YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: IMD3

General Information:
Name(s) found: IMD3 / YLR432W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 523 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: GTP biosynthetic process [TASLink to PubMed article]
    Molecular Function: IMP dehydrogenase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVRDYKTA LEFAKSLPRL DGLSVQELMD SKTRGGLTYN DFLVLPGLVD FPSSEVSLQT  60
   61 KLTRNITLNT PFVSSPMDTV TESEMAIFMA LLGGIGFIHH NCTPEDQADM VRRVKNYENG 120
  121 FINNPIVISP TTTVGEAKSM KERFGFSGFP VTEDGKRNGK LMGIVTSRDI QFVEDNSLLV 180
  181 QDVMTKNPVT GAQGITLSEG NEILKKIKKG KLLIVDDNGN LVSMLSRTDL MKNQNYPLAS 240
  241 KSATTKQLLC GAAIGTIDAD KERLRLLVEA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 300
  301 LEIIAGNVAT REQAANLIAA GADGLRIGMG SGSICITQEV MACGRPQGTA VYNVCEFANQ 360
  361 FGIPCMADGG VQNIGHITKA LALGSSTVMM GGMLAGTTES PGEYFYQDGK RLKAYRGMGS 420
  421 IDAMQKTGTK GNASTSRYFS ESDSVLVAQG VSGAVVDKGS IKKFIPYLYN GLQHSCQDIG 480
  481 YKSLTLLKEN VQSGKVRFEF RTASAQLEGG VHNLHSYEKR LHN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FUN12 IMD1 IMD2 IMD3 IMD4 KEM1 KRE33 NOP12 PUF6 RPF2 RPL10 RPL11B RPL15A RPL18A, RPL18B RPL20B RPL4B RPL5 RPL9B RPP0 RPS1B RPS2 RPS3 RPS4B, RPS4A RPS6A, RPS6B RRP5 STM1 UTP22 YAR075W
    View Details Krogan NJ, et al. (2006) COX18 IMD1 IMD2 IMD3 IMD4 PDE2 YAR075W
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 AI1 AIM46 AIR1 AIR2 ALA1 APE2 ARA1 ARE1 BAT1 CBF5 CBP2 CCM1 CDC10 CDC33 CIC1 CKA1 CKA2 CKB1 CLU1 CYS3 DBP7 DED81 DPS1 DRS1 EBP2 ELA1 ENP2 ERG10 ERG20 ESF1 ESF2 FET4 FUN12 GBP2 GCY1 GPH1 GRS1 HAS1 HHO1 HMO1 HOM2 HPR1 HTB1 HTB2 HYP2 ILS1 IMD1 IMD2 IMD3 IMD4 ISA1 KRE33 KRI1 KRS1 LAA1 LHP1 LSP1 MAG1 MAG2 MDH3 MFT1 MGM101 MPH1 MSC3 MSH2 MSS116 MTR4 NAP1 NOC2 NOG1 NOP1 NOP12 NOP13 NOP4 NOP53 NOP56 NOP6 NOP7 NPL3 OLA1 OYE2 PAB1 PAP2 PDC6 PET127 PFK2 PGM2 PMA1 PMI40 POL5 PRP43 PRP6 PSE1 PUF6 PWP1 RET1 RLI1 RPC82 RPF2 RRP12 RRP5 SAC6 SCP160 SOD1 SSZ1 SUB2 TEX1 THO2 THP2 THR4 TIF4631 TIF4632 TIS11 TRA1 TRR1 TSR1 UBA1 URB1 URB2 UTP10 UTP20 UTP22 YCR087W YDL124W YDR102C YER077C YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) IMD3 RPL4B

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run HSL7 No Comments McCusker D, et al (2007)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IMD3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..523] PSI-BLAST 10149.0 Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • IMP dehydrogenase activity
    		•  2.02048863053452 bayes_pls_golite062009
  • binding
    		•  0.964202692685807 bayes_pls_golite062009
  • transporter activity
    		•  0.961062314616209 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.807029018941177 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.640881170978843 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.525366315833255 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.440262824681055 bayes_pls_golite062009
  • protein binding
    		•  0.22179604283012 bayes_pls_golite062009
  • catalytic activity
    		•  0.181756622780318 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.0973526732376297 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle