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Protein Overview: RRP5

General Information:
Name(s) found: RRP5 / YMR229C [SGD]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1729 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [IPILink to PubMed article]
    nucleolus [TASLink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [TASLink to PubMed article]
    Molecular Function: RNA binding [TASLink to PubMed article]
    snoRNA binding [IPILink to PubMed article]
    rRNA primary transcript binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVASTKRKRD EDFPLSREDS TKQPSTSSLV RNTEEVSFPR GGASALTPLE LKQVANEAAS  60
   61 DVLFGNESVK ASEPASRPLK KKKTTKKSTS KDSEASSANS DEARAGLIEH VNFKTLKNGS 120
  121 SLLGQISAIT KQDLCITFTD GISGYVNLTH ISEEFTSILE DLDEDMDSDT DAADEKKSKV 180
  181 EDAEYESSDD EDEKLDKSNE LPNLRRYFHI GQWLRCSVIK NTSLEPSTKK SKKKRIELTI 240
  241 EPSSVNIYAD EDLVKSTSIQ CAVKSIEDHG ATLDVGLPGF TGFIAKKDFG NFEKLLPGAV 300
  301 FLGNITKKSD RSIVVNTDFS DKKNKITQIS SIDAIIPGQI VDLLCESITK NGIAGKVFGL 360
  361 VSGVVNVSHL RTFSEEDLKH KFVIGSSIRC RIIACLENKS GDKVLILSNL PHILKLEDAL 420
  421 RSTEGLDAFP IGYTFESCSI KGRDSEYLYL ALDDDRLGKV HSSRVGEIEN SENLSSRVLG 480
  481 YSPVDDIYQL STDPKYLKLK YLRTNDIPIG ELLPSCEITS VSSSGIELKI FNGQFKASVP 540
  541 PLHISDTRLV YPERKFKIGS KVKGRVISVN SRGNVHVTLK KSLVNIEDNE LPLVSTYENA 600
  601 KNIKEKNEKT LATIQVFKPN GCIISFFGGL SGFLPNSEIS EVFVKRPEEH LRLGQTVIVK 660
  661 LLDVDADRRR IIATCKVSNE QAAQQKDTIE NIVPGRTIIT VHVIEKTKDS VIVEIPDVGL 720
  721 RGVIYVGHLS DSRIEQNRAQ LKKLRIGTEL TGLVIDKDTR TRVFNMSLKS SLIKDAKKET 780
  781 LPLTYDDVKD LNKDVPMHAY IKSISDKGLF VAFNGKFIGL VLPSYAVDSR DIDISKAFYI 840
  841 NQSVTVYLLR TDDKNQKFLL SLKAPKVKEE KKKVESNIED PVDSSIKSWD DLSIGSIVKA 900
  901 KIKSVKKNQL NVILAANLHG RVDIAEVFDT YEEITDKKQP LSNYKKDDVI KVKIIGNHDV 960
  961 KSHKFLPITH KISKASVLEL SMKPSELKSK EVHTKSLEEI NIGQELTGFV NNSSGNHLWL1020
 1021 TISPVLKARI SLLDLADNDS NFSENIESVF PLGSALQVKV ASIDREHGFV NAIGKSHVDI1080
 1081 NMSTIKVGDE LPGRVLKIAE KYVLLDLGNK VTGISFITDA LNDFSLTLKE AFEDKINNVI1140
 1141 PTTVLSVDEQ NKKIELSLRP ATAKTRSIKS HEDLKQGEIV DGIVKNVNDK GIFVYLSRKV1200
 1201 EAFVPVSKLS DSYLKEWKKF YKPMQYVLGK VVTCDEDSRI SLTLRESEIN GDLKVLKTYS1260
 1261 DIKAGDVFEG TIKSVTDFGV FVKLDNTVNV TGLAHITEIA DKKPEDLSAL FGVGDRVKAI1320
 1321 VLKTNPEKKQ ISLSLKASHF SKEAELASTT TTTTTVDQLE KEDEDEVMAD AGFNDSDSES1380
 1381 DIGDQNTEVA DRKPETSSDG LSLSAGFDWT ASILDQAQEE EESDQDQEDF TENKKHKHKR1440
 1441 RKENVVQDKT IDINTRAPES VADFERLLIG NPNSSVVWMN YMAFQLQLSE IEKARELAER1500
 1501 ALKTINFREE AEKLNIWIAM LNLENTFGTE ETLEEVFSRA CQYMDSYTIH TKLLGIYEIS1560
 1561 EKFDKAAELF KATAKKFGGE KVSIWVSWGD FLISHNEEQE ARTILGNALK ALPKRNHIEV1620
 1621 VRKFAQLEFA KGDPERGRSL FEGLVADAPK RIDLWNVYVD QEVKAKDKKK VEDLFERIIT1680
 1681 KKITRKQAKF FFNKWLQFEE SEGDEKTIEY VKAKATEYVA SHESQKADE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATP22 BRX1 GAR1 GIN4 IMD3 KRI1 LOC1 MAK21 NOC2 NOP12 NOP2 NOP56 NOP58 RPF2 RPL11B RPL16A RPL18A, RPL18B RPL1A, RPL1B RPL5 RRP5 UTP22
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Ho Y, et al. (2002) CBF5 CBP2 CCM1 CDC33 CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 DBP7 DIP2 DRS1 EBP2 ENP2 ERB1 ESL2 FET4 GBP2 GDE1 HAS1 HHF1, HHF2 HMO1 HOT1 HTB2 IMD1 IMD2 IMD3 ISA1 KRE33 KRI1 LCP5 MAM33 MGM101 MRPL1 MSS116 NAN1 NOC2 NOC3 NOP1 NOP12 NOP13 NOP2 NOP56 NOP6 NOP7 NPL3 NUG1 PDI1 PET127 PNO1 POB3 POL2 POL5 PRP40 PRP43 PTC5 PTP3 PUF6 PWP1 PWP2 RHO2 RLI1 RPF2 RRP1 RRP12 RRP14 RRP15 RRP5 SFP1 SOF1 SPB1 SPT16 SRP1 SSF1 TFP1 TIF4631 TIF6 TRA1 TRL1 TSR1 URB1 URB2 UTP10 UTP11 UTP13 UTP14 UTP18 UTP20 UTP21 UTP22 UTP30 UTP6 VMR1 VPS73 WTM2 YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) BRX1 BUD21 DIP2 DRS1 ENP1 GAR1 IMP4 MRD1 NAN1 NHP2 NSR1 NUG1 PWP2 RKI1 RPL10 RPL12B, RPL12A RPL13A RPL14B RPL17B RPL20A RPL20B RPL21A RPL21B RPL24A RPL24B RPL25 RPL26A RPL29 RPL2A, RPL2B RPL30 RPL31A RPL32 RPL33B RPL34A RPL35A, RPL35B RPL37A RPL38 RPL39 RPL43B, RPL43A RPP2A RPS12 RPS14B RPS15 RPS16B, RPS16A RPS17A RPS18B, RPS18A RPS19B RPS1A RPS1B RPS2 RPS22A RPS7A RPS7B RRP3 RRP5 RRP9 SAS10 SOF1 TIF6 TSR1 UTP10 UTP11 UTP13 UTP14 UTP15 UTP20 UTP22 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RRP5 and NOP56 Huh WK, et al. (2003)
    View Data RRP5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] deduced N/A No confident structure predictions are available.
    2 View Details [70..231] MSA 2.042991 View MSA. No confident structure predictions are available.
    3 View Details [232..295] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [296..454] MSA 1.105996 View MSA. No confident structure predictions are available.
    5 View Details [455..550] deduced N/A No confident structure predictions are available.
    6 View Details [551..689] PSI-BLAST 56.522879 S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase
    7 View Details [690..785]
    [858..880]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    8 View Details [786..857]
    [881..943]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    9 View Details [944..966]
    [1097..1175]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    10 View Details [967..1096]
    [1176..1369]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    11 View Details [1370..1528] PSI-BLAST 23.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    12 View Details [1529..1596] PSI-BLAST 23.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    13 View Details [1597..1729] PSI-BLAST 23.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of ribosome
    		•  5.1118741250402 bayes_pls_golite062009
  • structural molecule activity
    		•  4.51553901145182 bayes_pls_golite062009
  • nuclease activity
    		•  3.11657409772275 bayes_pls_golite062009
    		• 3.02322635335914 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.66669472409706 bayes_pls_golite062009
  • exoribonuclease activity
    		•  2.4082195258205 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  2.3619669410791 bayes_pls_golite062009
  • RNA binding
    		•  2.33019817554364 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.12039058720352 bayes_pls_golite062009
  • exonuclease activity
    		•  1.87925169250843 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.74431545836806 bayes_pls_golite062009
  • translation regulator activity
    		•  1.66546288751201 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.61238850131825 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.59628511603826 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.44123900197846 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.19753926150484 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.12235348738959 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10433412699603 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.07288786419238 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.07285050275461 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.07285050275461 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  1.05238432657007 bayes_pls_golite062009
  • endonuclease activity
    		•  0.991569665925888 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.95191912850966 bayes_pls_golite062009
  • binding
    		•  0.762139256580538 bayes_pls_golite062009
  • DNA binding
    		•  0.710663468386339 bayes_pls_golite062009
  • translation elongation factor activity
    		•  0.55678032558705 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.52627345520111 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • transcription factor activity
    		•  0.332903382446869 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.21650406007586 bayes_pls_golite062009
  • ligase activity
    		•  0.148928528645156 bayes_pls_golite062009
  • mRNA binding
    		•  0.10617671731447 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.07404631453071 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009
    2
    Term Confidence Notes
  • structural constituent of ribosome
    		•  5.22538452462352 bayes_pls_golite062009
  • structural molecule activity
    		•  4.65301390020308 bayes_pls_golite062009
  • RNA binding
    		•  3.36396086314433 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.24341202600661 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.16830676862423 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.94887328847363 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.90081280972069 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.53286219413126 bayes_pls_golite062009
    		• 1.49823328757628 bayes_pls_golite062009
  • binding
    		•  1.38311294671926 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.31550811238109 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.07288786419238 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.07285050275461 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.07285050275461 bayes_pls_golite062009
  • transcription termination factor activity
    		•  1.01993495617192 bayes_pls_golite062009
  • DNA binding
    		•  0.86484629764139 bayes_pls_golite062009
  • mRNA binding
    		•  0.650019633484614 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.477960254167 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • tRNA-specific ribonuclease activity
    		•  0.383567539949931 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • protein binding
    		•  0.292595239533272 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.1757578095579 bayes_pls_golite062009
  • ligase activity
    		•  0.148928528645156 bayes_pls_golite062009
  • catalytic activity
    		•  0.10089766806364 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.12690485191789 bayes_pls_golite062009
  • RNA binding
    		•  2.0770703064779 bayes_pls_golite062009
  • protein binding
    		•  1.39668540998298 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.26149030245805 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.01193875360949 bayes_pls_golite062009
  • DNA binding
    		•  0.80346414607277 bayes_pls_golite062009
  • transcription factor activity
    		•  0.374364600772076 bayes_pls_golite062009
  • signal sequence binding
    		•  0.0529781042891342 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle