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Protein Overview: SNP1

General Information:
Name(s) found: SNP1 / YIL061C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 300 amino acids

    Gene Ontology:
    Cellular Component: commitment complex [IPILink to PubMed article]
    U1 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: U1 snRNA binding [IPILink to PubMed article]
    mRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYNLSKYPD DVSRLFKPRP PLSYKRPTDY PYAKRQTNPN ITGVANLLST SLKHYMEEFP  60
   61 EGSPNNHLQR YEDIKLSKIK NAQLLDRRLQ NWNPNVDPHI KDTDPYRTIF IGRLPYDLDE 120
  121 IELQKYFVKF GEIEKIRIVK DKITQKSKGY AFIVFKDPIS SKMAFKEIGV HRGIQIKDRI 180
  181 CIVDIERGRT VKYFKPRRLG GGLGGRGYSN RDSRLPGRFA SASTSNPAER NYAPRLPRRE 240
  241 TSSSAYSADR YGSSTLDARY RGNRPLLSAA TPTAAVTSVY KSRNSRTRES QPAPKEAPDY 300
  301

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR1 BRR2 CBC2 LUC7 MUD1 NAM8 PRP11 PRP39 PRP4 PRP40 PRP42 PRP8 RSE1 SMB1 SMD1 SMD2 SMD3 SME1 SMX3 SNP1 SNU114 SNU56 SNU71 STO1 YHC1
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2006) LUC7 MUD1 NAM8 PRP39 PRP40 PRP42 SNP1 SNU56 SNU71 YHC1
    View Details Gavin AC, et al. (2002) AAR2 AIR2 ASC1 BRR1 BUD31 BUR2 CBC2 CBF5 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DBP2 DHH1 DIB1 ECM2 GCN2 HEK2 HHF1, HHF2 HRT1 HSH155 HSH49 HTA1 IMG1 KAP95 LEA1 LHP1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MIS1 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSH4 MSL1 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PAT1 POL2 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 PUS7 RBG1 ROM2 RSE1 RVB2 SBP1 SCP160 SEN1 SGV1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 SRO9 SRP1 STM1 STO1 SUI3 SYF1 THO2 TIF1, TIF2 TIF4631 TIF4632 TOS4 UTP20 UTP21 YEF3 YML6 YMR310C YRA2
    View Details Ho Y, et al. (2002) BCY1 COR1 DOG1 ENP1 FET4 FPR3 HAS1 MAM33 PIM1 PRP8 QCR2 SAP185 SAP190 SIT4 SNP1 SRP1 VAC14
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 CWC25 DHR2 DIB1 HSH155 HSH49 IST3 ISY1 LEA1 LSM3 LSM4 LSM5 LSM7 LSM8 LUC7 MAK5 MSL1 MSL5 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #27 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps3-5 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SNP1 KIN3 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SNP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] PSI-BLAST 99.9691 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    2 View Details [91..187] PSI-BLAST 99.9691 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    3 View Details [188..300] PSI-BLAST 80.30103 Hu antigen D (Hud)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • U1 snRNA binding
    		•  4.22094068431436 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • protein binding
    		•  0.872515134876947 bayes_pls_golite062009
  • ligase activity
    		•  0.633198446266208 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle