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Protein Overview: PTI1

General Information:
Name(s) found: PTI1 / YGR156W [SGD]
Description(s) found:
Found 33 descriptions.
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  • Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mRNA cleavage and polyadenylation specificity factor complex [IPILink to PubMed article]
    Biological Process: termination of RNA polymerase II transcription, poly(A)-coupled [IPILink to PubMed article]
    termination of RNA polymerase II transcription, poly(A)-independent [IMPLink to PubMed article][IPILink to PubMed article]
    mRNA polyadenylation [IMPLink to PubMed article][IPILink to PubMed article]
    mRNA cleavage [IMPLink to PubMed article][IPILink to PubMed article]
    snoRNA 3'-end processing [IMPLink to PubMed article]
    Molecular Function: RNA binding [ICLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDPRRRTGR HFLTPENLSS TLQITNLPPE WNQDIITSVV AGSGPVIDIK AKNDPRTGKL  60
   61 TGVLFDYLTS KDCKRAWEIL NRIENFPVKI EQIIPPNYKD HLRETANKNS QKQVLQLNRD 120
  121 SYPFEAGLEL PFEMVTEVPI PRRPPPPQAA NNTNSVSNNT NIQFPDILSK ASKHLPSFQD 180
  181 GSIIAPDKIS QNLSKIPPLQ LIEIISNLKI LSNQENIQKS QLESFLDTNS DITISVTQAL 240
  241 LEMGFIDYSV VTKVLKSQVG EAPSLLSSNN TSNSNTPVSV IRNNTPLHVP SNEVSNNPNN 300
  301 MPLNVAMPMP MSTPPFIPLP LQQQPFGFAP PGPFMPPAQG PSMGQPVLAN QLGQVQQQNI 360
  361 SSTEGPSNAN KANDSGTINM AKLQLLPENQ QDMIKQVLTL TPAQIQSLPS DQQLMVENFR 420
  421 KEYII

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 RNA14 SSU72 SWD2 SYC1 YSH1 YTH1
    View Details Krogan NJ, et al. (2006) AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
    View Details Gavin AC, et al. (2002) ACT1 ADE4 AIM31 BFR2 BMS1 BUD21 CBF5 CFT1 CFT2 CKA1 CLP1 DBP8 DIP2 ECM16 ECM29 EMG1 ENO2 ENP1 ENP2 ERO1 ESF1 ESF2 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA1 HTA2 IMP3 IMP4 KRE33 KRR1 MPE1 MPP10 MVD1 NAN1 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PCF11 PFK1 PFS2 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 REF2 RML2 RNA14 RNA15 ROK1 RPP2B RRP9 RSA3 RTG2 SCL1 SEC13 SEC21 SEC31 SOF1 SRO9 SSA3 SSU72 SYC1 TAF6 TIF1, TIF2 TIF4632 TYE7 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
    View Details Qiu et al. (2008) CFT1 CFT2 CLP1 FIP1 HRP1 MPE1 PFS2 PTA1 PTI1 REF2 RNA14 RNA15 SWD2 SYC1 YTH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PTI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] ORFEUS 10.6 Sex-lethal protein
    2 View Details [104..260] ORFEUS 10.6 Sex-lethal protein
    3 View Details [261..425] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • RNA binding
    		•  4.74219150342477 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.23531598582972 bayes_pls_golite062009
  • binding
    		•  4.00350364031155 bayes_pls_golite062009
  • mRNA binding
    		•  3.63162433534903 bayes_pls_golite062009
    		• 3.21905850396301 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.2045206027152 bayes_pls_golite062009
  • DNA binding
    		•  1.74537942253096 bayes_pls_golite062009
  • protein binding
    		•  1.26544376923141 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.19033433766236 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.08300488237934 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.960399311787502 bayes_pls_golite062009
  • ligase activity
    		•  0.912895392833756 bayes_pls_golite062009
  • transcription factor activity
    		•  0.894914712180715 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.633093884585572 bayes_pls_golite062009
  • snRNA binding
    		•  0.448300421677168 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.238420044364247 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.229644510503376 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle