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Protein Overview: ECM16

General Information:
Name(s) found: ECM16 / YMR128W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1267 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IPILink to PubMed article]
    ribosome biogenesis [IDALink to PubMed article][RCALink to PubMed article][TASLink to PubMed article]
    Molecular Function: RNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTYRKRFNE KARSGHMAKL KELKRIRNKQ FTRQDENDER VENPDSAPAE SSTTEPNANA  60
   61 EILEPLTEEE KKMKKRKLQE LFTPKESKVS RLKKKRLDKF IEHQLKREER KTIIGKLQDY 120
  121 KIDTSLLTSS KRLGEGRQTK KEEFKEALSL ERQGRGNEQT NEILYEEYEP KVWDEYGEGG 180
  181 SSEDDDGEDD FEASFGSMPK PTDNEEKKSS GFIDHRPAKF GGSGLSFGFS NIKVINKESK 240
  241 TPKKKYNWRQ RVEMEELKKH GKEDEMDFDT TSEDDDEEED QEEEDKMHPS ENPLEEVESA 300
  301 DSETGSEKFD QNDVANEFKD WANQEIKKLE GRDQELVTPT LNIDYKPIIR KEDLDDGLQE 360
  361 AYVPINENST RKAFYVEVSR SDEIQKARIQ LPVFGEEHKI MEAIHHNDVV IICGETGSGK 420
  421 TTQVPQFLYE AGFGAEDSPD YPGMVGITQP RRVAAVSMAE RVANELGDHG HKVGYQIRFD 480
  481 STAKEDTKVK FMTDGVLLRE MMHDFKLTKY SSIIIDEAHE RNINTDILIG MLSRCVRLRA 540
  541 KLHKENPIEH KKLKLIIMSA TLRVSDFSEN KTLFPIAPPV LQVDARQFPV SIHFNRRTAF 600
  601 NYTDEAFRKT CKIHQKLPPG AILVFLTGQQ EITHMVKRLR KEFPFKKNSK YNKDLETPVS 660
  661 KMGINSKTTD LEAEDIDFSV QVIDQDKFKS AIRYEEDEGN SGNGEDEEDE EEEGFEEVLT 720
  721 EGQTANDPLY VLPLYSLLPT KEQMRVFQKP PQGSRLCIVA TNVAETSLTI PGVRYVVDSG 780
  781 RSKERKYNES NGVQSFEVGW VSKASANQRS GRAGRTGPGH CYRLYSSAVF EHDFEQFSKP 840
  841 EILRMPVESI VLQMKSMAIH NIINFPFPTP PDRVALSKAI QLLQYLGALD NKEMITEDGK 900
  901 KMSLFPLSPR FSKMLLVSDE KACLPYIVAI VSALSVGDPF INEFELGINE ISRKPNPDEN 960
  961 LDDKIREHDE STPGMDPELK KELRSKFYKS RSQFSKLDKF SDVFRLLSVV SAMDYVPKEQ1020
 1021 KEIFMKKNFL RGKLMEEIVK LRKQLMYIIK SNTSKENIAV VIRNEDLKSD IPSVIQIKLL1080
 1081 KQMICAGFVD HVAVRADVLF PDDAKITNRT SIINIPYIPV LATRTPNIED CFVYIHPTSI1140
 1141 LNNLGEMPPK YMLYYSLHLG GNNKTRMNTL CDIASTPLAN IARKGLLLTY SKPLTGQGLK1200
 1201 TVNLSPTERY CYVVPRFGST VDNDLKIGWD LNPIAVHQKK QKGQWTVIKF ITRKGFQTIT1260
 1261 GEEKEKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 BUD23 DIP2 DIS3 ECM16 EMG1 ENP1 ENP2 FUN12 IMP3 IMP4 KRE33 KRR1 MAK5 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 PRP43 PWP2 RCL1 RPL5 RPS11A, RPS11B RPS13 RPS4B, RPS4A RPS7A RPS8B, RPS8A RRP12 RRP9 SOF1 TSR1 UTP10 UTP13 UTP15 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8
    View Details Krogan NJ, et al. (2006) ASF2 BUD23 ECM16 REB1
    View Details Gavin AC, et al. (2002) ABF2 ADE4 ADH1 ASC1 BEM2 BFR2 BMS1 BRX1 BUD21 CBF5 CCM1 CFT2 CKA1 CKA2 CKB1 CKB2 CMD1 CMS1 CSL4 CTI6 CTR9 DBP8 DEP1 DIA4 DIM1 DIP2 DIS3 DOT6 EAF3 ECM16 ECM29 EHD3 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 FYV4 GCN1 GEP3 GLC7 HAS1 HCA4 HHF1, HHF2 HRR25 HSC82 HSL1 HTA2 IMP3 IMP4 IOC3 ISW1 KRE33 KRR1 LCP5 LRP1 LTV1 MAM33 MED4 MLC1 MPP10 MRD1 MRP1 MRP10 MRP13 MRP17 MRP21 MRP4 MRP51 MRPS16 MRPS17 MRPS18 MRPS28 MRPS5 MRPS8 MRPS9 MTR3 MVD1 MYO2 NAM9 NAN1 NHP10 NMD5 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 NRD1 PAP1 PAP2 PET123 PFS2 PHO23 PNO1 PRE6 PRE9 PRP43 PSD2 PTA1 PTI1 PUS7 PWP2 RCL1 RCO1 REF2 RIO2 RIX1 RML2 RNA14 ROK1 RPD3 RPP2B RRP12 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 RRP7 RRP9 RSC8 RSM10 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 RTG2 RXT2 RXT3 SAM1 SAP30 SCL1 SDS3 SEC21 SHE4 SIN3 SKI2 SKI3 SKI6 SKI7 SLX9 SNF2 SNF5 SOF1 SRO9 SRP1 STO1 SWI3 TIF1, TIF2 TIF4631 TOP1 TSR1 TUP1 UBP10 UME1 UME6 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YGR054W YIR035C YOR059C YSH1
    View Details Qiu et al. (2008) DBP3 DBP6 DHR2 DRS1 ECM16 GAR1 MAK5 NSR1 NUG1 UTP4 UTP6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECM16 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..291] PSI-BLAST 47.30103 Heavy meromyosin subfragment
    2 View Details [292..408] deduced N/A No confident structure predictions are available.
    3 View Details [409..584] PSI-BLAST 4.221849 Putative DEAD box RNA helicase
    4 View Details [585..695] PSI-BLAST 4.221849 Putative DEAD box RNA helicase
    5 View Details [696..853] ORFEUS 12.3 Initiation factor 4a
    6 View Details [854..1267] MSA 4.132947 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle