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Protein Overview: CBC2

General Information:
Name(s) found: CBC2 / YPL178W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 208 amino acids

    Gene Ontology:
    Cellular Component: commitment complex [IDALink to PubMed article]
    nuclear cap binding complex [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    nuclear mRNA splicing, via spliceosome [IMPLink to PubMed article]
    Molecular Function: RNA cap binding [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEEFDEVK YDHSTKRLDT PSRYLLRKAR RNPNGLQELR ESMKSSTIYV GNLSFYTSEE  60
   61 QIYELFSKCG TIKRIIMGLD RFKFTPCGFC FIIYSCPDEA LNALKYLSDT KLDEKTITID 120
  121 LDPGFEDGRQ FGRGKSGGQV SDELRFDFDA SRGGFAIPFA ERVGVPHSRF DNSSSQSNTN 180
  181 NYIPPPDAMG TFRPGFDEER EDDNYVPQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CBC2 KAP95 LUC7 MUD1 NAB3 NAM8 NPL3 NRD1 PRP39 PRP40 PRP42 SMD2 SNP1 SNU56 SNU71 SRP1 STO1 TIF4632 YRA2
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) CBC2 KAP95 NUP1 NUP2 NUP60 OGG1 PCT1 RAD53 SRP1 STO1 ULP1 URB2 YRA2
    View Details Gavin AC, et al. (2002) AIR2 BRR1 BUR2 CBC2 CDC33 CLF1 CSN12 CUS1 CWC2 DIB1 ECM2 HSH155 HTA1 KAP95 LEA1 LSM4 LUC7 MSH4 MSL1 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PRP11 PRP19 PRP21 PRP3 PRP31 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP9 RSE1 SCP160 SEN1 SGV1 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU56 SNU66 SNU71 SPP382 SRB2 SRO9 SRP1 STO1 THO2 TIF4631 TIF4632 YEF3 YRA2
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CDC5 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 HSH155 HSH49 ISY1 LEA1 LSM1 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MAK5 MSL1 MSL5 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CBC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..208] PSI-BLAST 391.156545 CBP20, 20KDa nuclear cap-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • RNA cap binding
    		•  5.43390507836051 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • snRNA binding
    		•  3.28448936696877 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.26303528058407 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • protein binding
    		•  1.14508556628804 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle