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Protein Overview: SLA2

General Information:
Name(s) found: SLA2 / YNL243W [SGD]
Description(s) found:
Found 14 descriptions.
SHOW ALL
  • Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 968 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    actin cortical patch [IDALink to PubMed article]
    Biological Process: bipolar cellular bud site selection [IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    exocytosis [IMPLink to PubMed article]
    Molecular Function: protein binding, bridging [IGILink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRIDSDLQK ALKKACSVEE TAPKRKHVRA CIVYTWDHQS SKAVFTTLKT LPLANDEVQL  60
   61 FKMLIVLHKI IQEGHPSALA EAIRDRDWIR SLGRVHSGGS SYSKLIREYV RYLVLKLDFH 120
  121 AHHRGFNNGT FEYEEYVSLV SVSDPDEGYE TILDLMSLQD SLDEFSQIIF ASIQSERRNT 180
  181 ECKISALIPL IAESYGIYKF ITSMLRAMHR QLNDAEGDAA LQPLKERYEL QHARLFEFYA 240
  241 DCSSVKYLTT LVTIPKLPVD APDVFLINDV DESKEIKFKK REPSVTPART PARTPTPTPP 300
  301 VVAEPAISPR PVSQRTTSTP TGYLQTMPTG ATTGMMIPTA TGARNAIFPQ ATAQMQPDFW 360
  361 ANQQAQFANE QNRLEQERVQ QLQQQQAQQE LFQQQLQKAQ QDMMNMQLQQ QNQHQNDLIA 420
  421 LTNQYEKDQA LLQQYDQRVQ QLESEITTMD STASKQLANK DEQLTALQDQ LDVWERKYES 480
  481 LAKLYSQLRQ EHLNLLPRFK KLQLKVNSAQ ESIQKKEQLE HKLKQKDLQM AELVKDRDRA 540
  541 RLELERSINN AEADSAAATA AAETMTQDKM NPILDAILES GINTIQESVY NLDSPLSWSG 600
  601 PLTPPTFLLS LLESTSENAT EFATSFNNLI VDGLAHGDQT EVIHCVSDFS TSMATLVTNS 660
  661 KAYAVTTLPQ EQSDQILTLV KRCAREAQYF FEDLMSENLN QVGDEEKTDI VINANVDMQE 720
  721 KLQELSLAIE PLLNIQSVKS NKETNPHSEL VATADKIVKS SEHLRVDVPK PLLSLALMII 780
  781 DAVVALVKAA IQCQNEIATT TSIPLNQFYL KNSRWTEGLI SAAKAVAGAT NVLITTASKL 840
  841 ITSEDNENTS PEQFIVASKE VAASTIQLVA ASRVKTSIHS KAQDKLEHCS KDVTDACRSL 900
  901 GNHVMGMIED DHSTSQQQQP LDFTSEHTLK TAEMEQQVEI LKLEQSLSNA RKRLGEIRRH 960
  961 AYYNQDDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LSB3 SLA2
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Gavin AC, et al. (2006) END3 LSB3 SLA2
    View Details Gavin AC, et al. (2002) BSP1 BZZ1 CHC1 ECM25 EDE1 END3 INP52 LAS17 LSB3 RAD51 SLA1 SLA2 STM1 SYP1 TFP1 VRP1 YDR348C YPT7 YSC84
    View Details Qiu et al. (2008) ABP1 ABP140 ACT1 AIP1 ARP2 BEM1 BNI1 BNI4 BSP1 BUD6 CAP1 CAP2 COF1 CRN1 EDE1 END3 ENT1 ENT2 ENT3 GLK1 GYL1 INP53 IQG1 LAS17 MYO5 PAN1 PFY1 PXL1 RVS161 RVS167 SAC6 SCD5 SCP1 SLA1 SLA2 SPA2 SRV2 TPM1 TPM2 TWF1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SLA2 YSC84 2 Drees BL, et al. (2001)
    View Screen SLA2 APP1 2 Drees BL, et al. (2001)
    View Screen SLA2 CLA4 2 Drees BL, et al. (2001)
    View Screen SLA2 HUA2 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..311] PSI-BLAST 16.30103 Heavy meromyosin subfragment
    2 View Details [312..380] PSI-BLAST 8.69897 Tropomyosin
    3 View Details [381..582] PSI-BLAST 8.69897 Tropomyosin
    4 View Details [583..731] ORFEUS 11.77 alpha-actinin
    5 View Details [732..844] ORFEUS 11.77 alpha-actinin
    6 View Details [845..968] ORFEUS 11.77 alpha-actinin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • actin binding
    		•  6.7826347563455 bayes_pls_golite062009
  • actin filament binding
    		•  6.08621312196526 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  5.50691080671938 bayes_pls_golite062009
  • protein binding
    		•  2.87709153890286 bayes_pls_golite062009
  • binding
    		•  2.49469149705983 bayes_pls_golite062009
  • protein complex binding
    		•  2.37932817431952 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.32024661156379 bayes_pls_golite062009
  • tubulin binding
    		•  1.84664263423017 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  1.75895219767628 bayes_pls_golite062009
  • microtubule binding
    		•  1.73722673330179 bayes_pls_golite062009
  • integrin binding
    		•  1.64255629749418 bayes_pls_golite062009
  • ZASP binding
    		•  1.27608099013325 bayes_pls_golite062009
  • signal transducer activity
    		•  0.912743261494203 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.912743261494203 bayes_pls_golite062009
  • receptor binding
    		•  0.825016282154134 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.714083718942824 bayes_pls_golite062009
  • structural molecule activity
    		•  0.664059577144832 bayes_pls_golite062009
  • vinculin binding
    		•  0.636982818401655 bayes_pls_golite062009
  • FATZ 1 binding
    		•  0.629986691164199 bayes_pls_golite062009
  • FATZ binding
    		•  0.629986691164199 bayes_pls_golite062009
  • titin Z domain binding
    		•  0.629986691164199 bayes_pls_golite062009
  • SNARE binding
    		•  0.580419052512979 bayes_pls_golite062009
  • syntaxin binding
    		•  0.488853634381724 bayes_pls_golite062009
  • identical protein binding
    		•  0.445600866032313 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0899793436095582 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.06225532254104 bayes_pls_golite062009
    6
    Term Confidence Notes
  • actin binding
    		•  6.7826347563455 bayes_pls_golite062009
  • actin filament binding
    		•  6.08621312196526 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  5.50691080671938 bayes_pls_golite062009
  • protein binding
    		•  2.87709153890286 bayes_pls_golite062009
  • binding
    		•  2.49469149705983 bayes_pls_golite062009
  • protein complex binding
    		•  2.37932817431952 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.32024661156379 bayes_pls_golite062009
  • tubulin binding
    		•  1.84664263423017 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  1.75895219767628 bayes_pls_golite062009
  • microtubule binding
    		•  1.73722673330179 bayes_pls_golite062009
  • integrin binding
    		•  1.64255629749418 bayes_pls_golite062009
  • ZASP binding
    		•  1.27608099013325 bayes_pls_golite062009
  • signal transducer activity
    		•  0.912743261494203 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.912743261494203 bayes_pls_golite062009
  • receptor binding
    		•  0.825016282154134 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.714083718942824 bayes_pls_golite062009
  • structural molecule activity
    		•  0.664059577144832 bayes_pls_golite062009
  • vinculin binding
    		•  0.636982818401655 bayes_pls_golite062009
  • FATZ 1 binding
    		•  0.629986691164199 bayes_pls_golite062009
  • FATZ binding
    		•  0.629986691164199 bayes_pls_golite062009
  • titin Z domain binding
    		•  0.629986691164199 bayes_pls_golite062009
  • SNARE binding
    		•  0.580419052512979 bayes_pls_golite062009
  • syntaxin binding
    		•  0.488853634381724 bayes_pls_golite062009
  • identical protein binding
    		•  0.445600866032313 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0899793436095582 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.06225532254104 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle