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View Structure Prediction Details

Protein: ADH7
Organism: Saccharomyces cerevisiae
Length: 361 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADH7.

Description E-value Query
Range		 Subject
Range
gi|6684357 - gi|6684357|gb|AAF23539.1|AF110441_1 alcohol dehydrogenase [Halimolobos perplexa var. lemhiensis]
 0.0 [5..354] [8..377]
ADHX_SPAAU - Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1
 0.0 [5..353] [8..375]
gi|2570190 - gi|2570190|dbj|BAA22979.1| alcohol dehydrogenase [Arabidopsis thaliana]
 0.0 [5..354] [8..377]
gi|6684354 - gi|6684354|gb|AAF23536.1|AF110438_1 alcohol dehydrogenase [Arabis fendleri]
 0.0 [5..354] [8..377]
gi|6684364 - gi|6684364|gb|AAF23546.1|AF110448_1 alcohol dehydrogenase [Arabis lyallii]
 0.0 [5..354] [8..377]
gi|2570182, gi|2... - gi|2570182|dbj|BAA22976.1| alcohol dehydrogenase [Arabidopsis halleri subsp. gemmifera], gi|2570176|...
 0.0 [5..354] [8..377]
gi|6684358 - gi|6684358|gb|AAF23540.1|AF110442_1 alcohol dehydrogenase [Arabidopsis halleri]
 0.0 [5..354] [8..377]
gi|6684350 - gi|6684350|gb|AAF23532.1|AF110434_1 alcohol dehydrogenase [Brassica oleracea]
 0.0 [5..354] [8..377]

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Predicted Domain #1
Region A:
Residues: [1-166] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYPEKFQGI GISNAKDWKH PKLVSFDPKP FGDHDVDVEI EACGICGSDF HIAVGNWGPV  60
   61 PENQILGHEI IGRVVKVGSK CHTGVKIGDR VGVGAQALAC FECERCKSDN EQYCTNDHVL 120
  121 TMWTPYKDGY ISQGGFASHV RLHEHFAIQI PENIPSPLAA PLLCGG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [304-361] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRKEIEQLLK LVSEKNVKIW VEKLPISEEG VSHAFTRMES GDVKYRFTLV DYDKKFHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 217.9897
Match: 1hdzA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ethanol binding 3.52197234018599 bayes_pls_golite062009
NAD or NADH binding 3.39892156245282 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
methylglyoxal reductase (NADH-dependent) activity 3.00190838171391 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 2.94416173750168 bayes_pls_golite062009
retinol binding 2.90377414635828 bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity 2.2999175117758 bayes_pls_golite062009
hydroxymethylfurfural reductase activity 2.2999175117758 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 2.26153457113968 bayes_pls_golite062009
NADPH:quinone reductase activity 2.16668841986245 bayes_pls_golite062009
alcohol binding 2.01620480773869 bayes_pls_golite062009
all-trans retinal binding 1.96535395605564 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 1.81250968237368 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
DNA binding 1.61355789916908 bayes_pls_golite062009
transcription regulator activity 1.55390653047158 bayes_pls_golite062009
nucleic acid binding 1.48478425318425 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.22444609393125 bayes_pls_golite062009
chaperone binding 1.19079350615542 bayes_pls_golite062009
retinol dehydrogenase activity 1.16811519855038 bayes_pls_golite062009
binding 0.982999356179965 bayes_pls_golite062009
transcription factor activity 0.91090893050278 bayes_pls_golite062009
structural molecule activity 0.75267483298133 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.621273823467575 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.523513694229008 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 0.44080203587472 bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity 0.382131941157781 bayes_pls_golite062009
coenzyme binding 0.35922330382799 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.216422278300306 bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity 0.169301675015808 bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity 0.162625185692811 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.0992243118937675 bayes_pls_golite062009
retinal binding 0.00342169427806049 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [167-303] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITVFSPLLRN GCGPGKRVGI VGIGGIGHMG ILLAKAMGAE VYAFSRGHSK REDSMKLGAD  60
   61 HYIAMLEDKG WTEQYSNALD LLVVCSSSLS KVNFDSIVKI MKIGGSIVSI AAPEVNEKLV 120
  121 LKPLGLMGVS ISSSAIG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 217.9897
Match: 1hdzA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle