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Catalysis of the breakage of a carbon-oxygen bond. Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: aconitate hydratase activity
Acc: GO:0003994
Aspect: Molecular Function
Desc: Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
Synonyms:
  • citrate(isocitrate) hydro-lyase activity
  • citrate hydro-lyase activity
  • cis-aconitase activity
  • citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
  • aconitase activity
Proteins in PDR annotated with:
   This term: 43 [Search]
   Term or descendants: 43 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003994 - aconitate hydratase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle