Protein Overview: SCD5

General Information:
Name(s) found:	SCD5 / YOR329C [SGD]
Description(s) found: Found 32 descriptions. SHOW ALL	Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency [SGD]
Organism:	Saccharomyces cerevisiae
Length:	872 amino acids
Gene Ontology:
Cellular Component:	peripheral to membrane of membrane fraction [IDA] actin cortical patch [IDA]
Biological Process:	cortical actin cytoskeleton organization [IMP] actin filament organization [TAS] endocytosis [TAS] protein secretion [IGI][IMP]
Molecular Function:	protein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFDWLNVPG LDLSSGDQAE KRPSNGLGPP SVSFDFGINT AAPHDSSFWD QGSRSHSDTT  60
   61 LSYRNNHSNT AADNATNVSS PQKDNPPNGE VRTLSGGDVY AESPEDMQVP LSLSQNQLTH 120
  121 EEIRTYLRWY HYICLRTHGK LVRLNDVFRF LTNFNLSQKV KDRIVEIFRS CKNALNIGQF 180
  181 FAVLRLVSRA IIYGILPLRR MILEKAPVPK PRPILSSENH EEVYEEVEDD DSSAKTGDQK 240
  241 VDFDSFASLL LTGKTTRKRV RRRIKNLNFK SKKVRFSEHI TFQDPPNLNQ ESSNNSEARK 300
  301 QDPDAEDEDQ DSNNDSPLDF TLPMDQLLKR LYKRRKNSGL VSSLPSEQQE TEEEKKVLED 360
  361 MKDSLSHFKQ IQTVDSASLP ISSVFLQNGN TLPTSNVNNT TVPQQLPLEP LKPTATGSAN 420
  421 HLVREEYNQG LHPSNGAIQT GLQPLKPTAT GSANYLMRSH MEQPQSIKPS STPETVTNSG 480
  481 GLQPLKPTAT GSANYLMKQH ISPSVNNPVS SMFQAQFTNQ SSSPQSTGPA FLNSPNITLP 540
  541 QSNQQQPYQE VNPTQAKIEP SNISPQHTYS NNVRINNGNI VSMPKVEITG AFPPQNTLPQ 600
  601 HQQSHLLSPQ NTIPQHQRSQ LISPQNTFTQ NQPILSPQHT YSNNQATMIS PQNTYTNNQQ 660
  661 QPQHLPPPPP PRAQQQQQGA IVPPQHMYSN VQKQNNLVPT QPSYTNSPSI QSPNFLSPQN 720
  721 AANSYFQSLL SSSPSPNPTP SNASTVNGNN ASNGISSFQN TSAAMNNTQS HQTYIQQQQQ 780
  781 QQTQQRIYGG QLSQMQQHPG QLHLNNSDIH SQPNKPNYGM LGQQVHQQQQ QQQQQFPFTA 840
  841 DVNRSNSSDI LGNLQSLQQQ VDALQIQYNR RP

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		CFT1 CIC1 CLU1 ERB1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 HER1 KEL1 MHP1 NSA1 REG1 RRP17 SCD5 SDS22 SEN1 SPB1 SUI2 SUI3 YTM1
View Details	Qiu et al. (2008)		ABP1 ACT1 AIP1 ATG20 COF1 CRN1 EDE1 END3 LAS17 LST8 PAN1 SCD5 SLA1 SLA2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GLC7	SCD5	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SCD5	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..205]	deduced	N/A	No confident structure predictions are available.
2	View Details	[206..535]	MSA	4.304997	View MSA. No confident structure predictions are available.
3	View Details	[536..712]	PSI-BLAST	2.045757	Sec24
4	View Details	[713..872]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2