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Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate. Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphoribosylformylglycinamidine synthase activity
Acc: GO:0004642
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate.
Synonyms:
  • FGAM synthetase activity
  • formylglycinamide ribotide amidotransferase activity
  • 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
  • FGAM synthase activity
  • N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
  • phosphoribosylformylglycinamidine synthetase activity
  • 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)
  • FGAR amidotransferase activity
  • formylglycinamide ribonucloetide amidotransferase activity
  • phosphoribosylformylglycineamidine synthetase activity
  • FGARAT activity
Proteins in PDR annotated with:
   This term: 41 [Search]
   Term or descendants: 41 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004642 - phosphoribosylformylglycinamidine synthase activity (interactive image map)
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