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Protein Overview: RLI1

General Information:
Name(s) found: RLI1 / YDR091C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 608 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: ribosomal subunit export from nucleus [IMPLink to PubMed article]
    ribosomal large subunit biogenesis [IMPLink to PubMed article]
    translational initiation [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: ATPase activity [ISSLink to PubMed article]
    iron ion binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDKNSRIAI VSADKCKPKK CRQECKRSCP VVKTGKLCIE VTPTSKIAFI SEILCIGCGI  60
   61 CVKKCPFDAI QIINLPTNLE AHVTHRYSAN SFKLHRLPTP RPGQVLGLVG TNGIGKSTAL 120
  121 KILAGKQKPN LGRFDDPPEW QEIIKYFRGS ELQNYFTKML EDDIKAIIKP QYVDNIPRAI 180
  181 KGPVQKVGEL LKLRMEKSPE DVKRYIKILQ LENVLKRDIE KLSGGELQRF AIGMSCVQEA 240
  241 DVYMFDEPSS YLDVKQRLNA AQIIRSLLAP TKYVICVEHD LSVLDYLSDF VCIIYGVPSV 300
  301 YGVVTLPASV REGINIFLDG HIPAENLRFR TEALQFRIAD ATEDLQNDSA SRAFSYPSLK 360
  361 KTQGDFVLNV EEGEFSDSEI LVMMGENGTG KTTLIKLLAG ALKPDEGQDI PKLNVSMKPQ 420
  421 KIAPKFPGTV RQLFFKKIRG QFLNPQFQTD VVKPLRIDDI IDQEVQHLSG GELQRVAIVL 480
  481 ALGIPADIYL IDEPSAYLDS EQRIICSKVI RRFILHNKKT AFIVEHDFIM ATYLADKVIV 540
  541 FEGIPSKNAH ARAPESLLTG CNRFLKNLNV TFRRDPNSFR PRINKLDSQM DKEQKSSGNY 600
  601 FFLDNTGI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HCR1 RLI1 TIF34
    View Details Krogan NJ, et al. (2006) RLI1 YAE1 YNL260C
    View Details Gavin AC, et al. (2006) FUN12 HCR1 NIP1 PRT1 RLI1 RPG1 RPS7A TIF34 TIF35 TIF5
    View Details Gavin AC, et al. (2002) ASC1 ATG9 CLU1 FUN12 GLT1 HCR1 IST2 KTR5 LSG1 NIP1 NOG1 NOP7 PRT1 RIC1 RLI1 RPG1 SPT5 SUA7 SUI1 SUI2 SUI3 SUP45 TIF34 TIF35 TIF5 UTP6 YGL036W
    View Details Ho Y, et al. (2002) AAC3 CBF5 CBP2 CCM1 CDC33 CIC1 CYS4 DBP7 ENP2 GBP2 GND1 GSP1 HAS1 HMO1 HTB2 IMD1 IMD3 ISA1 KRE33 KRI1 MGM101 MSS116 NOC2 NOP12 NOP6 NPL3 PET127 POL5 PRP43 PUF6 PWP1 RLI1 RPF2 RRP12 RRP5 SPT2 SRP1 SSF1 STE23 SUP45 TIF4631 TRA1 TSR1 URB1 URB2 UTP10 UTP20 UTP22 UTP7 YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) NMD3 RLI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RLI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] ORFEUS 8.72 Formate dehydrogenase N, iron-sulfur (beta) subunit; Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor
    2 View Details [74..367] PSI-BLAST 179.9794 Maltose transport protein MalK, C-terminal domain; Maltose transport protein MalK, N-terminal domain
    3 View Details [368..608] PSI-BLAST 100.68867 ABC transporter involved in vitamin B12 uptake, BtuD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.53159718897813 bayes_pls_golite062009
  • transporter activity
    		•  0.768779013335823 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.519838051435455 bayes_pls_golite062009
  • catalytic activity
    		•  0.481338897251745 bayes_pls_golite062009
  • protein binding
    		•  0.247801183125276 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle