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Protein Overview: LST8

General Information:
Name(s) found: LST8 / YNL006W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 303 amino acids

    Gene Ontology:
    Cellular Component: TORC2 complex [IPILink to PubMed article]
    extrinsic to internal side of plasma membrane [IDALink to PubMed article]
    Golgi membrane [IDALink to PubMed article]
    endosome membrane [IDALink to PubMed article]
    TORC1 complex [IPILink to PubMed article]
    peripheral to membrane of membrane fraction [IDALink to PubMed article]
    Biological Process: fungal-type cell wall organization [IMPLink to PubMed article]
    regulation of cell growth [IPILink to PubMed article]
    signal transduction [IMPLink to PubMed article]
    establishment or maintenance of actin cytoskeleton polarity [IMPLink to PubMed article]
    mitochondria-nucleus signaling pathway [IMPLink to PubMed article]
    transport [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    protein kinase activator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVILVSAGY DHTIRFWEAL TGVCSRTIQH SDSQVNRLEI TNDKKLLATA GHQNVRLYDI  60
   61 RTTNPNPVAS FEGHRGNVTS VSFQQDNRWM VTSSEDGTIK VWDVRSPSIP RNYKHNAPVN 120
  121 EVVIHPNQGE LISCDRDGNI RIWDLGENQC THQLTPEDDT SLQSLSMASD GSMLAAANTK 180
  181 GNCYVWEMPN HTDASHLKPV TKFRAHSTYI TRILLSSDVK HLATCSADHT ARVWSIDDDF 240
  241 KLETTLDGHQ RWVWDCAFSA DSAYLVTASS DHYVRLWDLS TREIVRQYGG HHKGAVCVAL 300
  301 NDV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ACC1 ADR1 ATP3 CCT3 COP1 CPA2 DEF1 FOL2 GAL7 IDH1 LSC1 LST8 LYS12 PHO86 POR1 RPN12 RRP3 SIP1 SLC1 STI1 YBT1 YFR039C YKU80 YML020W
    View Details Qiu et al. (2008) AVO2 BIT61 LST8 SCD5 SLM1 SLM2 TCO89 TOR1 TOR2 TSC11

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LST8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..303] PSI-BLAST 217.70927 Tup1, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle