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Protein Overview: SSK2

General Information:
Name(s) found: SSK2 / YNR031C [SGD]
Description(s) found:
Found 28 descriptions.
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  • MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1579 amino acids

    Gene Ontology:
    Cellular Component: cellular bud tip [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: osmosensory signaling pathway [TASLink to PubMed article]
    response to osmotic stress [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    actin cytoskeleton organization [IDALink to PubMed article]
    activation of MAPKK activity involved in osmosensory signaling pathway [TASLink to PubMed article]
    Molecular Function: MAP kinase kinase kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHSDYFNYK PYGDSTEKPS SSKMRQSSSS SSSRLRSESL GRNSNTTQAR VASSPISPGL  60
   61 HSTQYFRSPN AVYSPGESPL NTVQLFNRLP GIPQGQFFHQ NAISGSSSSS ARSSRRPSNI 120
  121 GLPLPKNPQQ SLPKLSTQPV PVHKKVEASK TESEIIKKPA PVNSNQDPLL TTPTLVISPE 180
  181 LASLNTTNTS IMSTPQNITN QTSNKHIPTR SQPNGSTSSS TLQDIVTTNS SQRSVGHHGG 240
  241 STTSLRTYKK QYVLNEQLYL RKMRNRANDD YYTRGIVASS NFEDDEENFS NKGEDDLELE 300
  301 MDDLLKVEGE DKDNDFNFGY NFITSSTKNN ENVVSMSLNY LKGKLDWLRD VNNDQPCEIE 360
  361 DEEWHSILGS EDLLSKLLQN PMVNNRFEWQ TMLSKVLKGD IVRNEKTKIA NQGKGPGFNT 420
  421 QFSDDIWIEL KAWMNGRTVE DQNKSLRIFR DSTDSVFQEI MAFKLEDNMS ADEAAETIKS 480
  481 LVDKYYRVLN LWPNIKRMHA EKPITKTEAF RNRIDTLNSW LNFKFNFDTN IAYLKKWIVG 540
  541 NKELESTTEV DNTTVNLDDP AVFATNCKRF AEQIMKEKDI ELIFQKKIFF PLAPWILKAK 600
  601 FFFLKYQKTW NELNLSYLDQ DLEFLLMFPM RLVKDIILIR LSYAKKIQNP TLMMIDQMMD 660
  661 DFSTYIKLAV QMKFTVASYC NDWFFKVKID PEFDHTVVEG LEYFFSILEL RILYSGKNSF 720
  721 KTSKEPDLLL KYWEMFRNVG YYIDDAGELI AAEFTKLTLR LVHRLHAYLL RQQNTPPKLE 780
  781 NEAAAEKWLV QIFEILGSMK RKLNRFTNIL TKAFQNFVRY KIEDHNYLLK QLKETGHFLI 840
  841 YTGGYLEQNG TYLIGSPELL GCKDDDILRI IKNSDIGCDL VPKLEINNSL TIYNALDDNW 900
  901 NSNSSLGSDI SNDGTPFYYI KNDLTTQPRS YNGNRVNREP DFENSRSTEE EFYELETRLN 960
  961 SLGYVLVLTP QEPLLWEGEM YNLSDNKTIK PEGLNLKVIP NSIDLMCQGS SYALEYQCDR1020
 1021 FQQISGSSVS FLEKKSSSET VKNNLQRINK AYFRCTYSVL KNYTKIVTTF KKVSPVNDLL1080
 1081 NNIFLFGRDF GLNFLRINVA NNEKRSIIIL LMMRLSIGWL KFLAEDCDPT DQRVFRWCVT1140
 1141 SMEFAMHMVS GWNILALDEC QFSSLKQKIS ECMSLLISHF DIIGARSIEV EKINQQARSN1200
 1201 LDLEDVFDDD MMLQVNSEFR VQSIMELEER IKRNPHQTGK VIDDSDKGNK YLVSLASSIS1260
 1261 NVSMRWQKRN FIGGGTFGRV YSAVDLDNGE ILAVKEINIQ DSKSMQKIFP LIKEEMSVLE1320
 1321 ILNHPNIVSY YGVEVHRDKV NIFMEYCEGG SLAALLEHGR IEDEMVTQVY TLQLLEGLAY1380
 1381 LHESGIVHRD VKPENILLDF NGVIKYVDFG AAKKIANNGT RLASMNKIEN ADGEHEDVTH1440
 1441 VSDSKAVKNN ENALLDMMGT PMYMAPESIT GSTTKGKLGA DDVWSLGCVV LEMITGRRPW1500
 1501 ANLDNEWAIM YHVAAGHTPQ FPTKDEVSSA GMKFLERCLI QNPSKRASAV ELLMDPWIVQ1560
 1561 IREIAFGDDS SSTDTEERE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SSK1 SSK2
    View Details Krogan NJ, et al. (2006) SSK1 SSK2
    View Details Ho Y, et al. (2002) AAC3 ADK1 ARP4 ASA1 ATG17 ATG29 ATP3 CDC33 CIC1 CIS1 CLU1 COP1 CYS4 EST1 FAR1 FET4 FOL2 GPH1 GRH1 HAP2 HAP5 HPR1 IPP1 LOC1 MAM33 MTQ1 NAN1 NAP1 NMD5 NOP16 NSA2 PBS2 POL5 PRB1 PRP11 PSE1 PTP2 REX2 RHR2 RPT3 SAH1 SAP190 SEC27 SHM2 SLX5 SPE3 SRP1 SSK1 SSK2 SSK22 TFP1 THI22 THO2 TIF1, TIF2 TIF4631 TIF6 UBC7 UBP15 UTP13 YGR250C YRA1 YRA2 YTM1
    View Details Qiu et al. (2008) PKC1 SSK2 STE5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NSE4 SSK2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SSK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..560] deduced N/A No confident structure predictions are available.
    2 View Details [561..886] MSA 2.009916 View MSA. No confident structure predictions are available.
    3 View Details [887..1123] deduced N/A No confident structure predictions are available.
    4 View Details [1124..1256] PSI-BLAST 3.522879 Chk2 kinase
    5 View Details [1257..1346] PSI-BLAST 380.54902 pak1
    6 View Details [1347..1579] PSI-BLAST 380.54902 pak1
    7 View Details [934..1126] deduced N/A No confident structure predictions are available.
    8 View Details [1127..1204] PSI-BLAST 4.522879 Chk2 kinase
    9 View Details [1205..1579] PSI-BLAST 113.0 Crystal Structure of ROCK 1 bound to fasudil


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle