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Protein Overview: NOC2

General Information:
Name(s) found: NOC2 / YOR206W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 710 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Noc2p-Noc3p complex [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Noc1p-Noc2p complex [IPILink to PubMed article]
    Biological Process: ribosomal subunit export from nucleus [TASLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    ribosome assembly [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKVSKSTKK FQSKHLKHTL DQRRKEKIQK KRIQGRRGNK TDQEKADAAG TREQQQLKKS  60
   61 AKEEVFKDMS VETFFEKGIE IPKENKKLKK KTTKEQSDED SSSSEEEEDM GQSMAKLAEK 120
  121 DPEFYKYLEE NDKDLLDFAG TNPLDGIDSQ DEGEDAERNS NIEEKSEQME LEKEKIELSL 180
  181 KLVRKWKKQL HDSPSLKLLR NIISAFKVAV NLNKEENIED YKYAITDEKA FHELMFMVLK 240
  241 DVPQAIQKMA PYKIVKGART LPNGGNVSRV SSIVKSHAGS LLILLNDITN TETAALVLHS 300
  301 VNELMPYLLS YRRILKELIK SIVGVWSTTR ELETQIASFA FLINTTKEFK KSMLETTLKT 360
  361 TYSTFIKSCR KTNMRSMPLI NFQKNSAAEL FGIDEVLGYQ VGFEYIRQLA IHLRNTMNAT 420
  421 TKKSSKINSA EAYKIVYNWQ FCHSLDFWSR VLSFACQPEK ENGSESPLRQ LIYPLVQVTL 480
  481 GVIRLIPTPQ FFPLRFYLIK SLIRLSQNSG VFIPIYPLLS EILTSTAFTK APKKSPNLAA 540
  541 FDFEHNIKCT QAYLNTKIYQ EGLSEQFVDL LGDYFALYCK NIAFPELVTP VIISLRRYIK 600
  601 TSTNVKLNKR LSTVVEKLNQ NSTFIQEKRS DVEFGPTNKS EVSRFLNDVA WNKTPLGSYV 660
  661 AVQREVKEEK ARLMRESMEE QDKERETEEA KLLNSLESDD DNEDVEMSDA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATP22 BRX1 CIC1 DBP10 DBP9 DRS1 EBP2 ERB1 FPR4 HAS1 MAK21 MAK5 MRT4 NIP7 NOC2 NOC3 NOG1 NOP1 NOP12 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 PWP1 RIX1 RIX7 RLP7 RPF1 RPF2 RPL15A RPL16A RPL16B RPL18A, RPL18B RPL25 RPL5 RRP12 RRP5 SPB4 TIF6 URB1 UTP10 UTP22 YTM1
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2006) BRX1 CIC1 ERB1 MAK21 NOC2 NOP4 PUF6 SPB4 YTM1
    View Details Gavin AC, et al. (2002) AAR2 ADE4 ARX1 ASC1 BCP1 BEM2 BFR2 BMS1 BRX1 BUD20 BUD21 CBF5 CIC1 CKA1 CKA2 CKB1 CKB2 CLU1 CMS1 CYR1 CYS4 DBP10 DBP8 DBP9 DCP2 DIA4 DIM1 DIP2 DIS3 DRS1 EBP2 ECM16 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 FAP7 FPR4 FUN12 GAR1 GCN1 GFA1 GLT1 HAS1 HCA4 HDA1 HER1 HHF1, HHF2 HIS3 HSL1 HTA2 IMP3 IMP4 INP2 IPI1 IPI3 KAP123 KRE33 KRR1 LCP5 LHP1 LOC1 LSG1 LTV1 MAK21 MAK5 MDN1 MIS1 MPP10 MRD1 MRP7 MRT4 MVD1 NAN1 NAP1 NHP2 NIP1 NIP7 NMD3 NOB1 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PNO1 POL2 PRE6 PRE9 PRP4 PRP43 PRT1 PUF6 PWP2 RCL1 REI1 RIX1 RIX7 RKM1 RLP24 RLP7 RML2 ROK1 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RRP7 RRP9 RSA3 RSA4 RTG2 RTR1 SAM1 SCL1 SDA1 SEC21 SEC7 SKI2 SLX9 SMB1 SNU114 SNU13 SNU66 SOF1 SPB1 SPB4 SRO9 SSA4 SSF1 TIF1, TIF2 TIF4631 TIF4632 TIF6 TSR1 TUB3 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YGL036W YMR310C YOL098C YOR059C YTM1
    View Details Ho Y, et al. (2002) ACO1 AIM46 ARE1 BRX1 CBF5 CBP2 CCM1 CCT6 CDC14 CDC33 CIC1 CKB1 COX6 DBP7 EBP2 EGD2 ENP2 ERB1 FET4 FUN12 GAR1 GBP2 GND1 GRS1 GUS1 HAS1 HMO1 HTB2 HXT7 IMD1 IMD2 IMD3 IMD4 ISA1 KRE33 KRI1 MAG2 MAK5 MET6 MGM101 MRT4 MSC3 MSS116 MUB1 NIP7 NMD3 NOC2 NOC3 NOG1 NOP1 NOP12 NOP13 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NPL3 NSA1 NSA2 NUG1 OYE2 PDC6 PET127 PHO84 POL5 PRP43 PUF6 PWP1 RLI1 RPF2 RRP1 RRP12 RRP5 SAH1 SCS2 SEC53 SPB4 SSQ1 TIF4631 TIF4632 TIF6 TRA1 TSR1 UBR2 URB1 URB2 UTP10 UTP20 UTP22 YPL009C YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) DBP6 ENP1 LTV1 MAK21 NOC2 NOC3 PXR1 RPL27A RSA3 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOC2 Huh WK, et al. (2003)
    View Data NOC2 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..251] MSA 16.032997 View MSA. No confident structure predictions are available.
    2 View Details [252..426] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [427..710] MSA 1.016967 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle