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View Structure Prediction Details

Protein: ACO1
Organism: Saccharomyces cerevisiae
Length: 778 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACO1.

Description E-value Query
Range		 Subject
Range
gi|190405359 - gi|190405359|gb|EDV08626.1| aconitase [Saccharomyces cerevisiae RM11-1a]
ACON_YEAST - Aconitate hydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACO1 ...
gi|151940834 - gi|151940834|gb|EDN59216.1| aconitase [Saccharomyces cerevisiae YJM789]
ACO1 - Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitoc...
 0.0 [1..778] [1..778]
gi|108227 - pir||A35544 aconitate hydratase (EC 4.2.1.3) precursor, mitochondrial [validated] - pig
ACON_PIG - Aconitate hydratase, mitochondrial OS=Sus scrofa GN=ACO2 PE=1 SV=1
 0.0 [13..778] [17..781]
gi|109451582, gi... - gi|168277800|dbj|BAG10878.1| aconitate hydratase [synthetic construct], gi|123998321|gb|ABM86762.1| ...
ACO2 - aconitase 2, mitochondrial
 0.0 [13..777] [17..780]
ACON_MOUSE - Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1
 0.0 [13..777] [17..780]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [14..778] [18..781]
ACON_BOVIN - (P20004) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase)
 0.0 [14..777] [18..780]

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Predicted Domain #1
Region A:
Residues: [1-565] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSARSAIKR PIVRGLATVS NLTRDSKVNQ NLLEDHSFIN YKQNVETLDI VRKRLNRPFT  60
   61 YAEKILYGHL DDPHGQDIQR GVSYLKLRPD RVACQDATAQ MAILQFMSAG LPQVAKPVTV 120
  121 HCDHLIQAQV GGEKDLKRAI DLNKEVYDFL ASATAKYNMG FWKPGSGIIH QIVLENYAFP 180
  181 GALIIGTDSH TPNAGGLGQL AIGVGGADAV DVMAGRPWEL KAPKILGVKL TGKMNGWTSP 240
  241 KDIILKLAGI TTVKGGTGKI VEYFGDGVDT FSATGMGTIC NMGAEIGATT SVFPFNKSMI 300
  301 EYLEATGRGK IADFAKLYHK DLLSADKDAE YDEVVEIDLN TLEPYINGPF TPDLATPVSK 360
  361 MKEVAVANNW PLDVRVGLIG SCTNSSYEDM SRSASIVKDA AAHGLKSKTI FTVTPGSEQI 420
  421 RATIERDGQL ETFKEFGGIV LANACGPCIG QWDRRDIKKG DKNTIVSSYN RNFTSRNDGN 480
  481 PQTHAFVASP ELVTAFAIAG DLRFNPLTDK LKDKDGNEFM LKPPHGDGLP QRGYDAGENT 540
  541 YQAPPADRST VEVKVSPTSD RLQLL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [597-608] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGPWLKYRGH LE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 5acn__
Description: Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3-isopropylmalate dehydratase activity 11.6597692115322 bayes_pls_golite062009
aconitate hydratase activity 5.86356477922338 bayes_pls_golite062009
structural constituent of ribosome 2.93956285477489 bayes_pls_golite062009
catalytic activity 2.4040324437254 bayes_pls_golite062009
nucleic acid binding 2.25736437672211 bayes_pls_golite062009
carbon-oxygen lyase activity 2.08349115784849 bayes_pls_golite062009
hydro-lyase activity 2.04845291489052 bayes_pls_golite062009
lyase activity 2.0080619912194 bayes_pls_golite062009
metal cluster binding 1.70706327499066 bayes_pls_golite062009
iron-sulfur cluster binding 1.70706327499066 bayes_pls_golite062009
binding 1.67914740974449 bayes_pls_golite062009
DNA binding 1.6436451615422 bayes_pls_golite062009
iron-responsive element binding 1.1980380564483 bayes_pls_golite062009
iron ion binding 1.12961684198784 bayes_pls_golite062009
4 iron, 4 sulfur cluster binding 1.11810757572823 bayes_pls_golite062009
mRNA binding 1.0310744464034 bayes_pls_golite062009
structural molecule activity 0.870913754566634 bayes_pls_golite062009
RNA binding 0.42311333660604 bayes_pls_golite062009
transition metal ion binding 0.342428816025605 bayes_pls_golite062009
protein binding 0.232638130896339 bayes_pls_golite062009
cation binding 0.0272064751959212 bayes_pls_golite062009
metal ion binding 0.0272064751959212 bayes_pls_golite062009
ion binding 0.0228992031160024 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [566-596] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPFKPWDGKD AKDMPILIKA VGKTTTDHIS M

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [609-778] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NISNNYMIGA INAENKKANC VKNVYTGEYK GVPDTARDYR DQGIKWVVIG DENFGEGSSR  60
   61 EHAALEPRFL GGFAIITKSF ARIHETNLKK QGLLPLNFKN PADYDKINPD DRIDILGLAE 120
  121 LAPGKPVTMR VHPKNGKPWD AVLTHTFNDE QIEWFKYGSA LNKIKADEKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 5acn__
Description: Aconitase A, C-terminal domain; Aconitase A, N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle