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Protein Overview: TIF4632

General Information:
Name(s) found: TIF4632 / YGL049C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 914 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 4F complex [IGILink to PubMed article][ISSLink to PubMed article]
    ribosome [TASLink to PubMed article]
    Biological Process: translational initiation [TASLink to PubMed article]
    Molecular Function: translation initiation factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDQRGPPPP HPQQANGYKK FPPHDNQYSG ANNSQPNNHY NENLYSAREP HNNKQYQSKN  60
   61 GKYGTNKYNN RNNSQGNAQY YNNRFNNGYR LNNNDYNPAM LPGMQWPANY YAPQMYYIPQ 120
  121 QMVPVASPPY THQPLNTNPE PPSTPKTTKI EITTKTGERL NLKKFHEEKK ASKGEEKNDG 180
  181 VEQKSKSGTP FEKEATPVLP ANEAVKDTLT ETSNEKSTSE AENTKRLFLE QVRLRKAAME 240
  241 RKKNGLISET EKKQETSNHD NTDTTKPNSV IESEPIKEAP KPTGEANEVV IDGKSGASVK 300
  301 TPQHVTGSVT KSVTFNEPEN ESSSQDVDEL VKDDDTTEIS DTTGGKTVNK SDDETINSVI 360
  361 TTEENTVKET EPSTSDIEMP TVSQLLETLG KAQPISDIYE FAYPENVERP DIKYKKPSVK 420
  421 YTYGPTFLLQ FKDKLKFRPD PAWVEAVSSK IVIPPHIARN KPKDSGRFGG DFRSPSMRGM 480
  481 DHTSSSRVSS KRRSKRMGDD RRSNRGYTSR KDREKAAEKA EEQAPKEEIA PLVPSANRWI 540
  541 PKSRVKKTEK KLAPDGKTEL FDKEEVERKM KSLLNKLTLE MFDSISSEIL DIANQSKWED 600
  601 DGETLKIVIE QIFHKACDEP HWSSMYAQLC GKVVKDLDPN IKDKENEGKN GPKLVLHYLV 660
  661 ARCHEEFEKG WADKLPAGED GNPLEPEMMS DEYYIAAAAK RRGLGLVRFI GYLYCLNLLT 720
  721 GKMMFECFRR LMKDLNNDPS EETLESVIEL LNTVGEQFEH DKFVTPQATL EGSVLLDNLF 780
  781 MLLQHIIDGG TISNRIKFKL IDVKELREIK HWNSAKKDAG PKTIQQIHQE EEQLRQKKNS 840
  841 QRSNSRFNNH NQSNSNRYSS NRRNMQNTQR DSFASTKTGS FRNNQRNARK VEEVSQAPRA 900
  901 NMFDALMNND GDSD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CBC2 CDC33 GBP2 KEM1 LHP1 LUC7 NAB3 NAB6 NOP4 NPL3 NRD1 POL2 RAD27 RRP12 SGN1 STO1 TIF1, TIF2 TIF4631 TIF4632
    View Details (MIPS) Mewes HW, et al. (2004) CAF20 TIF4631 TIF4632
    View Details Krogan NJ, et al. (2006) CAF20 CDC33 EAP1 PSP2 SLF1 TIF1, TIF2 TIF4631 TIF4632 YOR287C
    View Details Gavin AC, et al. (2006) CDC33 SBP1 TIF4631 TIF4632
    View Details Gavin AC, et al. (2002) AAR2 ACT1 AIM31 AIR2 ASC1 BRR1 BRX1 BUR2 CBC2 CBF5 CDC33 CFT1 CFT2 CIC1 CKA1 CLF1 CLP1 CSN12 CUS1 CWC2 DBP2 DBP9 DIB1 DRS1 ECM2 ENO2 ERB1 FIP1 FUN12 GAR1 GLC7 HAS1 HCA4 HEK2 HHF1, HHF2 HSH155 HTA1 IML1 KAP95 KRE33 KRR1 LEA1 LHP1 LSM4 LUC7 MAK21 MDN1 MIS1 MPE1 MRP7 MSH4 MSL1 MUD1 NAB3 NAB6 NAM7 NAM8 NHP2 NIP1 NOC2 NOG1 NOP1 NOP12 NOP2 NOP4 NOP56 NOP6 NOP7 NPL3 NRD1 NRP1 NUG1 NUP60 PAP1 PCF11 PFK1 PFS2 POL2 PRP11 PRP19 PRP21 PRP3 PRP31 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP9 PTA1 PTI1 PUB1 PUF6 PUS7 RBG1 REF2 RLP7 RNA14 RNA15 ROM2 RRP12 RSA3 RSE1 SBP1 SCP160 SEC13 SEC31 SEN1 SGN1 SGV1 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNF2 SNP1 SNT309 SNU114 SNU56 SNU66 SNU71 SPP382 SRB2 SRO9 SRP1 SRV2 SSA3 SSU72 STM1 STO1 SUI3 SWI1 SYC1 TAF6 TDH3 THO2 TIF1, TIF2 TIF4631 TIF4632 TYE7 URB1 UTP10 UTP20 UTP21 VID24 VMR1 VPS53 YCL046W YEF3 YGR250C YMR310C YRA2 YSH1 YTH1 YTM1
    View Details Ho Y, et al. (2002) AI1 AIM46 ARE1 CDC10 CDC11 CDC12 CDC3 CDC33 CLU1 FAL1 FET4 FUN12 GCD1 GCD11 GCD2 GCD6 GCN3 GRS1 HAS1 HHO1 IMD2 IMD3 IMD4 KRE33 KRI1 MAG1 MAG2 MGM101 MPH1 MSC3 MSH2 NOC2 NOP12 NOP4 NPL3 OYE2 PDC6 PDI1 PUB1 RET1 RPC82 RPF2 RRP12 SGN1 SPT2 SUI2 SUI3 TIF1, TIF2 TIF4631 TIF4632 UTP22 YGR250C
    View Details Qiu et al. (2008) ANB1 CDC33 TIF1, TIF2 TIF3 TIF4631 TIF4632

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TIF4632 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] deduced N/A No confident structure predictions are available.
    2 View Details [111..166] ab initio 7.56 No description for 1l8mA was found.
    3 View Details [167..414] ab initio 9.96 No description for 1jv2B was found.
    4 View Details [415..472] ab initio 9.96 No description for 1jv2B was found.
    5 View Details [473..555] ab initio 15.0 No description for 1i3qA was found.
    6 View Details [556..691] PSI-BLAST 333.67837 Eukaryotic initiation factor eIF4G
    7 View Details [692..851] PSI-BLAST 333.67837 Eukaryotic initiation factor eIF4G
    8 View Details [852..914] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle