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Protein Overview: OLA1

General Information:
Name(s) found: OLA1 / YBR025C [SGD]
Description(s) found:
Found 37 descriptions.
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  • P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 394 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPKKQVEEK KVLLGRPGNN LKAGIVGLAN VGKSTFFQAI TRCPLGNPAN YPFATIDPEE  60
   61 ARVIVPSPRF DKLCEIYKKT ASEVPAHLTV YDIAGLTKGA SAGEGLGNAF LSHIRSVDSI 120
  121 YQVVRCFDDA EIIHVEGDVD PVRDLEIINQ ELRLKDIEFA QKALEGAEKI AKRGGQSLEV 180
  181 KQKKEEMDLI TKIIKLLESG QRVANHSWTS KEVEIINSMF LLTAKPCIYL INLSERDYIR 240
  241 KKNKHLLRIK EWVDKYSPGD LIIPFSVSLE ERLSHMSPED AEEELKKLQT ISALPKIITT 300
  301 MRQKLDLISF FTCGPDEVRE WTIRRGTKAP QAAGVIHNDL MNTFILAQVM KCEDVFEYKD 360
  361 DSAIKAAGKL MQKGKDYVVE DGDIIYFRAG AGKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATP2 GCN20 OLA1 SEC53
    View Details Krogan NJ, et al. (2006) ADH7 HCM1 OLA1 SNF8 VPS25 VPS36
    View Details Gavin AC, et al. (2006) OLA1 TEF4 YGL039W
    View Details Gavin AC, et al. (2002) CAM1 CMR1 CTF18 CTF8 DNA2 DPB2 EFB1 ELG1 FAP1 GFA1 GUS1 HDA1 HDA2 HDA3 HSC82 ILV1 KAP123 KAP95 LCD1 MEC1 MGA2 MGM101 MLH1 MPH1 MSH2 MSH3 MSH6 NEW1 OLA1 PGK1 PMS1 POL2 PRO2 RAD16 RAD52 RFA1 RFA2 RFA3 RFC1 RFC2 RFC3 RFC4 RFC5 RIM1 RNH1 RSC8 RVB2 SBP1 SEC27 SGS1 SHS1 TEF1, TEF2 TEF4 TIF1, TIF2 TOP2 TOP3 VAS1 VPS1 VPS13 YHR122W YMR181C
    View Details Ho Y, et al. (2002) AAT2 ACC1 ACH1 ACO1 ACS2 ADE3 ADE6 ADO1 AFR1 AHP1 ALA1 APE2 ARA1 ARC1 ARF1 ATP3 BAT1 CAR2 CDC10 CDC33 CLU1 COF1 COR1 CPR1 CPR6 CYR1 CYS3 CYS4 DED81 DPS1 EGD1 ERG10 ERG13 ERG20 ERG6 FAA4 FPR1 FRS2 GCY1 GND1 GND2 GPH1 GRS1 GRX1 GUS1 HEF3 HHF1, HHF2 HOM2 HYP2 ILS1 IMD3 KRS1 LIA1 LRO1 LSP1 MDH3 MET6 NTF2 OLA1 OYE2 PAB1 PFK1 PFK2 PGM2 PIL1 PMI40 PRM2 PRP6 RNR2 RPT4 RSN1 SAC6 SAH1 SCP160 SEC53 SEN15 SES1 SGD1 SNU13 SNU66 SOD1 SSZ1 TAF5 TEF4 THR4 THS1 TIF1, TIF2 TMA19 TRR1 TSA2 UBA1 UTP5 VMA4 VMA5 WTM1 YDL124W YER138C YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC53 OLA1 1 Unpublished Fields Lab Data
    View Screen RCY1 OLA1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OLA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] PSI-BLAST 38.522879 GTPase Era, N-terminal domain; GTPase Era C-terminal domain
    2 View Details [205..313] PSI-BLAST 38.522879 GTPase Era, N-terminal domain; GTPase Era C-terminal domain
    3 View Details [314..394] MSA 3.117992 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  3.21952132654519 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.06972174097431 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  2.99135301692379 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.81945030670779 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.81104198554628 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26558861202152 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.93408704555564 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.72121792847307 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • hydrolase activity
    		•  1.29060292615008 bayes_pls_golite062009
  • GTPase activity
    		•  1.23010905798386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.21658213854831 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.21652144153182 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.21571071905795 bayes_pls_golite062009
  • nucleotide binding
    		•  1.20347573865566 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.396187998943318 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • ATP binding
    		•  0.1860481660648 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.152859582615242 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.138615225841109 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.12351419478929 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle