 SET1 SPP1 SSZ1 SWD1 SWD3
    View Details Ho Y, et al. (2002) RNR2 SWD1 UBI4
    View Details Qiu et al. (2008) BRE2 SDC1 SET1 SPP1 SWD1 SWD2 SWD3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SWD1 Sundin BA, et al. (2004)
    View Data SWD1 Sundin BA, et al. (2004)
    View Data SWD1 Sundin BA, et al. (2004)
    View Data SWD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..343] PSI-BLAST 97.228787 Tup1, C-terminal domain
    2 View Details [344..426] PSI-BLAST 2.221849 TolB, C-terminal domain; TolB, N-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle