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Protein Overview: LAA1

General Information:
Name(s) found: LAA1 / YJL207C [SGD]
Description(s) found:
Found 28 descriptions.
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  • AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2014 amino acids

    Gene Ontology:
    Cellular Component: AP-1 adaptor complex [IPILink to PubMed article]
    ribosome [IDALink to PubMed article]
    clathrin-coated vesicle [IDALink to PubMed article]
    Biological Process: protein localization [IMPLink to PubMed article]
    retrograde transport, endosome to Golgi [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANRSLKKVI ETSSNNGHDL LTWITTNLEK LICLKEVNDN EIQEVKEIHT QLDEFVRYIS  60
   61 VLENTDDLEL HSVFISLSQL YTISIWRLKD EYPGVVFDSA AFLTNVLCEE DVSIDDGDTD 120
  121 PNQKKKKKKS STKKKKYIYS PAKDIACTIL VQLFENFGSS ISSLIPLLFN AIFKNLKKIM 180
  181 EKSKYYHATF MTTLLQLFNA ILRNSNNDDK ILDPATYAKF SKLSKTVFDS ISTDEKDFSV 240
  241 TFVSVLIECW TAHFKQTNFI REHSHDIIET IYSRFTEGEI GVYGFANDET RIFTAKSLAE 300
  301 ILFDYYFSKN ILTLQEVWSI YVKIFLNCDT RDVESGCFES IIHLINLNLL ADNTFLSNSK 360
  361 YLDIVLSLSG VFSSYEVNNR SMNTLSRYLR YFQHMHEVIL PHLNDSAKTQ MLYYILGCSD 420
  421 TYQSSSKSDS ASNFKYSIDA KPETQWLTLL QLDFTYVLIS DLGSTFTTEE NTVKEIRDKL 480
  481 VDLATCEIFT IRVHTVEILK VFLNNCPEYL SETIENSLRA LSTDFKSTGK FIFHKNHGHA 540
  541 FIIANLIKGA ESDYISYELI MRITVFSTSF IKNNTTSTSS NLYFKGLLCW ILLIGLMNYK 600
  601 DEQYLKLQIP QLFLFWKVLL THTYTYHDED ELYKNLEIRN HALTCLLTYL SNTTIDKEMA 660
  661 KQVSYLLTKC SNFNHSIDLK SKNIDNALLH NENRILQVYL KLEKYINSDF NSSLLILIVK 720
  721 NFSDPNLYTE SSSSVLGSLK DIGNRKVSNK DDMESNIVLE SSINTLLRQN NGFAFGLSSK 780
  781 ITGDRIVNLS MSSAYKYDES ISGSWPSKDY NWYNIFEVEV SKPISPILSL DSLILLYGSG 840
  841 SYSQIDRYAP QVTTSLIDSS MELFSSVFPF LNSKIQYSIM ETLNLSMFSK MTTPLRSVAV 900
  901 AANVCSALHN ALRIMQENNL ELDYSVGQLI IESIKKIQFF NDIFLTKIKA DCVGLLTAAI 960
  961 ARTLGDEERQ KFLTEQSRIF IKNVADMDEP YLRMFHVLSL ATIFKYNSQY ANFEEYFDVI1020
 1021 FALMRDPHPV VHSWSLKAMH ILLEKHLVID LKTAALLLSS MEELLVQDKY GIYGRSTLRC1080
 1081 NYNRDFNSHV AIGEISRTLT ETVGPNFLEL NTKVLDSFRN ITLSMLISNN ILNSITSIKM1140
 1141 FENIATFKMK NILNYEIFIL ASKSIIKSSI VTGIGSSYFD TTFTGSNELI SRTSSLKGAF1200
 1201 ENFDLLTLLY KLQMEEFFMK EMENLSWRYL ALFPNSGSVK NYFTEWILHT FKRDNHWFDK1260
 1261 LYSIFNMSLG RLFQSYNRDV SALLEVNGLK KSSEKEIKGE EEESIANVNQ LTDTDAGGLD1320
 1321 SENLQWKSRQ IILNLILMLC LESEKYENLL LALSNKIADL IKISFRGSTV RNEGMKLTGL1380
 1381 HILNFVLKNY STMRDPQVPG SSILEQQEAQ ITSALMPAFS KGSSPTVMSF AITVAAEVLA1440
 1441 SNIMPPDKLG RISQLLIDLL GNFKDPNSGI RIGEAIIVTP KAKRKIELAV LDAWAEVVQR1500
 1501 SITSSNDALF SFTRKYWSIL VPLWIISLRE YMMIKYNDND STVQVKNDSK ENSLIEPRST1560
 1561 KIELYEPVWL NFVEALGCTL DSDVQVILAS LNDEELEYFL FILFSQCLEA IVKNIDDHSV1620
 1621 KMQVLPALHN VLKSNLCIKS IFEDDIITEV VEIMDRLIST GDSKEEFLLV DIISDLIIGY1680
 1681 SKCNATPETF LQDIDKLYEL LRLLMTIISE RLPFIKYNVL TSEEDDNEIK ISPTDISLLK1740
 1741 KTFIAFESNI SNFDNMFKVD LYSCLLFIIG KIYECSHREV IIPIILPLFK ALVKALTESE1800
 1801 DEKNIVLLEI FYGSIKDVIY HKLDSKNKVA TILILLSNGY SKLSFQELNQ CANILSEALN1860
 1861 NPATQPIALQ GFKRIISNIF KYPLLQYFMK LVIKRFFQDI QTNDSLSQAS IKTKLIIQFS1920
 1921 EEVIKQDHQK ASLSIALCLS FFAAYHSAYT EKIDNEVASG IVALAKLDKN SFKEAISSTI1980
 1981 SPQQKAIIGS VMEAYVKSQS LGSVEEAFQL KSFD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C
    View Details Ho Y, et al. (2002) BCY1 CAR2 CDC33 CKA1 CKA2 CKB1 CYS4 ESF1 ESF2 GND1 GTO1 HTB1 IMD3 LAA1 LHP1 LYS1 MSS116 NOP12 PMA1 RPF2 SAH1 SNO2 SSN8 THI22 THO2 TIF1, TIF2 TPK2 TPK3 VPS21 YBR028C YCK1 YCK2 YCK3 YCR087W YDR102C YGR111W YPT53 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run STU1 No Comments Cheeseman IM, et al. (2002)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LAA1 Huh WK, et al. (2003)
    View Data LAA1 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1286] deduced N/A No confident structure predictions are available.
    2 View Details [1287..1473] MSA 1.007958 View MSA. No confident structure predictions are available.
    3 View Details [1474..1838] MSA 1.009949 View MSA. No confident structure predictions are available.
    4 View Details [1839..2014] deduced N/A No confident structure predictions are available.
    5 View Details [551..780] deduced N/A No confident structure predictions are available.
    6 View Details [781..842] deduced N/A No confident structure predictions are available.
    7 View Details [843..1554] FFAS03 1.19 Adaptin beta subunit N-terminal fragment
    8 View Details [1555..1684] MSA 2.05697 View MSA. No confident structure predictions are available.
    9 View Details [1685..1802] deduced N/A No confident structure predictions are available.
    10 View Details [1803..1881] deduced N/A No confident structure predictions are available.
    11 View Details [1882..2014] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • clathrin binding
    		•  4.44172446279719 bayes_pls_golite062009
  • protein transporter activity
    		•  3.8871835220517 bayes_pls_golite062009
  • transporter activity
    		•  2.3766833486706 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.12926593993985 bayes_pls_golite062009
  • binding
    		•  2.08129940242136 bayes_pls_golite062009
  • protein binding
    		•  2.0097220759196 bayes_pls_golite062009
  • structural molecule activity
    		•  1.70115473462412 bayes_pls_golite062009
  • signal sequence binding
    		•  1.53212344797955 bayes_pls_golite062009
  • RNA binding
    		•  1.423416093612 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.2724388835449 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.04982314606251 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.824035252349223 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260663498540354 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.256036243669218 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.234271600707329 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.225395946682209 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.186601655036333 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.183072614802483 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.182751938544977 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.15186105020367 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.109435859778099 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0728493557966827 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0641324729536009 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0615190129942244 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0475280280823402 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle