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Protein Overview: OYE2

General Information:
Name(s) found: OYE2 / YHR179W [SGD]
Description(s) found:
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  • gi|6321973|ref|NP_012049.1| Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism; Oye2p [Saccharomyces ce [NCBI NR]
  • gi|458892|gb|AAB68024.1| Oye2p: NAD(P)H oxidoreductase (Old Yellow Enzyme) [Saccharomyces cerevisiae] [NCBI NR]
  • pir||A46009 NADPH2 dehydrogenase (EC 1.6.99.1) chain OYE2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|417432|sp|Q03558.3|OYE2_YEAST RecName: Full=NADPH dehydrogenase 2; AltName: Full=Old yellow enzyme 2 [NCBI NR]
  • gi|172030|gb|AAA83386.1| NAD(P)H:oxidoreductase [Saccharomyces cerevisiae] [NCBI NR]
  • NADPH dehydrogenase 2 OS=Saccharomyces cerevisiae GN=OYE2 PE=1 SV=3 [Swiss-Prot]
  • OYE2 NADPH dehydrogenase (old yellow enzyme), isoform 1 [mips]
  • Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism [SGD]
  • OYE2, Chr VIII from 462498-463700 [yeast_orfs2]
  • Chr VIII from 462498-463700 [yeastorf3.fasta]
  • OYE2 SGDID:S0001222, Chr VIII from 462500-463702, Verified ORF [yeastflysequest.fasta]
  • OYE2 SGDID:S0001222, Chr VIII from 462501-463703, Verified ORF [10112005cervSGD.fasta]
  • Oye2p [Saccharomyces cerevisiae]gi|417432|sp|Q03558|OYE2_YEAST NADPH dehydrogenase 2 (Old yellow enzyme 2)gi|422166|pir||A46009 NADPH2 dehydrogenase (EC 1.6.99.1) chain OYE2 - yeast (Saccharomyces cerevisiae)gi|458892|gb|AAB68024.1| Oye2p: NAD(P)H oxi [nrdb_11152004_Chlamydomonas]
  • OYE2 SGDID:S000001222, Chr VIII from 462502-463704, Verified ORF, "Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in ste [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Oye2p: NAD(P)H oxidoreductase (Old Yellow Enzyme) [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NADPH dehydrogenase 2 (Old yellow enzyme 2) [nr-271106-contam.fasta]
  • NAD(P)H:oxidoreductase [nr-271106-contam.fasta]
  • Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism; Oye2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • OYE2 SGDID:S000001222, Chr VIII from 462502-463704, Verified ORF, "Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • NADPH dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OYE2 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • OYE2 SGDID:S000001222, Chr VIII from 462502-463704, Genome Release 64-1-1, Verified ORF, "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death" [yeast-030211-contam.fasta]
  • OYE2 SGDID:S000001222, Chr VIII from 462502-463704, Genome Release 64-2-1, Verified ORF, "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YHR179W SGDID:S000001222, Chr VIII from 462502-463704, Genome Release 64-1-1, Verified ORF, "Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 400 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: NADPH dehydrogenase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFVKDFKPQ ALGDTNLFKP IKIGNNELLH RAVIPPLTRM RAQHPGNIPN RDWAVEYYAQ  60
   61 RAQRPGTLII TEGTFPSPQS GGYDNAPGIW SEEQIKEWTK IFKAIHENKS FAWVQLWVLG 120
  121 WAAFPDTLAR DGLRYDSASD NVYMNAEQEE KAKKANNPQH SITKDEIKQY VKEYVQAAKN 180
  181 SIAAGADGVE IHSANGYLLN QFLDPHSNNR TDEYGGSIEN RARFTLEVVD AVVDAIGPEK 240
  241 VGLRLSPYGV FNSMSGGAET GIVAQYAYVL GELERRAKAG KRLAFVHLVE PRVTNPFLTE 300
  301 GEGEYNGGSN KFAYSIWKGP IIRAGNFALH PEVVREEVKD PRTLIGYGRF FISNPDLVDR 360
  361 LEKGLPLNKY DRDTFYKMSA EGYIDYPTYE EALKLGWDKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAR2 OYE2
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Krogan NJ, et al. (2006) ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2
    View Details Ho Y, et al. (2002) AAC3 AAT2 ABP1 ACH1 ACO1 ADH2 AFR1 AHA1 AHP1 AIM21 AIM41 AIM46 APP1 APT1 ARC1 ARE1 ARF1 ARO1 ARO4 ARP2 ATP3 ATP4 BCK1 BEM2 BUD14 BUD20 CAR2 CDC15 CDC33 CIC1 CLU1 COF1 COR1 CPA2 CPR1 CPR6 CRZ1 CYR1 CYS4 DBP8 DCP1 DCP2 DNM1 DSS1 ECM10 EDC3 EDE1 EGD1 EGD2 EHD3 EMG1 ENP1 ERG13 ERG6 FET4 FOL2 FPR1 FRS2 FUN12 FYV8 GAL7 GAS1 GCD11 GCN3 GND1 GND2 GPH1 GPI15 GRS1 GRX1 GSP2 GUS1 HAS1 HEF3 HHF1, HHF2 HMO1 HOM3 HOR2 HRR25 HSP104 HTB1 HTB2 HXT7 HYP2 IDH1 ILV2 ILV5 IMD2 IMD3 IMD4 IPP1 KGD1 KIC1 KIN2 KRE33 KRI1 LHS1 LOC1 LRO1 LSM2 LSP1 LTV1 LYS12 MAG2 MAM33 MDH1 MDS3 MET6 MGE1 MGM101 MKK2 MKT1 MPC54 MRPS16 MSC3 MTC5 NAP1 NOC2 NOP12 NOP4 NPL3 NSA1 NTF2 NUG1 OLA1 OYE2 OYE3 PDC6 PEX19 PFK1 PGM2 PIL1 PIN4 PMA1 POR1 PRB1 PRE1 PRM2 PST2 PTC3 PTC4 PUF3 PUP3 PYC2 QCR2 RAD52 RAD59 RCN2 RHR2 RIO2 RLP24 RNR1 RNR2 RPC19 RPF2 RPM2 RPN1 RPN6 RPT3 RRP12 RSN1 SAH1 SAP185 SAP190 SAS10 SCP160 SEC2 SEC23 SEC26 SEC27 SEC53 SEN15 SES1 SFB3 SGM1 SIS1 SIT4 SKG3 SLT2 SMK1 SNU13 SOD1 SOD2 TEF4 THI22 THS1 TIF1, TIF2 TIF4631 TIF4632 TMA19 TMA29 TPS1 TRR1 TSA2 TSR1 UBA1 UTP20 UTP22 VMA4 VMA5 VMA8 WTM1 YBL108W YBR225W YCK1 YDL086W YER138C YFL006W YGK3 YHR033W YHR112C YKU80 YNK1 YPL150W YPT31
    View Details Qiu et al. (2008) ABP1 ACT1 COF1 OYE2 RVS167

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 OYE2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OYE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..400] PSI-BLAST 10123.0 Old yellow enzyme (OYE)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.50791144647902 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  2.11027907327307 bayes_pls_golite062009
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • coenzyme binding
    		•  0.99234662301893 bayes_pls_golite062009
  • binding
    		•  0.724672865863266 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.350068675013616 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.0276497014195508 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle