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Protein Overview: ACO1

General Information:
Name(s) found: ACO1 / YLR304C [SGD]
Description(s) found:
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  • gi|6323335|ref|NP_013407.1| Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; A [NCBI NR]
  • gi|596052|gb|AAB67348.1| Aco1p: Aconitate hydratase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1168308|sp|P19414.2|ACON_YEAST RecName: Full=Aconitate hydratase, mitochondrial; Short=Aconitase; AltName: Full=Citrate hydro-lyase; Flags: Precursor [NCBI NR]
  • pir||S50387 aconitate hydratase (EC 4.2.1.3) precursor - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Aconitate hydratase, mitochondrial OS=Saccharomyces cerevisiae GN=ACO1 PE=1 SV=2 [Swiss-Prot]
  • ACO1 Aconitate hydratase [mips]
  • Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy [SGD]
  • ACO1, Chr XII from 735212-737548, reverse complement [yeast_orfs2]
  • Chr XII from 735212-737548, reverse complement [yeastorf3.fasta]
  • Chr XII from 737548-735212, reverse complement [yeastorf5.fasta]
  • (P19414) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase) [4932.FASTACCERV.txt]
  • ACO1 SGDID:S0004295, Chr XII from 737550-735214, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Aco1p [Saccharomyces cerevisiae]gi|1168308|sp|P19414|ACON_YEAST Aconitate hydratase, mitochondrial precursor (Citrate hydro-lyase) (Aconitase)gi|596052|gb|AAB67348.1| Aconitate hydratasegi|1077349|pir||S50387 aconitate hydratase (EC 4.2.1.3) precursor [nrdb_11152004_Chlamydomonas]
  • ACO1 SGDID:S000004295, Chr XII from 737550-735214, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ACO1 SGDID:S000004295, Chr XII from 737550-735214, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitocho [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Aconitate hydratase, mitochondrial precursor (Citrate hydro-lyase) (Aconitase) [nr-271106-contam.fasta]
  • Aconitate hydratase [nr-271106-contam.fasta]
  • Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; Aco1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ACO1 SGDID:S000004295, Chr XII from 737550-735214, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy" [yeast-bovrabprots.fasta]
  • ACO1 SGDID:S000004295, Chr XII from 737550-735214, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Aconitate hydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACO1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ACO1 SGDID:S000004295, Chr XII from 737548-735212, Genome Release 64-1-1, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy" [yeast-030211-contam.fasta]
  • ACO1 SGDID:S000004295, Chr XII from 737548-735212, Genome Release 64-2-1, reverse complement, Verified ORF, "Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy" [20141208_orf_trans.fasta]
  • YLR304C SGDID:S000004295, Chr XII from 737548-735212, Genome Release 64-1-1, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 778 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cytosol [TASLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: glutamate biosynthetic process [TASLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    citrate metabolic process [TASLink to PubMed article]
    propionate metabolic process [IEPLink to PubMed article]
    tricarboxylic acid cycle [TASLink to PubMed article]
    mitochondrial genome maintenance [IMPLink to PubMed article]
    Molecular Function: aconitate hydratase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSARSAIKR PIVRGLATVS NLTRDSKVNQ NLLEDHSFIN YKQNVETLDI VRKRLNRPFT  60
   61 YAEKILYGHL DDPHGQDIQR GVSYLKLRPD RVACQDATAQ MAILQFMSAG LPQVAKPVTV 120
  121 HCDHLIQAQV GGEKDLKRAI DLNKEVYDFL ASATAKYNMG FWKPGSGIIH QIVLENYAFP 180
  181 GALIIGTDSH TPNAGGLGQL AIGVGGADAV DVMAGRPWEL KAPKILGVKL TGKMNGWTSP 240
  241 KDIILKLAGI TTVKGGTGKI VEYFGDGVDT FSATGMGTIC NMGAEIGATT SVFPFNKSMI 300
  301 EYLEATGRGK IADFAKLYHK DLLSADKDAE YDEVVEIDLN TLEPYINGPF TPDLATPVSK 360
  361 MKEVAVANNW PLDVRVGLIG SCTNSSYEDM SRSASIVKDA AAHGLKSKTI FTVTPGSEQI 420
  421 RATIERDGQL ETFKEFGGIV LANACGPCIG QWDRRDIKKG DKNTIVSSYN RNFTSRNDGN 480
  481 PQTHAFVASP ELVTAFAIAG DLRFNPLTDK LKDKDGNEFM LKPPHGDGLP QRGYDAGENT 540
  541 YQAPPADRST VEVKVSPTSD RLQLLKPFKP WDGKDAKDMP ILIKAVGKTT TDHISMAGPW 600
  601 LKYRGHLENI SNNYMIGAIN AENKKANCVK NVYTGEYKGV PDTARDYRDQ GIKWVVIGDE 660
  661 NFGEGSSREH AALEPRFLGG FAIITKSFAR IHETNLKKQG LLPLNFKNPA DYDKINPDDR 720
  721 IDILGLAELA PGKPVTMRVH PKNGKPWDAV LTHTFNDEQI EWFKYGSALN KIKADEKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACO1 BAT2 HSP42 NTH2 RRP12 SRS2 SSE2
    View Details Gavin AC, et al. (2006) ACO1 FAA4 MDH1 YHB1
    View Details Ho Y, et al. (2002) AAC3 AAT2 ABP1 ACH1 ACO1 ADH4 ADH6 AFR1 AHP1 AIM13 AIM41 ARC1 ARF1 ATP3 ATP4 BIO3 BUD14 CAR2 CCL1 CCT6 CDC14 CDC33 CIC1 CLU1 COF1 COR1 CPR1 CRZ1 CYR1 CYS4 DCP1 DCP2 DIG1 DIG2 DNL4 DNM1 ECM10 EDC3 EDE1 EGD1 EGD2 ELG1 ENP1 ERB1 ERG13 ERG20 ERG6 FPR1 FRS2 GAS1 GCN3 GDE1 GDI1 GND1 GND2 GPH1 GRX1 GUS1 HAS1 HEF3 HHF1, HHF2 HOR2 HRR25 HSP104 HTA1 HXT6 HXT7 HYP2 IPP1 KGD1 KSS1 LOC1 LRO1 LSC1 LSP1 LTV1 MAK16 MAM33 MDH1 MDS3 MEC1 MET18 MET6 MGE1 MRT4 MUB1 NAS2 NOC2 NOC3 NOG1 NOP15 NOP2 NOP7 NSA1 NTF2 NUG1 OLA1 OYE2 PEX19 PFK1 PIL1 PIN4 PRM2 PRP43 PTC4 PTC7 PUF3 QCR2 RAD26 RAD3 RFA1 RFC1 RFC2 RFC4 RHR2 RIO2 RNQ1 RNR2 RPC19 RPC82 RPF2 RPM2 RPN1 RPT3 RRT6 RSN1 SAH1 SAN1 SAP185 SAP190 SAS10 SCP160 SCS2 SEC2 SEC23 SEC53 SEN15 SES1 SFB3 SGM1 SIT4 SNU13 SOD1 SPB4 SPT16 SRP1 SSQ1 STE12 STE7 TEF4 TFP1 THI22 THS1 TIF1, TIF2 TIF6 TMA19 TMA29 TOP1 TSA2 TSR1 UBA1 UBR2 VMA4 VMA5 WTM1 YBR225W YER138C YNK1 YPT6 YSP2 YTM1
    View Details Qiu et al. (2008) ACO1 CIT1 FUM1 ICL2 RPO41

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ACO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..565]
    [597..608]    		 PSI-BLAST 11000.0 Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
    2 View Details [566..596]
    [609..778]    		 PSI-BLAST 11000.0 Aconitase A, C-terminal domain; Aconitase A, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-isopropylmalate dehydratase activity
    		•  11.6597692115322 bayes_pls_golite062009
  • aconitate hydratase activity
    		•  5.86356477922338 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.93956285477489 bayes_pls_golite062009
  • catalytic activity
    		•  2.4040324437254 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.25736437672211 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  2.08349115784849 bayes_pls_golite062009
  • hydro-lyase activity
    		•  2.04845291489052 bayes_pls_golite062009
  • lyase activity
    		•  2.0080619912194 bayes_pls_golite062009
  • metal cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • binding
    		•  1.67914740974449 bayes_pls_golite062009
  • DNA binding
    		•  1.6436451615422 bayes_pls_golite062009
  • iron-responsive element binding
    		•  1.1980380564483 bayes_pls_golite062009
  • iron ion binding
    		•  1.12961684198784 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  1.11810757572823 bayes_pls_golite062009
  • mRNA binding
    		•  1.0310744464034 bayes_pls_golite062009
  • structural molecule activity
    		•  0.870913754566634 bayes_pls_golite062009
  • RNA binding
    		•  0.42311333660604 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.342428816025605 bayes_pls_golite062009
  • protein binding
    		•  0.232638130896339 bayes_pls_golite062009
  • cation binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • metal ion binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • ion binding
    		•  0.0228992031160024 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle