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Protein Overview: GBP2

General Information:
Name(s) found: GBP2 / YCL011C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 427 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: telomere maintenance [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    poly(A)+ mRNA export from nucleus [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]
    telomeric DNA binding [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [NCBI BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERELGMYGN DRSRSRSPVR RRLSDDRDRY DDYNDSSSNN GNGSRRQRRD RGSRFNDRYD  60
   61 QSYGGSRYHD DRNWPPRRGG RGRGGSRSFR GGRGGGRGRT LGPIVERDLE RQFDATKRNF 120
  121 ENSIFVRNLT FDCTPEDLKE LFGTVGEVVE ADIITSKGHH RGMGTVEFTK NESVQDAISK 180
  181 FDGALFMDRK LMVRQDNPPP EAAKEFSKKA TREEIDNGFE VFIINLPYSM NWQSLKDMFK 240
  241 ECGHVLRADV ELDFNGFSRG FGSVIYPTED EMIRAIDTFN GMEVEGRVLE VREGRFNKRK 300
  301 NNDRYNQRRE DLEDTRGTEP GLAQDAAVHI DETAAKFTEG VNPGGDRNCF IYCSNLPFST 360
  361 ARSDLFDLFG PIGKINNAEL KPQENGQPTG VAVVEYENLV DADFCIQKLN NYNYGGCSLQ 420
  421 ISYARRD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) Manuscript in preparation. ASC1 CTK1 GBP2 HPR1 KEM1 MFT1 PRP43 RPS11B, RPS11A RPS13 RPS24A, RPS24B RPS8A, RPS8B RPS9A RPS9B SBP1 SRO9 STO1 SUB2 TEX1 THO2 THP2 TIF4632 YRA1
    View Details Krogan NJ, et al. (2006) CPR7 GBP2 GVP36 HHO1 HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2 ULS1 YNL140C
    View Details Gavin AC, et al. (2006) GBP2 THP2
    View Details Ho Y, et al. (2002) CBF5 CBP2 CCM1 CDC33 CDC37 CIC1 CTK1 DBP7 ENP2 GBP2 HAS1 HHF2, HHF1 HMO1 HPR1 HRB1 HTB2 IMD1 IMD3 ISA1 KRE33 KRI1 MFT1 MGM101 MSS116 NOC2 NOP12 NOP6 NPL3 PET127 POL5 PRP43 PUF6 PWP1 RLI1 RRP12 RRP5 SFP1 SIT4 SUB2 TEX1 THO2 THP2 TIF4631 TRA1 TSR1 URB1 URB2 UTP10 UTP20 YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) GBP2 NPL3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GBP2 MOB2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GBP2 Huh WK, et al. (2003)
    [View in YRC Public Image Repository] (1 experiment(s)and 3 images)

    Protein Structure Data


    [What does the above image mean?] [View Top Sequence Alignments]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] PSI-BLAST 107.0 Poly(A)-binding protein
    2 View Details [113..210] PSI-BLAST 107.0 Poly(A)-binding protein
    3 View Details [211..329] PSI-BLAST 116.045757 Hu antigen D (Hud)
    4 View Details [330..427] PSI-BLAST 16.39794 Neural RNA-binding protein Musashi-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
    		• 4.08350076268185 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • structural molecule activity
    		•  2.78501986457503 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  2.47215943693079 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.04976561275235 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.92450390013691 bayes_pls_golite062009
  • DNA binding
    		•  1.8021593476478 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15127506309683 bayes_pls_golite062009
  • snRNA binding
    		•  1.12690941758278 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.43716526938634 bayes_pls_golite062009
  • transporter activity
    		•  0.417047632648771 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.288804044686487 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.2202184446161 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00171911393626201 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
    		• 4.08350076268185 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • structural molecule activity
    		•  2.78501986457503 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  2.47215943693079 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.04976561275235 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.92450390013691 bayes_pls_golite062009
  • DNA binding
    		•  1.8021593476478 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15127506309683 bayes_pls_golite062009
  • snRNA binding
    		•  1.12690941758278 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.43716526938634 bayes_pls_golite062009
  • transporter activity
    		•  0.417047632648771 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.288804044686487 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.2202184446161 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00171911393626201 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by:     Michael Riffle