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Protein Overview: HAS1

General Information:
Name(s) found: HAS1 / YMR290C [SGD]
Description(s) found:
Found 28 descriptions.
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  • ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    nucleolus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]
    RNA-dependent ATPase activity [IDALink to PubMed article]
    ATP-dependent RNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATPSNKRSR DSESTEEPVV DEKSTSKQNN AAPEGEQTTC VEKFEELKLS QPTLKAIEKM  60
   61 GFTTMTSVQA RTIPPLLAGR DVLGAAKTGS GKTLAFLIPA IELLHSLKFK PRNGTGIIVI 120
  121 TPTRELALQI FGVARELMEF HSQTFGIVIG GANRRQEAEK LMKGVNMLIA TPGRLLDHLQ 180
  181 NTKGFVFKNL KALIIDEADR ILEIGFEDEM RQIIKILPNE DRQSMLFSAT QTTKVEDLAR 240
  241 ISLRPGPLFI NVVPETDNST ADGLEQGYVV CDSDKRFLLL FSFLKRNQKK KIIVFLSSCN 300
  301 SVKYYAELLN YIDLPVLELH GKQKQQKRTN TFFEFCNAER GILICTDVAA RGLDIPAVDW 360
  361 IIQFDPPDDP RDYIHRVGRT ARGTKGKGKS LMFLTPNELG FLRYLKASKV PLNEYEFPEN 420
  421 KIANVQSQLE KLIKSNYYLH QTAKDGYRSY LQAYASHSLK TVYQIDKLDL AKVAKSYGFP 480
  481 VPPKVNITIG ASGKTPNTKR RKTHK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BRX1 CBF5 CIC1 DBP10 DBP9 DRS1 ERB1 FPR4 HAS1 LOC1 MAK21 MAK5 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPF2 RPL11B RPL15A RPL1A, RPL1B RPL25 RPL27A RRP1 RRP12 SDA1 SPB1 SPB4 TIF6 URB1 UTP10 UTP20 YTM1
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2002) AAR2 ADE4 ARO1 ARX1 BEM2 BFR2 BMS1 BRX1 BUD20 BUD21 CBF5 CFT2 CIC1 CLU1 CYR1 CYS4 DBP10 DBP8 DBP9 DCP2 DIP2 DRS1 EBP2 ECM16 ECM29 EMG1 EMP24 ENP1 ENP2 ERB1 ERO1 ERP1 ERP2 ERV25 ESF1 ESF2 FIP1 FKS1 FPR4 FUN12 GAR1 GCN1 GLC7 HAS1 HCA4 HDA1 HER1 HHF1, HHF2 HIS3 HSL1 HTA2 IMP3 IMP4 INP2 IPI1 IPI3 KAP123 KRE33 KRR1 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MPP10 MRP7 MRT4 MVD1 NAN1 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PAP1 PFS2 PHB1 POL2 PRE6 PRE9 PRP4 PRP43 PRT1 PTA1 PTI1 PUF6 PWP2 REF2 REI1 RIX1 RIX7 RLP24 RLP7 RML2 RNA14 ROK1 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RRP9 RSA3 RSA4 RTG2 RTR1 SCL1 SDA1 SEC21 SEC7 SKI2 SMB1 SNU114 SNU13 SNU66 SOF1 SPB1 SPB4 SRO9 SSF1 TIF1, TIF2 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YGL036W YMR310C YSH1 YTM1
    View Details Ho Y, et al. (2002) ACO1 AIM46 ARE1 ARP7 BFA1 CBF5 CBP2 CCM1 CCT6 CDC14 CDC33 CIC1 CKA1 CKA2 CKB1 CKB2 COR1 DBP10 DBP2 DBP7 DIG1 DIG2 DIS3 DOG1 EAF3 EGD1 EGD2 ENP1 ENP2 ERB1 FET4 FIP1 FPR3 FUN12 GBP2 GFA1 GND1 GRS1 GUS1 HAS1 HHT1, HHT2 HMO1 HOT1 HPR1 HTA1 HTB2 HXT6 HXT7 IMD1 IMD2 IMD3 IMD4 ISA1 KAP95 KRE33 KRI1 KSS1 MAG2 MAM33 MES1 MET6 MFT1 MGM101 MKT1 MRT4 MSC3 MSE1 MSS116 MUB1 NAM8 NAP1 NOC2 NOC3 NOG1 NOP1 NOP12 NOP2 NOP4 NOP56 NOP6 NOP7 NPL3 NSA1 NUG1 NUP1 NUP2 NUP60 OYE2 PAP1 PCT1 PDC6 PDI1 PET127 PHO84 PIM1 PMA1 POB3 POL5 PRP43 PRP8 PUF6 PWP1 PYC1 QCR2 REB1 RGC1 RLI1 RNT1 RPA135 RPF2 RPN10 RRP1 RRP12 RRP15 RRP4 RRP43 RRP5 RRP6 RTT103 RVB1 SAH1 SAP185 SAP190 SCS2 SEC53 SEN1 SIF2 SIN3 SIT4 SNP1 SNU56 SPB1 SPB4 SPT16 SRP1 SSF1 SSQ1 STE12 STE7 STO1 TEC1 TEM1 THO2 TIF4631 TIF4632 TIF6 TRA1 TSR1 UBI4 UBR2 UME1 URB1 URB2 UTP10 UTP20 UTP22 VAC14 YDR239C YER084W YHR033W YPP1 YPR090W YRA1 YTM1
    View Details Qiu et al. (2008) DBP10 DBP3 DBP6 DBP7 DHR2 DRS1 GAR1 HAS1 IFH1 MAK5 MRD1 MTR4 NOP4 PRP43 ROK1 RRP3 UTP11 UTP6 UTP7 UTP8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..259] PSI-BLAST 549.218487 Putative DEAD box RNA helicase
    2 View Details [260..410] PSI-BLAST 549.218487 Putative DEAD box RNA helicase
    3 View Details [411..505] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle