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Protein Overview: HTA2

General Information:
Name(s) found: HTA2 / YBL003C [SGD]
Description(s) found:
Found 37 descriptions.
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  • Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 132 amino acids

    Gene Ontology:
    Cellular Component: nuclear nucleosome [TASLink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    chromatin assembly or disassembly [TASLink to PubMed article]
    Molecular Function: DNA binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGGKGGKAG SAAKASQSRS AKAGLTFPVG RVHRLLRRGN YAQRIGSGAP VYLTAVLEYL  60
   61 AAEILELAGN AARDNKKTRI IPRHLQLAIR NDDELNKLLG NVTIAQGGVL PNIHQNLLPK 120
  121 KSAKTAKASQ EL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABF2 HHF1, HHF2 HTA2 HTB1 ISW1 ISW2 KAP114 MOT1 NAP1 RSC8
    View Details (MIPS) Mewes HW, et al. (2004) HHF1, HHF2 HHT1, HHT2 HTA1 HTA2 HTB1 HTB2
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Gavin AC, et al. (2002) ABF2 ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 CTI6 DBP8 DEP1 DIA4 DIM1 DIP2 DIS3 DOT6 EAF3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 IOC3 ISW1 KRE33 KRR1 LCP5 LTV1 MED4 MPP10 MRD1 MVD1 NAN1 NHP10 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 NRD1 PAP1 PFS2 PHO23 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 RCO1 REF2 RML2 RNA14 ROK1 RPD3 RPP2B RRP12 RRP7 RRP9 RSC8 RTG2 RXT2 RXT3 SAM1 SAP30 SCL1 SDS3 SEC21 SIN3 SLX9 SOF1 SRO9 STO1 TIF1, TIF2 TOP1 TSR1 TUP1 UME1 UME6 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YOR059C YSH1
    View Details Ho Y, et al. (2002) ADH4 ARC1 ASF1 CDC55 EDE1 ENP1 GAC1 GID8 GPG1 HEM15 HHF1, HHF2 HRP1 HTA1 HTA2 HTB1 HTB2 IPP1 KAP104 KNS1 KTR3 MAM33 MDH1 MKT1 NAB2 NDE1 NOB1 PAA1 POB3 PPE1 PPH22 PSH1 RAD53 RPA135 RPB11 RPT4 RTS1 RTS3 RVB1 SMC3 SPT16 SYP1 TAP42 TPD3 UTP22 YNL035C
    View Details Qiu et al. (2008) HHF1, HHF2 HHT1, HHT2 HTA1 HTA2 HTB1 HTB2 PCC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MAS2 No Comments Wong J, et all (2007)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CTF13 HTA2 1 Unpublished Fields Lab Data
    View Screen APC5 HTA2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HTA2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..59] PSI-BLAST 568.529817 Histone H2A
    2 View Details [60..132] PSI-BLAST 568.529817 Histone H2A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.581886805340955 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle