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Protein Overview: FPR4

General Information:
Name(s) found: FPR4 / YLR449W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 392 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    chromatin [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of histone H3-K36 methylation [IMPLink to PubMed article]
    chromatin silencing at rDNA [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article][IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    histone peptidyl-prolyl isomerization [IDALink to PubMed article]
    nucleosome assembly [IDALink to PubMed article]
    Molecular Function: histone binding [IDALink to PubMed articleLink to PubMed article]
    peptidyl-prolyl cis-trans isomerase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDMLPLATY SLNVEPYSPT PALNFKIPVT IRITMAAIDP EPFDDDKKPS TLRIIKRNPE  60
   61 LTRGEYYNQD NNDGLEEDES ESEQEADVPK RSVKSKKGKA VEQSESEDSE DENEIDDEFE 120
  121 ECVLLTLSPK GQYQQALDIT IAPEEDVQFV VTGSYTISLT GNYVKHPFDN SSDSDEDEED 180
  181 YYSDEESSNG EEEEEEEEED DEELSSGDDD LDDLVDASDI ESRLDELVKK DEKKKNNKKD 240
  241 SKRKHEEDEE ESAKPAEKKQ TTKKDKKAEK VKDSEESKPK PKTKLLEGGI IIEDRVTGKG 300
  301 PHAKKGTRVG MRYVGKLKNG KVFDKNTKGK PFVFKLGQGE VIKGWDIGVA GMAVGGERRI 360
  361 VIPAPYAYGK QALPGIPANS ELTFDVKLVS MK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) Manuscript in preparation. BRX1 CIC1 DBP10 ERB1 FPR4 HAS1 MAK21 NIP7 NOC2 NOC3 NOG1 NOP2 NUG1 PUF6 RLP7 RPF1 RPS4B, RPS4A SPB4
    View Details Gavin AC, et al. (2006) ARX1 FPR4 MRT4 NIP7 NOG1 NOG2 NOP13 NOP2 NSA2 NUG1 PUF6 RIX7 RPF2 RPL20A SDA1 TIF6
    View Details Gavin AC, et al. (2002) ACT1 ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ENO2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAN1 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 POL5 PRT1 PUF6 PWP1 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMC1 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 TYW1 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) ADH4 BRX1 CFT1 CIC1 CLU1 EBP2 ERB1 EXG1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 GSY1 GSY2 HER1 KEL1 MDH1 MHP1 MRT4 NOC3 NOG1 NOP15 NOP16 NOP2 NOP7 NSA1 PDC5 PIB2 POL30 REG1 RLP7 RPF2 RRP17 SCD5 SCS2 SDS22 SEN1 SPB1 SUI2 SUI3 THI21 TIF6 YEN1 YPI1 YTM1
    View Details Qiu et al. (2008) ARP4 BRX1 DAD3 DAD4 EMG1 ENP1 FPR4 GAR1 HHO1 HSK3 KAE1 KRR1 NOP13 NOP2 NOP7 NSA1 NUG1 PCC1 PXR1 RPL27A SIR3 SIR4 SLX9 UTP15 UTP8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FPR4 Huh WK, et al. (2003)
    View Data FPR4 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] ORFEUS 10.47 No description for 1l8mA was found.
    2 View Details [72..150] ORFEUS 10.47 No description for 1l8mA was found.
    3 View Details [151..220] ORFEUS 10.47 No description for 1l8mA was found.
    4 View Details [221..283] ORFEUS 10.47 No description for 1l8mA was found.
    5 View Details [284..392] PSI-BLAST 235.38764 Calcineurin (FKBP12.6)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • histone binding
    		•  3.35045437512493 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.43975322634809 bayes_pls_golite062009
  • binding
    		•  2.31105760892804 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.24162845592598 bayes_pls_golite062009
  • protein binding
    		•  2.12153134547445 bayes_pls_golite062009
  • DNA binding
    		•  2.08668076342056 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.82337497151874 bayes_pls_golite062009
  • transcription activator activity
    		•  1.75815621070125 bayes_pls_golite062009
  • transcription factor binding
    		•  1.01646096561699 bayes_pls_golite062009
  • Tat protein binding
    		•  0.86034982538949 bayes_pls_golite062009
  • enzyme binding
    		•  0.420979974123408 bayes_pls_golite062009
  • hydrolase activity
    		•  0.319361545733709 bayes_pls_golite062009
  • catalytic activity
    		•  0.290929394811364 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.290017406252516 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.237741029116502 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.196866743343878 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.186970052809736 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.1843930975799 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.0973531211151839 bayes_pls_golite062009
  • NF-kappaB binding
    		•  0.00132024988427304 bayes_pls_golite062009
    3
    Term Confidence Notes
  • intracellular ligand-gated calcium channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • ryanodine-sensitive calcium-release channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • macrolide binding
    		•  7.31599503004442 bayes_pls_golite062009
  • FK506 binding
    		•  7.22442625476031 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
    		•  6.4374377859142 bayes_pls_golite062009
  • cation channel activity
    		•  6.06732269872248 bayes_pls_golite062009
  • ion channel activity
    		•  5.45007096522107 bayes_pls_golite062009
  • channel activity
    		•  5.32426176964634 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.28960420749143 bayes_pls_golite062009
  • gated channel activity
    		•  5.28074654906904 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.64797495383748 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • receptor activity
    		•  1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68688812199737 bayes_pls_golite062009
  • kinase activity
    		•  1.67904764195462 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57898291235576 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • signal transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • protein kinase activity
    		•  1.45320632553313 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.40573056630714 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • transferase activity
    		•  1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.32709321745178 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • protein binding
    		•  1.08765413491791 bayes_pls_golite062009
  • SMAD binding
    		•  1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.780499202755666 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.763739321802433 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • activin binding
    		•  0.33489895389042 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • histone binding
    		•  0.221748741603068 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle