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Protein Overview: PWP1

General Information:
Name(s) found: PWP1 / YLR196W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 576 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: rRNA processing [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISATNWVPR GFSSEFPEKY VLDDEEVERI NQLAQLNLDD AKATLEEAEG ESGVEDDAAT  60
   61 GSSNKLKDQL DIDDDLKEYN LEEYDDEEIA DNEGGKDVSM FPGLSNDSDV KFHEGEKGED 120
  121 PYISLPNQED SQEEKQELQV YPSDNLVLAA RTEDDVSYLD IYVYDDGAGF HSSDIPVEEG 180
  181 DEADPDVARG LVRDPALYVH HDLMLPAFPL CVEWLDYKVG SNSEEAANYA AIGTFDPQIE 240
  241 IWNLDCVDKA FPDMILGEPL DNSMVSLKSK KKKKKSKTGH ITTHHTDAVL SMAHNKYFRS 300
  301 VLASTSADHT VKLWDLNSGN AARSLASIHS NKNVSSSEWH MLNGSILLTG GYDSRVALTD 360
  361 VRISDESQMS KYWSAMAGEE IETVTFASEN IILCGTDSGN VYSFDIRNNE NRKPVWTLKA 420
  421 HDAGISTLCS NKFIPGMMST GAMGEKTVKL WKFPLDDATN TKGPSMVLSR DFDVGNVLTS 480
  481 SFAPDIEVAG TMVIGGVNKV LKLWDVFTNR SVRKSFKSEL ENVQARAKEE AQKIGKSSRI 540
  541 ARKYTSNDNP DTVITIDDQG EDEEEREGGD EHDDMA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CBF5 DBP7 EBP2 HHO1 KRE33 KRI1 NOC2 NOP12 NOP2 PRP43 PUF6 PWP1 RPF2 RPL15A RPL5 RPS4B, RPS4A RRP12 STM1 UTP22
    View Details Krogan NJ, et al. (2006) EBP2 PWP1
    View Details Gavin AC, et al. (2002) ACT1 ENO2 FPR4 NAN1 POL5 PWP1 SMC1 TYW1
    View Details Ho Y, et al. (2002) ADH2 AFG2 ALB1 APL2 APL4 APM1 ARX1 BRX1 BUD20 CBF5 CBP2 CCM1 CCT2 CCT3 CCT5 CCT6 CDC16 CDC33 CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 DBP2 DBP7 DRS1 EBP2 EGD1 EHD3 ELA1 ENP2 ERB1 EST1 FPR3 FYV4 GBP2 GDE1 HAS1 HEM15 HHF1, HHF2 HHT1, HHT2 HMO1 HOT1 HSH49 HTA1 HTB1 HTB2 IMD1 IMD3 IMD4 ISA1 KAP95 KRE33 KRI1 KRR1 LHP1 LOC1 MAM33 MES1 MGM101 MKT1 MMS4 MNP1 MRM1 MRPL1 MRPS16 MSS116 MUS81 NHP2 NMA1 NMD3 NOC2 NOC3 NOG1 NOP1 NOP12 NOP13 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NPL3 NSA2 NUG1 PAB1 PDI1 PET127 POB3 POL2 POL5 PRP43 PUF6 PWP1 QCR2 RAD53 RCL1 RIX1 RLI1 RPC10 RPF2 RRP1 RRP12 RRP14 RRP5 RSM24 RSM25 SEC23 SFP1 SPT16 SSF1 TAF14 TCP1 TIF1, TIF2 TIF4631 TIF6 TIS11 TRA1 TRL1 TSR1 TUF1 UBI4 URB1 URB2 UTP10 UTP20 UTP22 VMR1 VPS73 WTM2 YBL044W YER077C YER084W YHB1 YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) NSR1 PWP1 UTP5 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PWP1 and NOP56 Huh WK, et al. (2003)
    View Data PWP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..115] deduced N/A No confident structure predictions are available.
    2 View Details [116..454] PSI-BLAST 69.30103 beta1-subunit of the signal-transducing G protein heterotrimer
    3 View Details [455..576] ORFEUS 11.1 Quinohemoprotein amine dehydrogenase B chain
    4 View Details [407..576] PSI-BLAST 65.69897 No description for 2ovpB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.42725361829881 bayes_pls_golite062009
  • catalytic activity
    		•  0.233388920718075 bayes_pls_golite062009
  • protein binding
    		•  0.220695015309846 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle