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Protein Overview: HCM1

General Information:
Name(s) found: HCM1 / YCR065W [SGD]
Description(s) found:
Found 19 descriptions.
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  • Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 564 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: spindle pole body organization [IGILink to PubMed article]
    regulation of transcription involved in G1/S-phase of mitotic cell cycle [IPILink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    regulation of transcription involved in S-phase of mitotic cell cycle [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article][ISSLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article][IMPLink to PubMed article]
    specific RNA polymerase II transcription factor activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNEDISIID GHNSFLTEKS TVLLTQAKRT LEDEKEMITP PSSTVRKTMK EVNKRPSHPL  60
   61 SPDHSSPIAP SKAKRQRSDT CARSNGNLTL EEILQSLERR RINGELAKKP PYSYATLICL 120
  121 AILQSQEGKL TLSQIYHWIH VHFPYYKQKD ASWQNSIRHN LSLNDAFIKT EKSCDGKGHF 180
  181 WEVRPGAETK FFKGENRGYE FVKDSLQDIG KYFEIDSTLD ELEQVESGEG NDDLPDEEER 240
  241 EEAGKFPSIE IQLNSSPILR VSQLHHIPQL KTDNSVLNPH ENLESMRNMI ENDVNNIDSL 300
  301 EPPYVMKKYH TSLGLPSLVN AKDHFQAGVK NNNITQANRF NTLPITSAKS PQNFRKYFTS 360
  361 FNSNFEDLSP LRSNVGAGSL LDPLPYSPLK LYDQKNLALM SKPQSQQSYS NSQLPPPPSS 420
  421 HGSDLLKTPK MRHSDGLEKT PSRLISTPKD GNSILRKWQT PSHLFEDLYC SPLFRAIETP 480
  481 IRYITTPGGT LETQISPRKS SAPDVLTSAT NSKFASSGLF GVDVYSVWKR ATEKISDGNN 540
  541 TTDSNQKHHP YHNHPSNDSG NEKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADH7 HCM1 OLA1 SNF8 VPS25 VPS36

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HCM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] deduced N/A No confident structure predictions are available.
    2 View Details [103..204] PSI-BLAST 41.221849 Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
    3 View Details [205..436] MSA 7.445997 View MSA. No confident structure predictions are available.
    4 View Details [437..564] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle