YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: BRE2

General Information:
Name(s) found: BRE2 / YLR015W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: Set1C/COMPASS complex [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: transcription [ISSLink to PubMed article]
    histone methylation [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: histone methyltransferase activity (H3-K4 specific) [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    transcription regulator activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLGIIPYQE GTDIVYKNAL QGQQEGKRPN LPQMEATHQI KSSVQGTSYE FVRTEDIPLN  60
   61 RRHFVYRPCS ANPFFTILGY GCTEYPFDHS GMSVMDRSEG LSISRDGNDL VSVPDQYGWR 120
  121 TARSDVCIKE GMTYWEVEVI RGGNKKFADG VNNKENADDS VDEVQSGIYE KMHKQVNDTP 180
  181 HLRFGVCRRE ASLEAPVGFD VYGYGIRDIS LESIHEGKLN CVLENGSPLK EGDKIGFLLS 240
  241 LPSIHTQIKQ AKEFTKRRIF ALNSHMDTMN EPWREDAENG PSRKKLKQET TNKEFQRALL 300
  301 EDIEYNDVVR DQIAIRYKNQ LFFEATDYVK TTKPEYYSSD KRERQDYYQL EDSYLAIFQN 360
  361 GKYLGKAFEN LKPLLPPFSE LQYNEKFYLG YWQHGEARDE SNDKNTTSAK KKKQQQKKKK 420
  421 GLILRNKYVN NNKLGYYPTI SCFNGGTARI ISEEDKLEYL DQIRSAYCVD GNSKVNTLDT 480
  481 LYKEQIAEDI VWDIIDELEQ IALQQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRE2 SDC1 SET1 SHG1 SPP1 SWD1 SWD2 SWD3
    View Details Krogan NJ, et al. (2006) BRE2 ERF2 SDC1 SET1 SHG1 SPP1 SWD1 SWD3 YHI9 YLL023C
    View Details Gavin AC, et al. (2006) BRE2 SDC1 SET1 SPP1 SWD1 SWD3
    View Details Gavin AC, et al. (2002) BRE2 DOA4 RSM7 SDC1 SET1 SPP1 SSZ1 SWD1 SWD3
    View Details Ho Y, et al. (2002) BRE2 SET1
    View Details Qiu et al. (2008) BRE2 SDC1 SET1 SHG1 SPP1 SWD1 SWD2 SWD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BRE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..275] MSA 3.009939 View MSA. No confident structure predictions are available.
    2 View Details [276..505] deduced N/A No confident structure predictions are available.
    3 View Details [293..505] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.36160381896665 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.17920418295591 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9830722589036 bayes_pls_golite062009
  • DNA binding
    		•  1.82525586215701 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.26658862258675 bayes_pls_golite062009
  • transcription factor activity
    		•  1.16784442642933 bayes_pls_golite062009
  • protein binding
    		•  0.729859333703778 bayes_pls_golite062009
  • protein kinase activity
    		•  0.358328289529296 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.155087758481234 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.020584443202555 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle