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Protein Overview: ERB1

General Information:
Name(s) found: ERB1 / YMR049C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 807 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: rRNA processing [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMAKNNKTTE AKMSKKRAAS EESDVEEDED KLLSVDGLID AEASESDEDD DEYESAVEEK  60
   61 ESSSDKEAQD DSDDDSDAEL NKLLAEEEGD GEEDYDSSEF SDDTTSLTDR LSGVKLQTIV 120
  121 DPNIYSKYAD GSDRIIKPEI NPVYDSDDSD AETQNTIGNI PLSAYDEMPH IGYDINGKRI 180
  181 MRPAKGSALD QLLDSIELPE GWTGLLDKNS GSSLNLTKEE LELISKIQRN EQTDDSINPY 240
  241 EPLIDWFTRH EEVMPLTAVP EPKRRFVPSK NEAKRVMKIV RAIREGRIIP PKKLKEMKEK 300
  301 EKIENYQYDL WGDSTETNDH VMHLRAPKLP PPTNEESYNP PEEYLLSPEE KEAWENTEYS 360
  361 ERERNFIPQK YSALRKVPGY GESIRERFER SLDLYLAPRV RKNKLNIDPN SLIPELPSPK 420
  421 DLRPFPIRCS TIYAGHKGKV RTLSIDPSGL WLATGSDDGT VRVWEILTGR EVYRTTLIDD 480
  481 EENPDYHIEC IEWNPDANNG ILAVAVGENI HLIVPPIFGY DIENNGKTKI EDGFGYDTFG 540
  541 TVKKSNLEVN ENGDGDEDGE NESAKNAVKK QVAQWNKPSQ KQLEKDICIT ISCKKTVKKL 600
  601 SWHRKGDYFV TVQPDSGNTS VLIHQVSKHL TQSPFKKSKG IIMDAKFHPF KPQLFVCSQR 660
  661 YVRIYDLSQQ ILVKKLLPGA RWLSKIDIHP RGDNLIASSF DKRVLWHDLD LASTPYKTLR 720
  721 YHEKAVRSVN FHKKLPLFSS AADDGTIHVF HATVYDDMMK NPMIVPLKKL TGHKVINSLG 780
  781 VLDAIWHPRE AWLFSAGADN TARLWTT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BRX1 CIC1 DBP10 DBP9 DRS1 EBP2 ERB1 FPR4 HAS1 KRE33 MAK21 MAK5 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPL25 RRP1 SDA1 SPB1 SPB4 TIF6 URB1 UTP10 YTM1
    View Details Krogan NJ, et al. (2006) DRS1 ERB1 HAA1 HRQ1 MKT1 STE20 UBP1
    View Details Gavin AC, et al. (2006) BRX1 ERB1 MAK21 NOC2 NOP4 PUF6
    View Details Gavin AC, et al. (2002) AAR2 ARX1 ASC1 BEM2 BMS1 BRX1 BUD20 CBF5 CDC33 CIC1 CLF1 CLU1 CWC23 CYR1 CYS4 DBP10 DBP9 DCP2 DHH1 DIB1 DRS1 EBP2 ERB1 FPR4 FUN12 GAR1 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRR1 KRS1 LHP1 LOC1 LSG1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAK21 MAK5 MDN1 MIS1 MRP7 MRT4 NAM7 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NSA1 NSA2 NUG1 PAT1 POL2 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SMD2 SNU114 SNU13 SNU23 SNU66 SPB1 SPB4 SPP382 SQS1 SRO9 SSF1 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP20 UTP21 UTP22 YGL036W YMR310C YTM1
    View Details Ho Y, et al. (2002) ACO1 ADH2 BRX1 CBF5 CBP2 CCT6 CDC14 CDC16 CDC33 CFT1 CIC1 CKA1 CKB1 CKB2 CLU1 DBP2 DBP7 DRS1 DUG2 EBP2 EGD1 EGD2 ELA1 ENP2 ERB1 EXG1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GND1 GPH1 GUS1 HAS1 HER1 HHF1, HHF2 HHT1, HHT2 HOT1 HTA1 HTB1 HTB2 HUL5 HXT7 KAP95 KEL1 KRE33 KRI1 KRR1 LOC1 MAK11 MES1 MET6 MGM101 MHP1 MKT1 MMS4 MNP1 MRT4 MSS116 MUB1 MUS81 NHP2 NOC2 NOC3 NOG1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NUG1 PDI1 PIB2 POB3 PRP43 PUF6 PWP1 RAD53 REG1 RLP7 ROK1 RPC10 RPF1 RPF2 RRP17 RRP5 SAH1 SCD5 SCS2 SDS22 SEC23 SEC53 SEN1 SPB1 SPB4 SPT16 SRP54 SSF1 SSQ1 SUI2 SUI3 TAF14 THI21 TIF1, TIF2 TIF4631 TIF6 TMA108 TSR1 UBI4 UBR2 URB2 UTP10 UTP15 UTP22 VPS35 YBR242W YER084W YHB1 YPD1 YRA1 YTM1
    View Details Qiu et al. (2008) DBP3 DBP7 ERB1 GAR1 NOP4 NSA1 NSR1 NUG1 PWP2 PXR1 RRP9 UTP13 UTP15 UTP4 UTP5 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERB1 and NOP56 Huh WK, et al. (2003)
    View Data ERB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..308] MSA 3.054996 View MSA. No confident structure predictions are available.
    2 View Details [309..368] deduced N/A No confident structure predictions are available.
    3 View Details [369..751] PSI-BLAST 72.69897 beta1-subunit of the signal-transducing G protein heterotrimer
    4 View Details [752..807] PSI-BLAST 59.69897 Tup1, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle