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Protein Overview: ADE6

General Information:
Name(s) found: ADE6 / YGR061C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1358 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: purine nucleotide biosynthetic process [IMPLink to PubMed article][TAS]
    'de novo' IMP biosynthetic process [TAS]
    Molecular Function: phosphoribosylformylglycinamidine synthase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDYILPGPK ALSQFRVDNL IKDINSYTNS TSVINELRSC YIHYVNGIAQ NLSEQDTKLL  60
   61 EVLLTYDSAL DIANDPLARQ LNDAVANNLP SSALGEDTYL IRVVPRSGTI SPWSSKATNI 120
  121 AHVCGLQDKV QRIERGLALL IKTVPGFPLL ENLNDISLKC VYDRMTQQLY LTEPPNTMSI 180
  181 FTHEEPKPLV HVPLTPKDTK QSPKDILSKA NTELGLALDS GEMEYLIHAF VETMKRDPTD 240
  241 VELFMFAQVN SEHCRHKIFN ADWTIDGIKQ QFTLFQMIRN THKLNPEYTI SAYSDNAAVL 300
  301 DSENDAFFFA PNSTTKEWTS TKERIPLLIK VETHNHPTAV SPFPGAATGS GGEIRDEGAT 360
  361 GRGSKTKCGL SGFSVSDLLI PGNEQPWELN IGKPYHIASA LDIMIEAPLG SAAFNNEFGR 420
  421 PCINGYFRTL TTKVLNHQGK EEIRGFHKPI MIAGGFGTVR PQFALKNTPI TPGSCLIVLG 480
  481 GQSMLIGLGG GAASSVASGE GSADLDFASV QRGNPEMERR CQQVIDACVA LGNNNPIQSI 540
  541 HDVGAGGLSN ALPELVHDND LGAKFDIRKV LSLEPGMSPM EIWCNESQER YVLGVSPQDL 600
  601 SIFEEICKRE RAPFAVVGHA TAEQKLIVED PLLKTTPIDL EMPILFGKPP KMSRETITEA 660
  661 LNLPEANLSE IPSLQDAIQR VLNLPSVGSK SFLITIGDRS VTGLIDRDQF VGPWQVPVAD 720
  721 VGVTGTSLGE TIISTGEAMA MGEKPVNALI SASASAKLSV AESLLNIFAA DVKSLNHIKL 780
  781 SANWMSPASH QGEGSKLYEA VQALGLDLCP ALGVAIPVGK DSMSMKMKWD DKEVTAPLSL 840
  841 NITAFAPVFN TSKTWTPLLN RNTDDSVLVL VDLSAKQETK SLGASALLQV YNQVGNKSPT 900
  901 VYDNAILKGF LESLIQLHQQ KEDIVLAYHD RSDGGLLITL LEMAFASRCG LEINIDGGDL 960
  961 ESQLTNLFNE ELGAVFQISA KNLSKFEKIL NENGVAKEYI SIVGKPSFQS QEIKIINSTT1020
 1021 NDVIYANSRS ELEQTWSKTS YEMQKLRDNP KTAEEEFASI TDDRDPGLQY ALTYNPADDM1080
 1081 KIGLELSSQR PKVAILREQG VNGQMEMAWC FQQAGFNSVD VTMTDLLEGR FHLDDFIGLA1140
 1141 ACGGFSYGDV LGAGAGWAKS VLYHEGVRSQ FSKFFNERQD TFAFGACNGC QFLSRLKDII1200
 1201 PGCENWPSFE RNVSEQYEAR VCMVQISQEK DNSSEESVFL NGMAGSKLPI AVAHGEGKAT1260
 1261 FSKSAEQLEK FEKDGLCCIR YVDNYGNVTE RFPFNPNGST NGIAGIKSPN GRVLAMMPHP1320
 1321 ERVCRLEANS WYPEGKYEEW GGYGPWIRLF RSARRWVG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE6 BUL1 LDB19 RSP5 RUP1 UBP2 YHR131C
    View Details Gavin AC, et al. (2006) ADE6 PET123 RSM23
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 BAT1 CDC10 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH3 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SOD1 SSZ1 THR4 TRR1 UBA1 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ADE6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..251] deduced N/A No confident structure predictions are available.
    2 View Details [252..463] PSI-BLAST 66.39794 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
    3 View Details [464..484]
    [527..655]    		 PSI-BLAST 66.39794 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
    4 View Details [485..526] PSI-BLAST 66.39794 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain; Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
    5 View Details [656..1062] MSA 32.13098 View MSA. No confident structure predictions are available.
    6 View Details [1063..1358] PSI-BLAST 10.69897 Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF; GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoribosylformylglycinamidine synthase activity
    		•  3.63602541423478 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine cyclo-ligase activity
    		•  3.04322905277855 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  2.83262699406158 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.47010130088456 bayes_pls_golite062009
  • cyclo-ligase activity
    		•  2.40623349460413 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  1.74828881793189 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  1.74029540439985 bayes_pls_golite062009
  • binding
    		•  1.31749052462602 bayes_pls_golite062009
  • catalytic activity
    		•  1.23634637968745 bayes_pls_golite062009
  • ligase activity
    		•  1.09859780971947 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.78656048097577 bayes_pls_golite062009
  • protein binding
    		•  0.288540446972424 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.12569720972861 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle