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Protein Overview: ECM21

General Information:
Name(s) found: ECM21 / YBL101C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1117 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFITSRPVA KNSSHSLSET DLNQSKGQPF QPSPTKKLGS MQQRRRSSTI RHALSSLLGG  60
   61 ANVHSPAVLN NTTKGGNNNG NIRSSNTDAQ LLGKKQNKQP PPNARRHSTT AIQGSISDSA 120
  121 TTTPRSSTSD TNRRTSGRLS VDQEPRISGG RYSQIEEDST VLDFDDDHNS SAVVSSDLSS 180
  181 TSLTRLANSK KFNEQFLIEY LTARGLLGPK TVLSNEYLKI SISTSGESVF LPTISSNDDE 240
  241 YLSRLNGLND GTDDAEADFF MDGIDQQEGN TPSLATTAAA TESGGSINEN RDTLLRENNS 300
  301 GDHPGSGSEL NTRSVEIDSS MVSYSIAVIV SVKKPTRFTD MQLELCSRVK VFWNTGVPPT 360
  361 KTFNEEFYNA ASMKWNLNDE NFDLFVPLSI SPDDQMIENN SNDRQMRLFK NIPTEERLYL 420
  421 DKTKTKASLL NAIDVNKTHL YQPGDYVFLV PVVFSNHIPE TIYLPSARVS YRLRLATKAI 480
  481 NRKGFYRQDS NSPQPIVSPD SSSSLSSTTS SLKLTETESA QAHRRISNTL FSKVKNHLHM 540
  541 SSHQLKNEES GEEDIFAEYP IKVIRTPPPV AVSTANKPIY INRVWTDSLS YEISFAQKYV 600
  601 SLNSEVPIKI KLAPICKNVC VKRIHVSITE RVTFVSKGYE YEYDQTDPVA KDPYNPYYLD 660
  661 FASKRRKERS VSLFEIRTKE KGTRALREEI VENSFNDNLL SYSPFDDDSD SKGNPKERLG 720
  721 ITEPIIIETK LKFPKYEDLD KRTAKIIPPY GIDAYTSIPN PEHAVANGPS HRRPSVIGFL 780
  781 SGHKGSKSHE ENEKPVYDPK FHQTIIKSNS GLPVKTHTRL NTPKRGLYLD SLHFSNVYCR 840
  841 HKLEIMLRIS KPDPECPSKL RHYEVLIDTP IFLVSEQCNS GNMELPTYDM ATMEGKGNQV 900
  901 PLSMNSDFFG NTCPPPPTFE EAISVPASPI VSPMGSPNIM ASYDPDLLSI QQLNLSRTTS 960
  961 VSGPSGYSDD AGVPNVNRNS ISNANAMNGS ISNSAFVSGN SGQGVARARA TSVNDRSRFN1020
 1021 NLDKLLSTPS PVNRSHNSSP TNGLSQANGT VRIPNATTEN SKDKQNEFFK KGYTLANVKD1080
 1081 DEEQEGIVSS SSADSLLSHG NEPPRYDEIV PLMSDEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECM21 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..507] deduced N/A No confident structure predictions are available.
    2 View Details [508..703] MSA 8.01098 View MSA. No confident structure predictions are available.
    3 View Details [704..1117] deduced N/A No confident structure predictions are available.
    4 View Details [387..878] FFAS03 1.29 Arrestin
    5 View Details [879..1117] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.80286284844302 bayes_pls_golite062009
  • protein binding
    		•  1.608080422834 bayes_pls_golite062009
  • transporter activity
    		•  1.10239137184953 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.949536954960448 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.781060752903079 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.660409340901077 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.56446678342098 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.486294295028555 bayes_pls_golite062009
  • channel activity
    		•  0.465630241372545 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.465630241372545 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.455589501590218 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.44519612509266 bayes_pls_golite062009
  • potassium channel activity
    		•  0.423464159542763 bayes_pls_golite062009
  • cation channel activity
    		•  0.406614358442595 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.402494949667906 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.39571309893169 bayes_pls_golite062009
  • ion channel activity
    		•  0.395022246697853 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.387394052239826 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.326855275194847 bayes_pls_golite062009
  • gated channel activity
    		•  0.266124158878986 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle