YRC Public Data Repository - Protein Structure Prediction

Protein:	OLA1
Organism:	Saccharomyces cerevisiae
Length:	394 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OLA1.

Description	E-value	Query Range	Subject Range
gi\|14042261 - gi\|14042261\|dbj\|BAB55174.1\| unnamed protein product [Homo sapiens]	0.0	[1..393]	[1..391]
OLA1_MOUSE - Obg-like ATPase 1 OS=Mus musculus GN=Ola1 PE=1 SV=1	0.0	[1..393]	[1..391]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..393]	[1..391]
ENGD_PASMU - GTP-dependent nucleic acid-binding protein engD OS=Pasteurella multocida GN=engD PE=3 SV=3 YCHF_PASMU - Ribosome-binding ATPase YchF OS=Pasteurella multocida (strain Pm70) GN=ychF PE=3 SV=3	0.0	[19..391]	[1..363]
gi\|218431822, gi... - gi\|218704725\|ref\|YP_002412244.1\| GTP-dependent nucleic acid-binding protein EngD [Escherichia coli U... EG11404 - catalase inhibitor protein; ATPase, K+-dependent, ribosome-associated / Catalase inhibitor protein; ... YCHF_SHIFL - Ribosome-binding ATPase YchF OS=Shigella flexneri GN=ychF PE=3 SV=2 gi\|30062727, gi\|... - gi\|30062727\|ref\|NP_836898.1\| translation-associated GTPase [Shigella flexneri 2a str. 2457T], gi\|300... YCHF_ECO57 - Ribosome-binding ATPase YchF OS=Escherichia coli O157:H7 GN=ychF PE=3 SV=2 ENGD_ECOLI - GTP-dependent nucleic acid-binding protein engD - Escherichia coli gi\|24051506, gi\|... - gi\|24112602\|ref\|NP_707112.1\| translation-associated GTPase [Shigella flexneri 2a str. 301], gi\|24051... gi\|124500646, gi... - gi\|124528414\|ref\|ZP_01699724.1\| GTP-binding protein YchF [Escherichia coli B], gi\|124500646\|gb\|EAY48... gi\|75228263, gi\|... - gi\|75228263\|ref\|ZP_00714918.1\| COG0012: Predicted GTPase, probable translation factor [Escherichia c... gi\|75233900, gi\|... - gi\|75233900\|ref\|ZP_00718360.1\| COG0012: Predicted GTPase, probable translation factor [Escherichia c... EG11404 - catalase inhibitor protein; ATPase, K+-dependent, ribosome-associated / Catalase inhibitor protein; ... gi\|192925613, gi... - gi\|75255061\|ref\|ZP_00726966.1\| COG0012: Predicted GTPase, probable translation factor [Escherichia c... gi\|81240691, gi\|... - gi\|82776543\|ref\|YP_402892.1\| translation-associated GTPase [Shigella dysenteriae Sd197], gi\|81240691... gi\|81245754, gi\|... - gi\|82544343\|ref\|YP_408290.1\| translation-associated GTPase [Shigella boydii Sb227], gi\|81245754\|gb\|A... gi\|189356358, gi... - gi\|189356358\|gb\|EDU74777.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4401], gi\|1687... gi\|194436983, gi... - gi\|83587347\|ref\|ZP_00925975.1\| COG0012: Predicted GTPase, probable translation factor [Escherichia c... gi\|168750762, gi... - gi\|188015094\|gb\|EDU53216.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4113], gi\|1687... gi\|187730029, gi... - gi\|75179198\|ref\|ZP_00699216.1\| COG0012: Predicted GTPase, probable translation factor [Shigella boyd... gi\|189360083, gi... - gi\|189360083\|gb\|EDU78502.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4486], gi\|1687... gi\|157157840, gi... - gi\|75190257\|ref\|ZP_00703524.1\| COG0012: Predicted GTPase, probable translation factor [Escherichia c... gi\|168764411, gi... - gi\|189365599\|gb\|EDU84015.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4501], gi\|1687... gi\|75195356, gi\|... - gi\|75195356\|ref\|ZP_00705426.1\| COG0012: Predicted GTPase, probable translation factor [Escherichia c... gi\|168782557, gi... - gi\|189000062\|gb\|EDU69048.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4076], gi\|1687... gi\|75212641, gi\|... - gi\|75212641\|ref\|ZP_00712639.1\| COG0012: Predicted GTPase, probable translation factor [Escherichia c... gi\|168777787, gi... - gi\|187767045\|gb\|EDU30889.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4196], gi\|1687... gi\|4062787, gi\|8... - gi\|89108048\|ref\|AP_001828.1\| predicted GTP-binding protein [Escherichia coli str. K-12 substr. W3110... gi\|13361173, gi\|... - gi\|15830962\|ref\|NP_309735.1\| GTP-dependent nucleic acid-binding protein EngD [Escherichia coli O157:... gi\|110805208, gi... - gi\|110805208\|ref\|YP_688728.1\| translation-associated GTPase [Shigella flexneri 5 str. 8401], gi\|1106... gi\|208737744, gi... - gi\|208822259\|ref\|ZP_03262578.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4042], gi\|... gi\|208733066, gi... - gi\|208816418\|ref\|ZP_03257597.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4045], gi\|... gi\|209911703, gi... - gi\|209918444\|ref\|YP_002292528.1\| GTP-dependent nucleic acid-binding protein EngD [Escherichia coli S... gi\|209160238, gi... - gi\|209398838\|ref\|YP_002270137.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4115], gi... gi\|238900434, gi... - gi\|238900434\|ref\|YP_002926230.1\| putative GTP-binding protein [Escherichia coli BW2952], gi\|23886245... gi\|218553757, gi... - gi\|218553757\|ref\|YP_002386670.1\| GTP-dependent nucleic acid-binding protein EngD [Escherichia coli I... gi\|254592073, gi... - gi\|254792673\|ref\|YP_003077510.1\| predicted GTP-binding protein [Escherichia coli O157:H7 str. TW1435... gi\|217318721, gi... - gi\|217328294\|ref\|ZP_03444376.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. TW14588], gi... gi\|218699910, gi... - gi\|218699910\|ref\|YP_002407539.1\| GTP-dependent nucleic acid-binding protein EngD [Escherichia coli I... gi\|218694717, gi... - gi\|218694717\|ref\|YP_002402384.1\| GTP-dependent nucleic acid-binding protein EngD [Escherichia coli 5... gi\|189375870, gi... - gi\|189375870\|gb\|EDU94286.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC508], gi\|16880... gi\|189372434, gi... - gi\|189372434\|gb\|EDU90850.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC869], gi\|16878... gi\|169888666, gi... - gi\|170080831\|ref\|YP_001730151.1\| GTP-binding protein [Escherichia coli str. K-12 substr. DH10B], gi\|... gi\|169755358, gi... - gi\|170020430\|ref\|YP_001725384.1\| GTP-dependent nucleic acid-binding protein EngD [Escherichia coli A... gi\|194434920, gi... - gi\|194434920\|ref\|ZP_03067165.1\| GTP-binding protein EngD [Shigella dysenteriae 1012], gi\|194416853\|g... gi\|170518703, gi... - gi\|170680985\|ref\|YP_001743991.1\| GTP-binding protein EngD [Escherichia coli SMS-3-5], gi\|170518703\|g... gi\|208806944, gi... - gi\|208806944\|ref\|ZP_03249281.1\| GTP-binding protein EngD [Escherichia coli O157:H7 str. EC4206], gi\|... gi\|195938852 - gi\|195938852\|ref\|ZP_03084234.1\| translation-associated GTPase [Escherichia coli O157:H7 str. EC4024]	0.0	[19..391]	[1..363]
gi\|197937918, gi... - gi\|198243402\|ref\|YP_002215359.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serov... gi\|197241915, gi... - gi\|197263660\|ref\|ZP_03163734.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serova... gi\|204927806, gi... - gi\|204927806\|ref\|ZP_03219007.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serova... gi\|200391121, gi... - gi\|200391121\|ref\|ZP_03217732.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serova... gi\|194457767, gi... - gi\|194471403\|ref\|ZP_03077387.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serova... gi\|194448843, gi... - gi\|194448843\|ref\|YP_002045829.1\| GTP-dependent nucleic acid-binding protein EngD [Salmonella enteric... gi\|197251280, gi... - gi\|197251280\|ref\|YP_002146243.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serov... gi\|194737864, gi... - gi\|194737864\|ref\|YP_002114816.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serov... gi\|29137191, gi\|... - gi\|29141564\|ref\|NP_804906.1\| translation-associated GTPase [Salmonella enterica subsp. enterica sero... gi\|205350649, gi... - gi\|205350649\|gb\|EDZ37280.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serovar Ha... gi\|16760677 - gi\|16760677\|ref\|NP_456294.1\| translation-associated GTPase [Salmonella enterica subsp. enterica sero... gi\|168241370, gi... - gi\|205339463\|gb\|EDZ26227.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serovar He... gi\|25330229, gi\|... - gi\|25330229\|pir\|\|AB0721 probable ATP/GTP-binding protein STY1910 [imported] - Salmonella enterica su... gi\|194446679, gi... - gi\|194446679\|ref\|YP_002041036.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serov... gi\|16765125, gi\|... - gi\|16765125\|ref\|NP_460740.1\| translation-associated GTPase [Salmonella typhimurium LT2], gi\|16420314... gi\|205342710, gi... - gi\|205342710\|gb\|EDZ29474.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serovar We... gi\|161363081, gi... - gi\|161613717\|ref\|YP_001587682.1\| translation-associated GTPase [Salmonella enterica subsp. enterica ... gi\|205332111, gi... - gi\|205332111\|gb\|EDZ18875.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serovar Ke... gi\|167553610, gi... - gi\|205321986\|gb\|EDZ09825.1\| GTP-binding protein EngD [Salmonella enterica subsp. enterica serovar Sa... gi\|62127981, gi\|... - gi\|62180348\|ref\|YP_216765.1\| translation-associated GTPase [Salmonella enterica subsp. enterica sero... gi\|214002639 - gi\|214002639\|ref\|ZP_03413374.1\| translation-associated GTPase [Salmonella enterica subsp. enterica s... gi\|213850368 - gi\|213850368\|ref\|ZP_03381266.1\| translation-associated GTPase [Salmonella enterica subsp. enterica s... gi\|224468254, gi... - gi\|224583727\|ref\|YP_002637525.1\| putative ATP/GTP-binding protein [Salmonella enterica subsp. enteri... gi\|207856709, gi... - gi\|207856709\|ref\|YP_002243360.1\| GTP-dependent nucleic acid-binding protein EngD [Salmonella enteric... gi\|205272329, gi... - gi\|205352548\|ref\|YP_002226349.1\| GTP-dependent nucleic acid-binding protein EngD [Salmonella enteric... gi\|213650576 - gi\|213650576\|ref\|ZP_03380629.1\| translation-associated GTPase [Salmonella enterica subsp. enterica s... gi\|213426487 - gi\|213426487\|ref\|ZP_03359237.1\| translation-associated GTPase [Salmonella enterica subsp. enterica s... gi\|238913685 - gi\|238913685\|ref\|ZP_04657522.1\| translation-associated GTPase [Salmonella enterica subsp. enterica s...	0.0	[19..391]	[1..363]
ENGD_HAEIN - GTP-dependent nucleic acid-binding protein engD OS=Haemophilus influenzae GN=engD PE=1 SV=2 YCHF_HAEIN - Ribosome-binding ATPase YchF OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) G...	0.0	[19..391]	[1..363]
OLA1_YEAST - Obg-like ATPase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OLA1 PE=1 SV=1 gi\|151946418 - gi\|151946418\|gb\|EDN64640.1\| obg-like ATPase [Saccharomyces cerevisiae YJM789] OLA1 - P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacti... gi\|190408806 - gi\|190408806\|gb\|EDV12071.1\| hypothetical protein SCRG_02939 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..394]	[1..394]

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Predicted Domain #1

Region A:
Residues: [1-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPKKQVEEK KVLLGRPGNN LKAGIVGLAN VGKSTFFQAI TRCPLGNPAN YPFATIDPEE  60
   61 ARVIVPSPRF DKLCEIYKKT ASEVPAHLTV YDIAGLTKGA SAGEGLGNAF LSHIRSVDSI 120
  121 YQVVRCFDDA EIIHVEGDVD PVRDLEIINQ ELRLKDIEFA QKALEGAEKI AKRGGQSLEV 180
  181 KQKKEEMDLI TKIIKLLESG QRVA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.522879
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrogen ion transmembrane transporter activity	3.21952132654519	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.06972174097431	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	2.99135301692379	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.81945030670779	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.81104198554628	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
substrate-specific transporter activity	2.26558861202152	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
ion transmembrane transporter activity	1.93408704555564	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
cation transmembrane transporter activity	1.72121792847307	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
hydrolase activity	1.29060292615008	bayes_pls_golite062009
GTPase activity	1.23010905798386	bayes_pls_golite062009
purine ribonucleotide binding	1.21658213854831	bayes_pls_golite062009
ribonucleotide binding	1.21652144153182	bayes_pls_golite062009
purine nucleotide binding	1.21571071905795	bayes_pls_golite062009
nucleotide binding	1.20347573865566	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
structural constituent of ribosome	0.396187998943318	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
ATP binding	0.1860481660648	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
adenyl ribonucleotide binding	0.152859582615242	bayes_pls_golite062009
adenyl nucleotide binding	0.138615225841109	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.12351419478929	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [205-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHSWTSKEVE IINSMFLLTA KPCIYLINLS ERDYIRKKNK HLLRIKEWVD KYSPGDLIIP  60
   61 FSVSLEERLS HMSPEDAEEE LKKLQTISAL PKIITTMRQK LDLISFFTC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.522879
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [314-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPDEVREWTI RRGTKAPQAA GVIHNDLMNT FILAQVMKCE DVFEYKDDSA IKAAGKLMQK  60
   61 GKDYVVEDGD IIYFRAGAGK N

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.825	0.846	cytoplasm	c.47.1	Thioredoxin-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: