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Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: mRNA cleavage and polyadenylation specificity factor complex
Acc: GO:0005847
Aspect: Cellular Component
Desc: A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
Synonyms:
  • cleavage and polyadenylylation specificity factor activity
  • CPF complex
  • CPSF complex
  • CFII complex
Proteins in PDR annotated with:
   This term: 64 [Search]
   Term or descendants: 64 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle