YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: CIC1

General Information:
Name(s) found: CIC1 / YHR052W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: proteasome complex [IDALink to PubMed article][IPILink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: protein catabolic process [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    ribosomal large subunit biogenesis [IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: protein binding, bridging [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKKSNSKKS TPVSTPSKEK KKVIEKKSST AIPRERVIKA VNELIKFTSK PQDENNEEGN  60
   61 NGKKNLLEDD EEELKKDLQL IVVNNKSFTG TSKSFKLKLL NVKHSFYKPW KEASATAVKD 120
  121 FKVLLILKDS DIKKVSEDDL FDQLDSEGIK VDEIICGKDL KTVYKAYEAR NAFISQFSLI 180
  181 LADDSIVTSL PKLMGGKAYN KVETTPISIR THANKEFSLT TLTNNIKKVY MNQLPVKLPR 240
  241 GTTLNVHLGN LEWLRPEEFV DNVELISEQL IKAYQIRSIF IKTNRSPVLP LYYNQDVLDE 300
  301 LEAKKDKIEE THEDDMVTID GVQVHLSTFN KGLMEIANPS ELGSIFSKQI NNAKKRSSSE 360
  361 LEKESSESEA VKKAKS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BRX1 CIC1 DBP10 DBP9 DRS1 EBP2 ERB1 FPR4 HAS1 IPI3 LOC1 MAK21 MAK5 MDN1 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP12 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPF2 RPL1A, RPL1B RPL25 RRP12 SDA1 SPB1 SPB4 TIF6 URB1 UTP10 UTP20 YTM1
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2006) BRX1 CIC1 EBP2 IPI1 MAK21 NOC2 NOP4 RPL31B SPB4 YTM1
    View Details Gavin AC, et al. (2002) AAR2 ARX1 BEM2 BMS1 BRX1 BUD20 CBF5 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 FUN12 GAR1 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRR1 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRP7 MRT4 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NSA1 NSA2 NUG1 POL2 PRP4 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SNU114 SNU13 SNU66 SPB1 SPB4 SRO9 SSF1 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP20 UTP21 UTP22 YGL036W YMR310C YTM1
    View Details Ho Y, et al. (2002) AAC3 ACO1 ADH2 AIM21 APL2 APL4 APM1 ARP4 ASA1 ATG17 ATG29 ATP3 BMS1 BRX1 BUD20 CBF5 CBP2 CCM1 CDC33 CDC53 CFT1 CIC1 CIS1 CKA1 CKA2 CKB1 CKB2 CLU1 COF1 CPR1 CTF4 CYS4 DBP10 DBP7 DED81 DIA2 DNL4 DRS1 DUG2 EBP2 EHD3 ELA1 ENP1 ENP2 ERB1 EXG1 FIN1 FIP1 FOL2 FPR3 FPR4 GBP2 GDE1 GLC7 GLC8 GPH1 GPI15 GRH1 HAP2 HAP5 HAS1 HER1 HHF1, HHF2 HMO1 HOT1 HTA1 HTB1 HTB2 HYP2 ILS1 IMD1 IMD2 IMD3 IPP1 ISA1 KEL1 KGD1 KRE33 KRI1 KRR1 LOC1 LSM2 LST4 MAK16 MAK5 MAM33 MCM2 MCM3 MCM5 MDH1 MGM101 MHP1 MRPL1 MRPS16 MRT4 MSS116 MTQ1 NAP1 NIP7 NMA1 NMD3 NMD5 NOC2 NOC3 NOG1 NOP1 NOP12 NOP13 NOP15 NOP16 NOP2 NOP4 NOP58 NOP6 NOP7 NPL3 NSA1 NSA2 OYE2 PAB1 PDI1 PET127 PIB2 POB3 POL2 POL5 PRP43 PSE1 PUF6 PWP1 RCL1 REG1 RHR2 RLI1 RLP24 RLP7 ROK1 RPF1 RPF2 RPL5 RRP12 RRP14 RRP17 RRP5 RRT6 SAH1 SAP190 SCD5 SCS2 SDS22 SEH1 SEN1 SFP1 SKP1 SLT2 SPB1 SPE3 SPT16 SRP54 SSF1 SSF2 SSK2 SSZ1 SUI2 SUI3 TEF4 THI21 TIF1, TIF2 TIF4631 TIF6 TMA108 TRA1 TRL1 TSR1 TUF1 URB1 URB2 UTP10 UTP15 UTP20 UTP22 VMR1 VPS35 VPS73 WTM2 YAK1 YBL104C YBR242W YFL006W YPD1 YPP1 YRA1 YRA2 YTM1
    View Details Qiu et al. (2008) BRX1 CIC1 DRS1 GAR1 NOG1 NOP13 NSR1 NUG1 PWP2 RPL15B RPL27A RPN2 UTP15 YBL028C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CIC1 and NOP56 Huh WK, et al. (2003)
    View Data CIC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130]
    [219..311]    		 PSI-BLAST 54.69897 70S ribosome functional complex
    2 View Details [131..218] PSI-BLAST 54.69897 70S ribosome functional complex
    3 View Details [312..376] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle