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Protein Overview: VPS36

General Information:
Name(s) found: VPS36 / YLR417W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 566 amino acids

    Gene Ontology:
    Cellular Component: ESCRT II complex [IDALink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ICLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    negative regulation of transcription from RNA polymerase II promoter by glucose [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: regulator of G-protein signaling activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYWHYVETT SSGQPLLREG EKDIFIDQSV GLYHGKSKIL QRQRGRIFLT SQRIIYIDDA  60
   61 KPTQNSLGLE LDDLAYVNYS SGFLTRSPRL ILFFKDPSSK DELGKSAETA SADVVSTWVC 120
  121 PICMVSNETQ GEFTKDTLPT PICINCGVPA DYELTKSSIN CSNAIDPNAN PQNQFGVNSE 180
  181 NICPACTFAN HPQIGNCEIC GHRLPNASKV RSKLNRLNFH DSRVHIELEK NSLARNKSSH 240
  241 SALSSSSSTG SSTEFVQLSF RKSDGVLFSQ ATERALENIL TEKNKHIFNQ NVVSVNGVDM 300
  301 RKGASSHEYN NEVPFIETKL SRIGISSLEK SRENQLLNND ILFNNALTDL NKLMSLATSI 360
  361 ERLYKNSNIT MKTKTLNLQD ESTVNEPKTR RPLLILDREK FLNKELFLDE IAREIYEFTL 420
  421 SEFKDLNSDT NYMIITLVDL YAMYNKSMRI GTGLISPMEM REACERFEHL GLNELKLVKV 480
  481 NKRILCVTSE KFDVVKEKLV DLIGDNPGSD LLRLTQILSS NNSKSNWTLG ILMEVLQNCV 540
  541 DEGDLLIDKQ LSGIYYYKNS YWPSHI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SNF8 VPS36
    View Details Krogan NJ, et al. (2006) ADH7 HCM1 OLA1 SNF8 VPS25 VPS36
    View Details Qiu et al. (2008) DID4 SNF8 VPS20 VPS25 VPS36

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SST2 VPS36 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS36 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] deduced N/A No confident structure predictions are available.
    2 View Details [148..566] MSA 3.010891 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.95502209146398 bayes_pls_golite062009
  • DNA binding
    		•  4.49877554292304 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.4138116788102 bayes_pls_golite062009
  • transcription factor activity
    		•  3.78905634607011 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.35896772348591 bayes_pls_golite062009
  • binding
    		•  3.09940998297931 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.10135825467854 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.97423148823534 bayes_pls_golite062009
  • transcription activator activity
    		•  1.86787909680028 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.574575108509588 bayes_pls_golite062009
  • signal transducer activity
    		•  0.574575108509588 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.51900654743421 bayes_pls_golite062009
  • transcription factor binding
    		•  0.35726633913804 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.18158516638045 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.118016217031359 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0384502189988831 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle