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Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. Catalysis of a reaction that results in the formation of carbamoyl phosphate. Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Acc: GO:0004088
Aspect: Molecular Function
Desc: Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
Synonyms:
  • carbamoylphosphate synthetase II activity
  • carbamoyl-phosphate synthase (glutamine-hydrolysing) activity
  • carbamoyl phosphate synthase (glutamine-hydrolyzing) activity
  • carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
  • carbamoyl phosphate synthetase activity
  • carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity
  • glutamine-dependent carbamoyl-phosphate synthase activity
  • hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
  • CPS activity
  • carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity
  • carbamyl phosphate synthetase (glutamine) activity
  • GD-CPSase activity
  • glutamine-dependent carbamyl phosphate synthetase activity
Proteins in PDR annotated with:
   This term: 43 [Search]
   Term or descendants: 43 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (interactive image map)
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