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Protein Overview: PTA1

General Information:
Name(s) found: PTA1 / YAL043C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 785 amino acids

    Gene Ontology:
    Cellular Component: mRNA cleavage and polyadenylation specificity factor complex [IPILink to PubMed article]
    mRNA cleavage factor complex [IPILink to PubMed article]
    Biological Process: termination of RNA polymerase II transcription, poly(A)-coupled [IPILink to PubMed article]
    tRNA processing [IMPLink to PubMed article]
    termination of RNA polymerase II transcription, poly(A)-independent [IPILink to PubMed article]
    mRNA polyadenylation [IMPLink to PubMed articleLink to PubMed article]
    mRNA cleavage [IMPLink to PubMed article]
    Molecular Function: RNA binding [ICLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAEMEQLL QAKTLAMHNN PTEMLPKVLE TTASMYHNGN LSKLKLPLAK FFTQLVLDVV  60
   61 SMDSPIANTE RPFIAAQYLP LLLAMAQSTA DVLVYKNIVL IMCASYPLVL DLVAKTSNQE 120
  121 MFDQLCMLKK FVLSHWRTAY PLRATVDDET DVEQWLAQID QNIGVKLATI KFISEVVLSQ 180
  181 TKSPSGNEIN SSTIPDNHPV LNKPALESEA KRLLDMLLNY LIEEQYMVSS VFIGIINSLS 240
  241 FVIKRRPQTT IRILSGLLRF NVDAKFPLEG KSDLNYKLSK RFVERAYKNF VQFGLKNQII 300
  301 TKSLSSGSGS SIYSKLTKIS QTLHVIGEET KSKGILNFDP SKGNSKKTLS RQDKLKYISL 360
  361 WKRQLSALLS TLGVSTKTPT PVSAPATGSS TENMLDQLKI LQKYTLNKAS HQGNTFFNNS 420
  421 PKPISNTYSS VYSLMNSSNS NQDVTQLPND ILIKLSTEAI LQMDSTKLIT GLSIVASRYT 480
  481 DLMNTYINSV PSSSSSKRKS DDDDDGNDNE EVGNDGPTAN SKKIKMETEP LAEEPEEPED 540
  541 DDRMQKMLQE EESAQEISGD ANKSTSAIKE IAPPFEPDSL TQDEKLKYLS KLTKKLFELS 600
  601 GRQDTTRAKS SSSSSILLDD DDSSSWLHVL IRLVTRGIEA QEASDLIREE LLGFFIQDFE 660
  661 QRVSLIIEWL NEEWFFQTSL HQDPSNYKKW SLRVLESLGP FLENKHRRFF IRLMSELPSL 720
  721 QSDHLEALKP ICLDPARSSL GFQTLKFLIM FRPPVQDTVR DLLHQLKQED EGLHKQCDSL 780
  781 LDRLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 RNA14 SSU72 SWD2 SYC1 YSH1 YTH1
    View Details (MIPS) Mewes HW, et al. (2004) CFT1 CFT2 FIP1 PTA1 YSH1
    View Details Krogan NJ, et al. (2006) AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
    View Details Gavin AC, et al. (2006) CFT1 CFT2 FIP1 MPE1 PAP1 PFS2 PTA1 YSH1 YTH1
    View Details Gavin AC, et al. (2002) ACT1 ADE4 AIM31 BFR2 BMS1 BUD21 CBF5 CFT1 CFT2 CKA1 CLP1 DBP8 DIP2 ECM16 ECM29 EMG1 ENO2 ENP1 ENP2 ERO1 ESF1 ESF2 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA1 HTA2 IMP3 IMP4 KRE33 KRR1 MPE1 MPP10 MVD1 NAN1 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PCF11 PFK1 PFS2 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 REF2 RML2 RNA14 RNA15 ROK1 RPP2B RRP9 RSA3 RTG2 SCL1 SEC13 SEC21 SEC31 SOF1 SRO9 SSA3 SSU72 SYC1 TAF6 TIF1, TIF2 TIF4632 TYE7 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
    View Details Qiu et al. (2008) CFT1 CLP1 FIP1 HRP1 MPE1 PFS2 PTA1 PTI1 SSU72 SYC1 YSH1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PTA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..261] MSA 4.01094 View MSA. No confident structure predictions are available.
    2 View Details [262..505] deduced N/A No confident structure predictions are available.
    3 View Details [506..785] MSA 1.006933 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle