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Protein Overview: ADH7

General Information:
Name(s) found: ADH7 / YCR105W [SGD]
Description(s) found:
Found 24 descriptions.
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  • NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 361 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    Biological Process: alcohol metabolic process [IDALink to PubMed article]
    Molecular Function: alcohol dehydrogenase (NADP+) activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYPEKFQGI GISNAKDWKH PKLVSFDPKP FGDHDVDVEI EACGICGSDF HIAVGNWGPV  60
   61 PENQILGHEI IGRVVKVGSK CHTGVKIGDR VGVGAQALAC FECERCKSDN EQYCTNDHVL 120
  121 TMWTPYKDGY ISQGGFASHV RLHEHFAIQI PENIPSPLAA PLLCGGITVF SPLLRNGCGP 180
  181 GKRVGIVGIG GIGHMGILLA KAMGAEVYAF SRGHSKREDS MKLGADHYIA MLEDKGWTEQ 240
  241 YSNALDLLVV CSSSLSKVNF DSIVKIMKIG GSIVSIAAPE VNEKLVLKPL GLMGVSISSS 300
  301 AIGSRKEIEQ LLKLVSEKNV KIWVEKLPIS EEGVSHAFTR MESGDVKYRF TLVDYDKKFH 360
  361 K

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADH7 HCM1 OLA1 SNF8 VPS25 VPS36

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166]
    [304..361]    		 PSI-BLAST 217.9897 Alcohol dehydrogenase
    2 View Details [167..303] PSI-BLAST 217.9897 Alcohol dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ethanol binding
    		•  3.52197234018599 bayes_pls_golite062009
  • NAD or NADH binding
    		•  3.39892156245282 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • methylglyoxal reductase (NADH-dependent) activity
    		•  3.00190838171391 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.94416173750168 bayes_pls_golite062009
  • retinol binding
    		•  2.90377414635828 bayes_pls_golite062009
  • hydroxymethylfurfural reductase (NADH) activity
    		•  2.2999175117758 bayes_pls_golite062009
  • hydroxymethylfurfural reductase activity
    		•  2.2999175117758 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  2.26153457113968 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  2.16668841986245 bayes_pls_golite062009
  • alcohol binding
    		•  2.01620480773869 bayes_pls_golite062009
  • all-trans retinal binding
    		•  1.96535395605564 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  1.81250968237368 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • DNA binding
    		•  1.61355789916908 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.55390653047158 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48478425318425 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.22444609393125 bayes_pls_golite062009
  • chaperone binding
    		•  1.19079350615542 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91090893050278 bayes_pls_golite062009
  • structural molecule activity
    		•  0.75267483298133 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.621273823467575 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.523513694229008 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.44080203587472 bayes_pls_golite062009
  • hydroxymethylfurfural reductase (NADPH) activity
    		•  0.382131941157781 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.216422278300306 bayes_pls_golite062009
  • methylenetetrahydrofolate dehydrogenase activity
    		•  0.169301675015808 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  0.162625185692811 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.0992243118937675 bayes_pls_golite062009
  • retinal binding
    		•  0.00342169427806049 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.43

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle