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Protein Overview: TIF4631

General Information:
Name(s) found: TIF4631 / YGR162W [SGD]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 952 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 4F complex [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    ribosome [TASLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    translational initiation [TASLink to PubMed article]
    Molecular Function: translation initiation factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDETAHPTQ SASKQESAAL KQTGDDQQES QQQRGYTNYN NGSNYTQKKP YNSNRPHQQR  60
   61 GGKFGPNRYN NRGNYNGGGS FRGGHMGANS SNVPWTGYYN NYPVYYQPQQ MAAAGSAPAN 120
  121 PIPVEEKSPV PTKIEITTKS GEHLDLKEQH KAKLQSQERS TVSPQPESKL KETSDSTSTS 180
  181 TPTPTPSTND SKASSEENIS EAEKTRRNFI EQVKLRKAAL EKKRKEQLEG SSGNNNIPMK 240
  241 TTPENVEEKG SDKPEVTEKT KPAEEKSAEP EVKQETPAEE GEQGEKGQIK EESTPKVLTF 300
  301 AERLKLKKQQ KEREEKTEGK ENKEVPVQEE TKSAIESAPV PPSEQVKEET EVAETEQSNI 360
  361 DESATTPAIP TKSDEAEAEV EAEAGDAGTK IGLEAEIETT TDETDDGTNT VSHILNVLKD 420
  421 ATPIEDVFSF NYPEGIEGPD IKYKKEHVKY TYGPTFLLQF KDKLNVKADA EWVQSTASKI 480
  481 VIPPGMGRGN RSRDSGRFGN NSSRGHDFRN TSVRNMDDRA NSRTSSKRRS KRMNDDRRSN 540
  541 RSYTSRRDRE RGSYRNEEKR EDDKPKEEVA PLVPSANRWV PKFKSKKTEK KLAPDGKTEL 600
  601 LDKDEVERKM KSLLNKLTLE MFDAISSEIL AIANISVWET NGETLKAVIE QIFLKACDEP 660
  661 HWSSMYAQLC GKVVKELNPD ITDETNEGKT GPKLVLHYLV ARCHAEFDKG WTDKLPTNED 720
  721 GTPLEPEMMS EEYYAAASAK RRGLGLVRFI GFLYRLNLLT GKMMFECFRR LMKDLTDSPS 780
  781 EETLESVVEL LNTVGEQFET DSFRTGQATL EGSQLLDSLF GILDNIIQTA KISSRIKFKL 840
  841 IDIKELRHDK NWNSDKKDNG PKTIQQIHEE EERQRQLKNN SRSNSRRTNN SSNRHSFRRD 900
  901 APPASKDSFI TTRTYSQRNS QRAPPPKEEP AAPTSTATNM FSALMGESDD EE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CBF5 CDC33 KEM1 LHP1 MSS116 POL2 RSE1 SGN1 STO1 TIF1, TIF2 TIF4631 TIF4632
    View Details (MIPS) Mewes HW, et al. (2004) CAF20 CDC33 PAB1 TIF4631 TIF4632
    View Details Krogan NJ, et al. (2006) CAF20 CDC33 EAP1 PSP2 SLF1 TIF1, TIF2 TIF4631 TIF4632 YOR287C
    View Details Gavin AC, et al. (2006) CDC33 RBG1 SBP1 TIF4631 TIF4632
    View Details Gavin AC, et al. (2002) AAR2 AIR2 AMN1 ASC1 BEM2 BRR1 BRX1 BUD14 BUR2 CBC2 CBF5 CCM1 CDC33 CIC1 CLF1 CSN12 CUS1 CWC2 DBP2 DBP9 DIB1 DRS1 ECM16 ECM2 EHD3 ERB1 FUN12 FYV4 GAR1 GEP3 HAS1 HCA4 HEK2 HHF1, HHF2 HSC82 HSH155 HTA1 IML1 KAP95 KIN3 KRE33 KRR1 LEA1 LHP1 LSM4 LUC7 MAK21 MDN1 MIS1 MRP1 MRP10 MRP13 MRP17 MRP21 MRP4 MRP51 MRP7 MRPS16 MRPS17 MRPS18 MRPS28 MRPS5 MRPS8 MRPS9 MSH4 MSL1 MUD1 NAB3 NAB6 NAM7 NAM8 NAM9 NHP2 NIP1 NOC2 NOG1 NOP1 NOP12 NOP2 NOP4 NOP56 NOP6 NOP7 NPL3 NRD1 NRP1 NUG1 NUP60 PAP2 PET123 POL2 PRP11 PRP19 PRP21 PRP3 PRP31 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP9 PSD2 PUB1 PUF6 PUS7 RBG1 RIX1 RLP7 ROM2 RRP12 RSE1 RSM10 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 SBP1 SCP160 SEN1 SGN1 SGV1 SKI3 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNF2 SNP1 SNT309 SNU114 SNU56 SNU66 SNU71 SPP382 SRB2 SRO9 SRP1 SRV2 SSZ1 STM1 STO1 SUI3 SWI1 TDH3 THO2 TIF1, TIF2 TIF4631 TIF4632 UBP10 URB1 UTP10 UTP20 UTP21 UTP22 YEF3 YGR250C YMR310C YRA2 YTM1 ZUO1
    View Details Ho Y, et al. (2002) AAC3 ADK1 AI1 AIM46 ARE1 BRX1 BUD3 CBF5 CBP2 CCM1 CCT2 CCT3 CCT6 CDC10 CDC11 CDC12 CDC3 CDC33 CIC1 CIN8 CKA1 CKA2 CKB1 CKB2 CLU1 COP1 CYS4 DBP10 DBP7 DPB11 DRS1 EBP2 ENP2 ERB1 FAL1 FET4 FUN12 GBP2 GCD1 GCD11 GCD2 GCD6 GCN3 GDE1 GND1 GPH1 GRS1 GSP1 HAS1 HHF1, HHF2 HHO1 HIR1 HMO1 HOT1 HTB1 HTB2 IMD1 IMD2 IMD3 IMD4 ISA1 KAP95 KRE33 KRI1 KRR1 MAG1 MAG2 MGM101 MNP1 MPH1 MRPL1 MSC3 MSH2 MSS116 NAN1 NMD3 NOC2 NOC3 NOP12 NOP13 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NPL3 NUG1 OYE2 PDC6 PDI1 PET127 POB3 POL2 POL5 PRP11 PRP43 PUB1 PUF6 PWP1 RET1 REX2 RLI1 RPC82 RPF2 RRP12 RRP14 RRP5 RVB1 SEC27 SFP1 SGN1 SHM2 SPT16 SPT2 SRP1 SSD1 SSF1 SSK2 STE23 SUI2 SUI3 SUP45 TFP1 THI22 TIF1, TIF2 TIF4631 TIF4632 TIF6 TMA19 TRA1 TRL1 TSR1 UBP15 URB1 URB2 UTP10 UTP13 UTP20 UTP22 UTP7 VMR1 VPS73 WTM2 YGR250C YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) CDC33 TIF1, TIF2 TIF3 TIF4631 TIF4632

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ALG13 No Comments Hazbun TR, et al. (2003)
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TIF4631 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] ORFEUS 12.14 No description for 1l8mA was found.
    2 View Details [83..402] ORFEUS 10.91 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    3 View Details [403..505] ORFEUS 10.91 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    4 View Details [506..591] deduced N/A No confident structure predictions are available.
    5 View Details [592..731] PSI-BLAST 310.165202 Eukaryotic initiation factor eIF4G
    6 View Details [732..890] PSI-BLAST 310.165202 Eukaryotic initiation factor eIF4G
    7 View Details [891..952] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • translation initiation factor activity
    		•  10.603094323259 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  6.05435928492991 bayes_pls_golite062009
  • translation regulator activity
    		•  6.02151774494908 bayes_pls_golite062009
  • binding
    		•  1.66056773797288 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33292024661028 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • translation initiation factor activity
    		•  9.72578576774139 bayes_pls_golite062009
  • RNA cap binding
    		•  6.12623630895688 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  5.51508149717622 bayes_pls_golite062009
  • translation regulator activity
    		•  5.47755138510933 bayes_pls_golite062009
  • structural molecule activity
    		•  4.37969512292045 bayes_pls_golite062009
  • binding
    		•  2.48958374349477 bayes_pls_golite062009
  • RNA binding
    		•  1.98024495780436 bayes_pls_golite062009
  • protein binding
    		•  1.94427330399472 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.14394632253646 bayes_pls_golite062009
  • signal sequence binding
    		•  0.289133192719901 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.232758919136574 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.223441052840823 bayes_pls_golite062009
  • DNA binding
    		•  0.206335065849379 bayes_pls_golite062009
  • mRNA binding
    		•  0.12130984199507 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle