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Protein Overview: GND1

General Information:
Name(s) found: GND1 / YHR183W [SGD]
Description(s) found:
Found 30 descriptions.
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  • 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 489 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to oxidative stress [IMPLink to PubMed article]
    pentose-phosphate shunt, oxidative branch [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADFGLIGL AVMGQNLILN AADHGFTVCA YNRTQSKVDH FLANEAKGKS IIGATSIEDF  60
   61 ISKLKRPRKV MLLVKAGAPV DALINQIVPL LEKGDIIIDG GNSHFPDSNR RYEELKKKGI 120
  121 LFVGSGVSGG EEGARYGPSL MPGGSEEAWP HIKNIFQSIS AKSDGEPCCE WVGPAGAGHY 180
  181 VKMVHNGIEY GDMQLICEAY DIMKRLGGFT DKEISDVFAK WNNGVLDSFL VEITRDILKF 240
  241 DDVDGKPLVE KIMDTAGQKG TGKWTAINAL DLGMPVTLIG EAVFARCLSA LKNERIRASK 300
  301 VLPGPEVPKD AVKDREQFVD DLEQALYASK IISYAQGFML IREAAATYGW KLNNPAIALM 360
  361 WRGGCIIRSV FLGQITKAYR EEPDLENLLF NKFFADAVTK AQSGWRKSIA LATTYGIPTP 420
  421 AFSTALSFYD GYRSERLPAN LLQAQRDYFG AHTFRVLPEC ASDNLPVDKD IHINWTGHGG 480
  481 NVSSSTYQA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARO9 GND1 GND2
    View Details Ho Y, et al. (2002) AAC3 AAT2 ACC1 ACH1 ACO1 ADH2 ADR1 AFR1 AHA1 AHP1 ARC1 ARF1 ARP2 ATP3 BCK1 BCY1 CAR2 CCT6 CDC14 CDC33 CLU1 COF1 COR1 CPR1 CPR6 CYR1 CYS4 EGD1 EGD2 ERB1 ERG13 ERG6 FOL2 FPR1 FRS2 GAL7 GCD11 GFA1 GND1 GND2 GPG1 GPH1 GRX1 GSP1 GTO1 GUS1 HAS1 HAT1 HAT2 HEF3 HHF1, HHF2 HSP104 HTB1 HTB2 HTZ1 HXT7 IDH1 IDH2 ILV5 IPP1 ISA2 KGD1 KIC1 KIN2 KIP3 LAA1 LHS1 LRO1 LSP1 LYS1 LYS12 MDH1 MET18 MET6 MGE1 MGT1 MKK2 MKT1 MRT4 MUB1 NAN1 NGL2 NOC2 NOC3 NOG1 NOP12 NSA1 NTF2 NUG1 OLA1 OYE2 PDC6 PFK1 PIL1 PMA1 PRM2 PRP43 PUF6 PYC1 PYC2 QCR2 RAD16 RAD7 RCN2 RET1 RIP1 RLI1 RNR2 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPF2 RPN3 RPN6 RPO26 RPO31 RPT3 RSN1 RVS167 SAH1 SAP1 SCP160 SCS2 SEC27 SEC53 SEN15 SES1 SHP1 SIS1 SKG3 SLT2 SMK1 SNO2 SNU13 SOD1 SOF1 SPB4 SPT2 SRP1 SSF1 SSN8 SSQ1 STE23 SUP45 TBS1 TEF4 TFP1 THI22 THO2 THS1 TIF1, TIF2 TIF4631 TIF6 TMA19 TMA29 TPK2 TPK3 TPS2 TSA2 UBA1 UBR1 UBR2 UTP10 UTP22 UTP7 UTP9 VMA4 VMA5 VPS21 WTM1 YBR028C YCK1 YCK2 YCK3 YFL042C YGR111W YHR033W YHR112C YNK1 YPT53 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run DSN1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GND1 Huh WK, et al. (2003)
    View Data GND1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..179] PSI-BLAST 1977.0 6-phosphogluconate dehydrogenase (6PGD); 6-phosphogluconate dehydrogenase
    2 View Details [180..489] PSI-BLAST 1977.0 6-phosphogluconate dehydrogenase (6PGD); 6-phosphogluconate dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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