YRC Public Data Repository - Protein Structure Prediction

Protein:	SLA2
Organism:	Saccharomyces cerevisiae
Length:	968 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLA2.

Description	E-value	Query Range	Subject Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1	0.0	[2..963]	[848..1815]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1	0.0	[2..963]	[851..1818]
gi\|9800488, gi\|1... - gi\|9800488\|gb\|AAF99315.1\|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi\|165973976\|...	0.0	[2..963]	[851..1818]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..963]	[848..1815]

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Predicted Domain #1

Region A:
Residues: [1-311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRIDSDLQK ALKKACSVEE TAPKRKHVRA CIVYTWDHQS SKAVFTTLKT LPLANDEVQL  60
   61 FKMLIVLHKI IQEGHPSALA EAIRDRDWIR SLGRVHSGGS SYSKLIREYV RYLVLKLDFH 120
  121 AHHRGFNNGT FEYEEYVSLV SVSDPDEGYE TILDLMSLQD SLDEFSQIIF ASIQSERRNT 180
  181 ECKISALIPL IAESYGIYKF ITSMLRAMHR QLNDAEGDAA LQPLKERYEL QHARLFEFYA 240
  241 DCSSVKYLTT LVTIPKLPVD APDVFLINDV DESKEIKFKK REPSVTPART PARTPTPTPP 300
  301 VVAEPAISPR P

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.30103
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [312-380]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSQRTTSTPT GYLQTMPTGA TTGMMIPTAT GARNAIFPQA TAQMQPDFWA NQQAQFANEQ  60
   61 NRLEQERVQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.69897
Match:	1c1gA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [381-582]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLQQQQAQQE LFQQQLQKAQ QDMMNMQLQQ QNQHQNDLIA LTNQYEKDQA LLQQYDQRVQ  60
   61 QLESEITTMD STASKQLANK DEQLTALQDQ LDVWERKYES LAKLYSQLRQ EHLNLLPRFK 120
  121 KLQLKVNSAQ ESIQKKEQLE HKLKQKDLQM AELVKDRDRA RLELERSINN AEADSAAATA 180
  181 AAETMTQDKM NPILDAILES GI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.69897
Match:	1c1gA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [583-731]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTIQESVYNL DSPLSWSGPL TPPTFLLSLL ESTSENATEF ATSFNNLIVD GLAHGDQTEV  60
   61 IHCVSDFSTS MATLVTNSKA YAVTTLPQEQ SDQILTLVKR CAREAQYFFE DLMSENLNQV 120
  121 GDEEKTDIVI NANVDMQEKL QELSLAIEP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.77
Match:	1hciA
Description:	alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [732-844]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLNIQSVKSN KETNPHSELV ATADKIVKSS EHLRVDVPKP LLSLALMIID AVVALVKAAI  60
   61 QCQNEIATTT SIPLNQFYLK NSRWTEGLIS AAKAVAGATN VLITTASKLI TSE

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.77
Match:	1hciA
Description:	alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	6.7826347563455	bayes_pls_golite062009
actin filament binding	6.08621312196526	bayes_pls_golite062009
cytoskeletal protein binding	5.50691080671938	bayes_pls_golite062009
protein binding	2.87709153890286	bayes_pls_golite062009
binding	2.49469149705983	bayes_pls_golite062009
protein complex binding	2.37932817431952	bayes_pls_golite062009
structural constituent of muscle	2.32024661156379	bayes_pls_golite062009
tubulin binding	1.84664263423017	bayes_pls_golite062009
structural constituent of cytoskeleton	1.75895219767628	bayes_pls_golite062009
microtubule binding	1.73722673330179	bayes_pls_golite062009
integrin binding	1.64255629749418	bayes_pls_golite062009
ZASP binding	1.27608099013325	bayes_pls_golite062009
signal transducer activity	0.912743261494203	bayes_pls_golite062009
molecular transducer activity	0.912743261494203	bayes_pls_golite062009
receptor binding	0.825016282154134	bayes_pls_golite062009
protein dimerization activity	0.714083718942824	bayes_pls_golite062009
structural molecule activity	0.664059577144832	bayes_pls_golite062009
vinculin binding	0.636982818401655	bayes_pls_golite062009
FATZ 1 binding	0.629986691164199	bayes_pls_golite062009
FATZ binding	0.629986691164199	bayes_pls_golite062009
titin Z domain binding	0.629986691164199	bayes_pls_golite062009
SNARE binding	0.580419052512979	bayes_pls_golite062009
syntaxin binding	0.488853634381724	bayes_pls_golite062009
identical protein binding	0.445600866032313	bayes_pls_golite062009
transcription activator activity	0.0899793436095582	bayes_pls_golite062009
transcription regulator activity	0.06225532254104	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [845-968]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNENTSPEQF IVASKEVAAS TIQLVAASRV KTSIHSKAQD KLEHCSKDVT DACRSLGNHV  60
   61 MGMIEDDHST SQQQQPLDFT SEHTLKTAEM EQQVEILKLE QSLSNARKRL GEIRRHAYYN 120
  121 QDDD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.77
Match:	1hciA
Description:	alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	6.7826347563455	bayes_pls_golite062009
actin filament binding	6.08621312196526	bayes_pls_golite062009
cytoskeletal protein binding	5.50691080671938	bayes_pls_golite062009
protein binding	2.87709153890286	bayes_pls_golite062009
binding	2.49469149705983	bayes_pls_golite062009
protein complex binding	2.37932817431952	bayes_pls_golite062009
structural constituent of muscle	2.32024661156379	bayes_pls_golite062009
tubulin binding	1.84664263423017	bayes_pls_golite062009
structural constituent of cytoskeleton	1.75895219767628	bayes_pls_golite062009
microtubule binding	1.73722673330179	bayes_pls_golite062009
integrin binding	1.64255629749418	bayes_pls_golite062009
ZASP binding	1.27608099013325	bayes_pls_golite062009
signal transducer activity	0.912743261494203	bayes_pls_golite062009
molecular transducer activity	0.912743261494203	bayes_pls_golite062009
receptor binding	0.825016282154134	bayes_pls_golite062009
protein dimerization activity	0.714083718942824	bayes_pls_golite062009
structural molecule activity	0.664059577144832	bayes_pls_golite062009
vinculin binding	0.636982818401655	bayes_pls_golite062009
FATZ 1 binding	0.629986691164199	bayes_pls_golite062009
FATZ binding	0.629986691164199	bayes_pls_golite062009
titin Z domain binding	0.629986691164199	bayes_pls_golite062009
SNARE binding	0.580419052512979	bayes_pls_golite062009
syntaxin binding	0.488853634381724	bayes_pls_golite062009
identical protein binding	0.445600866032313	bayes_pls_golite062009
transcription activator activity	0.0899793436095582	bayes_pls_golite062009
transcription regulator activity	0.06225532254104	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: