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Protein Overview: NAN1

General Information:
Name(s) found: NAN1 / YPL126W [SGD]
Description(s) found:
Found 23 descriptions.
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  • U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 896 amino acids

    Gene Ontology:
    Cellular Component: RENT complex [IPILink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article][IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: snoRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQSLGIEQY KLSVVSGGKP ALNNLSSVTG NKNIARLSQD QRNYIIPFNN QIKVYSVETR  60
   61 QCVKTLKFAN NSLLSGIFLQ EEENNESIVK ILLGDITVPQ QEDAHLITVF TNNGHVIVLN 120
  121 YKGKLVESPK HFKISLADEK LANVFHSEGN YRILTTFKDP SQKAHNSLQS YRLYALTFDD 180
  181 AKKQFEVAHQ AEWHNVILSN ISSNGKLLAH MCKDVSTKDH EHKSISVVSL FDDSVNLSFP 240
  241 LGSILSSQTQ SLSYNTRYVS SMAIDNMGQQ LAVGFASGVI SIVSLADLQI RLLKWHIDSV 300
  301 LSLSFSHDGS YLLSGGWEKV MSLWQLETNS QQFLPRLNGI IIDCQVLGPQ GNYYSLILQM 360
  361 TENNSNSDYQ FLLLNASDLT SKLSINGPLP VFNSTIKHIQ QPISAMNTKN SNSITSLNHS 420
  421 KKKQSRKLIK SRRQDFTTNV EINPINKNLY FPHISAVQIF DFYKNEQVNY QYLTSGVNNS 480
  481 MGKVRFELNL QDPIITDLKF TKDGQWMITY EIEYPPNDLL SSKDLTHILK FWTKNDNETN 540
  541 WNLKTKVINP HGISVPITKI LPSPRSVNNS QGCLTADNNG GLKFWSFDSH ESNWCLKKIS 600
  601 LPNFNHFSNS VSLAWSQDGS LIFHGFDDKL QILDFDTFKK FESLENTKTV SEFTLDSEIQ 660
  661 TVKLINDTNL IVATRTTLNA INLLRGQVIN SFDLYPFVNG VYKNGHMDRL ITCDERTGNI 720
  721 ALVINQQLTD LDGVPTINYK SRIIIFDSDL STKLGNFTHH EYISWIGWNY DTDFIFLDIE 780
  781 STLGVVGTTV NTQLSDEVNN EGILDGLVSN TITTSASNSD IFAEQLHKLS SRGKKSDTRD 840
  841 KNTNDNDEDE EDIALEFING EKKDKLVNMN SFTSMFDNIQ NVQMDTFFDR VMKVLT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 DIM1 DIP2 ECM16 EMG1 ENP1 ENP2 IMP3 KRE33 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 PNO1 POL5 PWP2 ROK1 RPS7A RRP12 RRP9 SOF1 UTP10 UTP13 UTP15 UTP20 UTP21 UTP22 UTP30 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9
    View Details Krogan NJ, et al. (2006) GFD2 NAN1 POL5 UTP10 UTP15 UTP4 UTP5 UTP8 UTP9
    View Details Gavin AC, et al. (2006) CDC60 CMS1 DIP2 MRD1 NAN1 NOP58 PNO1 PWP2 ROK1 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Gavin AC, et al. (2002) ACT1 ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENO2 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 FPR4 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 POL5 PRE6 PRE9 PRP43 PTA1 PTI1 PWP1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SMC1 SOF1 SRO9 TIF1, TIF2 TSR1 TYW1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Ho Y, et al. (2002) ADK1 BRX1 BUD3 CCT2 CCT3 CCT6 CIN8 CKA1 CKA2 CKB1 CKB2 CLU1 COP1 DIP2 ESL2 GND1 GND2 GPH1 HIR1 HSP104 HTB1 KGD1 KRE33 LCP5 MNP1 NAN1 NOP1 NOP56 PFK1 PNO1 POL5 PRP11 PRP40 PTC5 PWP2 REX2 RRP12 RRP5 RVB1 SAP1 SCS2 SEC27 SHM2 SSD1 SSK2 TFP1 THI22 TIF4631 TMA19 TPS2 UBP15 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 UTP7 UTP9 YGR250C
    View Details Qiu et al. (2008) DBP7 DBP8 DHR2 DIP2 ENP1 GAR1 HCA4 IMP3 KRR1 MAK11 MAK5 MRD1 NAN1 NET1 NOP12 NOP4 NSR1 PUF6 PWP2 RNT1 RRB1 RRP1 RRP5 RRP9 SAS10 SOF1 UTP10 UTP11 UTP13 UTP14 UTP15 UTP20 UTP21 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NAN1 and NOP56 Huh WK, et al. (2003)
    View Data NAN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..172] PSI-BLAST 38.522879 Cdc4 F-box and linker domains; Cdc4 propeller domain
    2 View Details [173..536] PSI-BLAST 56.69897 Tup1, C-terminal domain
    3 View Details [537..632] PSI-BLAST 58.0 beta1-subunit of the signal-transducing G protein heterotrimer
    4 View Details [633..896] PSI-BLAST 4.045757 Surface layer protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  1.90408871052739 bayes_pls_golite062009
  • protein binding
    		•  1.47118967208188 bayes_pls_golite062009
  • catalytic activity
    		•  0.233388920718075 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle